scholarly journals Anti- Asprosin: A Potential Protective Role Against the Progression of Diabetic Nephropathy in Type 2 Diabetic Rats

2019 ◽  
pp. 183-199 ◽  
Author(s):  
HANY A. EL KATTAWY ◽  
WESAM M.R. ASHOUR
Keyword(s):  
Diabetic Nephropathy ◽  
Protective Role ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Anti-oxidative effect of theβ-blocker carvedilol on diabetic nephropathy in non-obese type 2 diabetic rats

2015 ◽  
Vol 42 (9) ◽  
pp. 972-978 ◽  
Author(s):  
Yuriko Yonekura ◽  
Hideki Fujii ◽  
Kentaro Nakai ◽  
Keiji Kono ◽  
Shunsuke Goto ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Type 2 Diabetic ◽  
Oxidative Effect

scholarly journals Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats

2008 ◽  
Vol 23 (9) ◽  
pp. 2750-2760 ◽  
Author(s):  
G. J. Ko ◽  
Y. S. Kang ◽  
S. Y. Han ◽  
M. H. Lee ◽  
H. K. Song ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Inflammatory Mechanism ◽  
Anti Inflammatory ◽  
Type 2 Diabetic

Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats

2017 ◽  
Vol 94 ◽  
pp. 726-741 ◽  
Author(s):  
Ritu Khanra ◽  
Niloy Bhattacharjee ◽  
Tarun K. Dua ◽  
Ashis Nandy ◽  
Achintya Saha ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Pentacyclic Triterpenoid ◽  
Type 2 Diabetic

scholarly journals Nephroprotective effects of diacylglycerol on diabetic nephropathy in type 2 diabetic rats

2017 ◽  
Author(s):  
Jianpeng Li ◽  
Yongheng Yan ◽  
Duo Li ◽  
Xia Li ◽  
Xinying Lin ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Zhenqing recipe alleviates diabetic nephropathy in experimental type 2 diabetic rats through suppression of SREBP-1c

2012 ◽  
Vol 142 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Xiuying Wen ◽  
Yali Zeng ◽  
Lifang Liu ◽  
Hui Zhang ◽  
Wenguang Xu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Experimental Type ◽  
Type 2 Diabetic

scholarly journals Protective effects of alkali‐extracted rice protein on diabetic nephropathy in obese type 2 diabetic rats

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Masatoshi Kubota ◽  
Reiko Watanabe ◽  
Miki Yamaguchi ◽  
Michihiro Hosojima ◽  
Akihiko Saito ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Rice Protein ◽  
Type 2 Diabetic

scholarly journals Antidiabetic and Renoprotective Effects ofCladophora glomerataKützing Extract in Experimental Type 2 Diabetic Rats: A Potential Nutraceutical Product for Diabetic Nephropathy

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Chutima Srimaroeng ◽  
Atcharaporn Ontawong ◽  
Naruwan Saowakon ◽  
Pornpun Vivithanaporn ◽  
Anchalee Pongchaidecha ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Antioxidant Activities ◽  
Organic Anion ◽  
Diabetic Rats ◽  
Cladophora Glomerata ◽  
Anion Transporters ◽  
Renal Morphology ◽  
Experimental Type ◽  
Type 2 Diabetic

Cladophora glomerataextract (CGE) has been shown to exhibit antigastric ulcer, anti-inflammatory, analgesic, hypotensive, and antioxidant activities. The present study investigated antidiabetic and renoprotective effects of CGE in type 2 diabetes mellitus (T2DM) rats. The rats were induced by high-fat diet and streptozotocin and supplemented daily with 1 g/kg BW of CGE for 12 weeks. The renal transport function was assessed by the uptake ofpara-aminohippurate mediated organic anion transporters 1 (Oat1) and 3 (Oat3), using renal cortical slices. These two transporters were known to be upregulated by insulin and PKCζwhile they were downregulated by PKCαactivation. Compared to T2DM, CGE supplemented rats had significantly improved hyperglycaemia, hypertriglyceridemia, insulin resistance, and renal morphology. The baseline uptake ofpara-aminohippurate was not different among experimental groups and was correlated with Oat1 and 3 mRNA expressions. Nevertheless, while insulin-stimulated Oat1 and 3 functions in renal slices were blunted in T2DM rats, they were improved by CGE supplementation. The mechanism of CGE-restored insulin-stimulated Oat1 and 3 functions was clearly shown to be associated with upregulated PKCζand downregulated PKCαexpressions and activations. These findings indicate that CGE has antidiabetic effect and suggest it may prevent diabetic nephropathy through PKCs in a T2DM rat model.

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