scholarly journals A Size Expansion Analysis using a Toy Model based on the Equivalence between Bondi K–Factor and Exponential Function

2015 ◽  
Vol 60 (1) ◽  
pp. 93-96
Author(s):  
Masataka Shimojo
Keyword(s):  
Exponential Function ◽  
Model Based ◽  
K Factor

scholarly journals Model based safety ranking of opioid drugs using Adversity index

2017 ◽  
Author(s):  
Krishna Asvalayana ◽  
Samadhan Ghubade ◽  
Sharayu Paranjpe ◽  
Anil Gore
Keyword(s):  
Rate Constant ◽  
Exponential Function ◽  
Exponential Model ◽  
Model Based ◽  
Link Type ◽  
Key Points ◽  
Opioid Drugs ◽  
Suitable Index

AbstractAnnual ADR report counts of opioid drugs are examined to develop a candidate index of overall safety of a drug. Actual counts for various drugs have been sourced from www.vigiaccess.org. A feature found to be common to all drugs considered is that an exponential function adequately describes the pattern of cumulative counts. In the exponential model, the parameter in the exponent (rate constant) is robust and remains the same whether counts are corrected for exposure or not. We propose use of this rate constant as ‘adversity index’ of a drug. Drugs in use can be ranked by value of adversity index, lower value suggesting safer drug.Key pointsCumulative total of annual ADR report counts of opioid drugs follows an exponential pattern. Rate constant in the model is independent of volume of use of the drug. Hence it is a suitable index of overall safety.

Representation, abstraction, and simple-minded sophisticates

2020 ◽  
Vol 43 ◽  
Author(s):  
Peter Dayan
Keyword(s):  
Decision Theory ◽  
Predictive Coding ◽  
Bayesian Decision Theory ◽  
Bayesian Decision ◽  
Model Based ◽  
Model Free

Abstract Bayesian decision theory provides a simple formal elucidation of some of the ways that representation and representational abstraction are involved with, and exploit, both prediction and its rather distant cousin, predictive coding. Both model-free and model-based methods are involved.

Quantitative Model-Based Image Analysis of NuMa Distribution Links Nuclear Organization with Cell Phenotype

2001 ◽  
Vol 7 (S2) ◽  
pp. 578-579
Author(s):  
David W. Knowles ◽  
Sophie A. Lelièvre ◽  
Carlos Ortiz de Solόrzano ◽  
Stephen J. Lockett ◽  
Mina J. Bissell ◽  
...  
Keyword(s):  
Image Analysis ◽  
Mammary Epithelial Cells ◽  
Nuclear Organization ◽  
Critical Role ◽  
Quantitative Model ◽  
Mammary Epithelial ◽  
Cell Phenotype ◽  
Proliferating Cells ◽  
Mitotic Apparatus ◽  
Model Based

The extracellular matrix (ECM) plays a critical role in directing cell behaviour and morphogenesis by regulating gene expression and nuclear organization. Using non-malignant (S1) human mammary epithelial cells (HMECs), it was previously shown that ECM-induced morphogenesis is accompanied by the redistribution of nuclear mitotic apparatus (NuMA) protein from a diffuse pattern in proliferating cells, to a multi-focal pattern as HMECs growth arrested and completed morphogenesis . A process taking 10 to 14 days.To further investigate the link between NuMA distribution and the growth stage of HMECs, we have investigated the distribution of NuMA in non-malignant S1 cells and their malignant, T4, counter-part using a novel model-based image analysis technique. This technique, based on a multi-scale Gaussian blur analysis (Figure 1), quantifies the size of punctate features in an image. Cells were cultured in the presence and absence of a reconstituted basement membrane (rBM) and imaged in 3D using confocal microscopy, for fluorescently labeled monoclonal antibodies to NuMA (fαNuMA) and fluorescently labeled total DNA.

Model-Based Clustering and Classification for Data Science

2019 ◽  
Author(s):  
Charles Bouveyron ◽  
Gilles Celeux ◽  
T. Brendan Murphy ◽  
Adrian E. Raftery
Keyword(s):  
Data Science ◽  
Model Based Clustering ◽  
Model Based ◽  
Clustering And Classification

Model-Based Software Testing and Analysis with C#

2007 ◽  
Author(s):  
Jonathan Jacky ◽  
Margus Veanes ◽  
Colin Campbell ◽  
Wolfram Schulte
Keyword(s):  
Software Testing ◽  
Model Based
Sign in / Sign up

Export Citation Format

Share Document