Zhenqing recipe alleviates diabetic nephropathy in experimental type 2 diabetic rats through suppression of SREBP-1c

2012 ◽  
Vol 142 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Xiuying Wen ◽  
Yali Zeng ◽  
Lifang Liu ◽  
Hui Zhang ◽  
Wenguang Xu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Rats ◽  
Experimental Type ◽  
Type 2 Diabetic

scholarly journals Antidiabetic and Renoprotective Effects ofCladophora glomerataKützing Extract in Experimental Type 2 Diabetic Rats: A Potential Nutraceutical Product for Diabetic Nephropathy

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Chutima Srimaroeng ◽  
Atcharaporn Ontawong ◽  
Naruwan Saowakon ◽  
Pornpun Vivithanaporn ◽  
Anchalee Pongchaidecha ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Antioxidant Activities ◽  
Organic Anion ◽  
Diabetic Rats ◽  
Cladophora Glomerata ◽  
Anion Transporters ◽  
Renal Morphology ◽  
Experimental Type ◽  
Type 2 Diabetic

Cladophora glomerataextract (CGE) has been shown to exhibit antigastric ulcer, anti-inflammatory, analgesic, hypotensive, and antioxidant activities. The present study investigated antidiabetic and renoprotective effects of CGE in type 2 diabetes mellitus (T2DM) rats. The rats were induced by high-fat diet and streptozotocin and supplemented daily with 1 g/kg BW of CGE for 12 weeks. The renal transport function was assessed by the uptake ofpara-aminohippurate mediated organic anion transporters 1 (Oat1) and 3 (Oat3), using renal cortical slices. These two transporters were known to be upregulated by insulin and PKCζwhile they were downregulated by PKCαactivation. Compared to T2DM, CGE supplemented rats had significantly improved hyperglycaemia, hypertriglyceridemia, insulin resistance, and renal morphology. The baseline uptake ofpara-aminohippurate was not different among experimental groups and was correlated with Oat1 and 3 mRNA expressions. Nevertheless, while insulin-stimulated Oat1 and 3 functions in renal slices were blunted in T2DM rats, they were improved by CGE supplementation. The mechanism of CGE-restored insulin-stimulated Oat1 and 3 functions was clearly shown to be associated with upregulated PKCζand downregulated PKCαexpressions and activations. These findings indicate that CGE has antidiabetic effect and suggest it may prevent diabetic nephropathy through PKCs in a T2DM rat model.

Antihyperglycemic and Antihyperlipidemic Effects of Ferula duranii in Experimental Type 2 Diabetic Rats

2015 ◽  
Vol 11 (6) ◽  
pp. 532-541 ◽  
Author(s):  
Hasan S. Yusufoglu ◽  
Gamal A. Soliman ◽  
Rehab F. Abdel-Rahm ◽  
Maged Saad Abdel-Kade ◽  
Majid A. Ganaie ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Experimental Type ◽  
Type 2 Diabetic

Antidiabetic and antioxidant effect of Swietenia macrophylla seeds in experimental type 2 diabetic rats

2013 ◽  
Vol 33 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Moumita Dutta ◽  
Utpal Kumar Biswas ◽  
Runu Chakraborty ◽  
Piyasa Banerjee ◽  
Debasish Maji ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antioxidant Effect ◽  
Swietenia Macrophylla ◽  
Experimental Type ◽  
Type 2 Diabetic

Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats

2012 ◽  
Vol 51 (5) ◽  
pp. 749-755 ◽  
Author(s):  
Pei-Bo Li ◽  
Wan-Ling Lin ◽  
Yong-Gang Wang ◽  
Wei Peng ◽  
Xue-Ying Cai ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Experimental Type ◽  
Type 2 Diabetic
Sign in / Sign up

Export Citation Format

Share Document