scholarly journals Protective effects of Pleurotus ostreatus in ameliorating carbon tetrachloride (ccl4) induced liver injury in Wistar rats

2019 ◽  
Vol 13 (5) ◽  
pp. 104-111
Author(s):  
A. E. Ubhenin ◽  
F. A. Adamude ◽  
C. C. Nweze ◽  
E. J. Dingwoke
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Pleurotus Ostreatus ◽  
Wistar Rats ◽  
Protective Effects

scholarly journals Lemon Balm and Dandelion Leaf Extracts Synergistically Protect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

2021 ◽  
Vol 11 (1) ◽  
pp. 390
Author(s):  
Beom-Rak Choi ◽  
Il-Je Cho ◽  
Su-Jin Jung ◽  
Jae-Kwang Kim ◽  
Dae-Geon Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Antioxidant Activities ◽  
Body Weight Gain ◽  
Histopathological Analysis ◽  
Related Factor ◽  
Mrna Levels ◽  
Protective Effects ◽  
Lemon Balm

Lemon balm and dandelion are commonly used medicinal herbs exhibiting numerous pharmacological activities that are beneficial for human health. In this study, we explored the protective effects of a 2:1 (w/w) mixture of lemon balm and dandelion extracts (MLD) on carbon tetrachloride (CCl4)-induced acute liver injury in mice. CCl4 (0.5 mL/kg; i.p.) injection inhibited body weight gain and increased relative liver weight. Pre-administration of MLD (50–200 mg/kg) for 7 days prevented these CCl4-mediated changes. In addition, histopathological analysis revealed that MLD synergistically alleviated CCl4-mediated hepatocyte degeneration and infiltration of inflammatory cells. MLD decreased serum aspartate aminotransferase and alanine transferase activities and reduced the number of liver cells that stained positive for cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase, suggesting that MLD protects against CCl4-induced hepatic damage via the inhibition of apoptosis. Moreover, MLD attenuated CCl4-mediated lipid peroxidation and protein nitrosylation by restoring impaired hepatic nuclear factor erythroid 2-related factor 2 mRNA levels and its dependent antioxidant activities. Furthermore, MLD synergistically decreased mRNA and protein levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the liver. Together, these results suggest that MLD has potential for preventing acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation.

Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice

2017 ◽  
Vol 8 (9) ◽  
pp. 3276-3287 ◽  
Author(s):  
Wei-Lun Hung ◽  
Guliang Yang ◽  
Yu-Chuan Wang ◽  
Yi-Shiou Chiou ◽  
Yen-Chen Tung ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effects

TSA markedly reduced the CCl4-induced liver injury in mice.

Protective effects of BML-111, a lipoxin A4receptor agonist, on carbon tetrachloride-induced liver injury in mice

2007 ◽  
Vol 37 (11) ◽  
pp. 948-956 ◽  
Author(s):  
Li Zhang ◽  
Jingyuan Wan ◽  
Hongzhong Li ◽  
Ping Wu ◽  
Shengwei Jin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effects

Protective effects of salecan against carbon tetrachloride-induced acute liver injury in mice

2011 ◽  
Vol 32 (10) ◽  
pp. 796-803 ◽  
Author(s):  
Peng Chen ◽  
Zhongqiu Wang ◽  
Liyan Zeng ◽  
Shiming Wang ◽  
Wei Dong ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Protective Effects

scholarly journals Bioactive properties: enhancement of hepatoprotective, antioxidant and DNA damage protective effects of golden grey mullet protein hydrolysates against paracetamol toxicity

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 23230-23240
Author(s):  
Intidhar Bkhairia ◽  
Sabah Dhibi ◽  
Rim Nasri ◽  
Abdelfettah Elfeki ◽  
Najla Hfaiyedh ◽  
...  
Keyword(s):  
Dna Damage ◽  
Liver Injury ◽  
Wistar Rats ◽  
Protein Hydrolysates ◽  
Protective Effects ◽  
Grey Mullet ◽  
Liza Aurata ◽  
Bioactive Properties ◽  
Paracetamol Toxicity ◽  
Dna Damage Protective

This study was undertaken to examine the hepatoprotective, antioxidant, and DNA damage protective effects of protein hydrolysates fromLiza aurata, against paracetamol overdose induced liver injury in Wistar rats.

Effects and Mechanisms of Acremoniumterricola milleretal mycelium on Liver Fibrosis Induced by Carbon Tetrachloride in Rats

2011 ◽  
Vol 39 (03) ◽  
pp. 537-550 ◽  
Author(s):  
Xiao-Peng Tian ◽  
Yan-Yan Yin ◽  
Xia Li
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Liver Injury ◽  
Chinese Herb ◽  
Immunoblot Analysis ◽  
Hepatoprotective Activity ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Procollagen Type ◽  
Tgf Β1

Acremoniumterricola milleretal mycelium (AMM) is one of the most precious traditional Chinese medicines. It has numerous protective effects on organs, and has been used in Chinese herb prescription to treat refractory diseases. Our preliminary studies demonstrated that AMM had hepatoprotective activity in acute liver injury. We further investigated the effects of AMM on liver fibrosis in rats induced by carbon tetrachloride ( CCl 4) and explore its possible mechanisms. The animal model was established by injection with 50% CCl 4 subcutaneously in male Sprague-Dawley rats twice a week for eight weeks. Meanwhile, AMM (175, 350 and 700 mg/kg) was administered intragastrically per day until sacrifice. We found that treatment with AMM (175, 350 and 700 mg/kg) decreased CCl 4-induced elevation of serum transaminase activities, hyaluronic acid, laminin and procollagen type III levels, and contents of hydroxyproline in liver tissues. It also restored the decreased SOD and GSH-Px activities and inhibited the formation of lipid peroxidative products during CCl 4 treatment. Moreover, AMM (350 and 700 mg/kg) decreased the elevation of TGF-β1 by 19.6% and 34.3%, respectively. In the pathological study, liver injury and the formation of liver fibrosis in rates treated by AMM were improved significantly. Immunoblot analysis showed that AMM (175, 350 and 700 mg/kg) inhibited Smad 2/3 phosphorylation, and elevated inhibitor Smad 7 expression. These results suggested that AMM could protect liver damage and inhibit the progression of hepatic fibrosis induced by CCl 4, and its mechanisms might be associated with its ability to scavenge free radicals, decrease the level of TGF-β1 and block TGF-β/Smad signaling pathway.

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