scholarly journals Morgellons disease etiology and therapeutic approach: a systematic review

2021 ◽  
Vol 27 (8) ◽  
Author(s):  
Katherine G Beuerlein ◽  
Esther A Balogh ◽  
Steven R Feldman
Keyword(s):  
Systematic Review ◽  
Therapeutic Approach ◽  
Disease Etiology ◽  
Morgellons Disease

scholarly journals Systematic review of the pharmacological agents that have been tested against spreading depolarizations

2018 ◽  
Vol 38 (7) ◽  
pp. 1149-1179 ◽  
Author(s):  
Anna Klass ◽  
Renan Sánchez-Porras ◽  
Edgar Santos
Keyword(s):  
Systematic Review ◽  
Clinical Outcome ◽  
Therapeutic Approach ◽  
Brain Injuries ◽  
Neuronal Damage ◽  
Major Objective ◽  
Pharmacological Agents ◽  
Pharmacological Modulation ◽  
Spreading Depolarization ◽  
Other Substances

Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article was to produce a systematic review of all the drugs that have been tested against SD. Of the substances that have been examined, most have been shown to modulate certain SD characteristics. Only a few have succeeded in significantly inhibiting SD. We present a variety of strategies that have been proposed to overcome the notorious harmfulness and pharmacoresistance of SD. Information on clinically used anesthetic, sedative, hypnotic agents, anti-migraine drugs, anticonvulsants and various other substances have been compiled and reviewed with respect to the efficacy against SD, in order to answer the question of whether a drug at safe doses could be of therapeutic use against SD in humans.

Diagnostic and therapeutic approach to meniscal ossification: a systematic review

2020 ◽  
Author(s):  
Athanasios N. Ververidis ◽  
Anthimos Keskinis ◽  
Konstantinos Paraskevopoulos ◽  
Nikolaos Adrianos Ververidis ◽  
Stylianos Tottas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Therapeutic Approach

scholarly journals A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment

2013 ◽  
Vol 2013 ◽  
pp. 1-53 ◽  
Author(s):  
Katherine von Stackelberg
Keyword(s):  
Systematic Review ◽  
The United States ◽  
Epidemiologic Studies ◽  
Potential Interaction ◽  
Disease Etiology ◽  
Modes Of Action ◽  
Increased Risk ◽  
Toxicological Studies ◽  
Bioassay Data ◽  
2,4 Dichlorophenoxyacetic Acid

Chlorophenoxy compounds, particularly 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxy)acetic acid (MCPA), are amongst the most widely used herbicides in the United States for both agricultural and residential applications. Epidemiologic studies suggest that exposure to 2,4-D and MCPA may be associated with increased risk non-Hodgkins lymphoma (NHL), Hodgkin’s disease (HD), leukemia, and soft-tissue sarcoma (STS). Toxicological studies in rodents show no evidence of carcinogenicity, and regulatory agencies worldwide consider chlorophenoxies as not likely to be carcinogenic or unclassifiable as to carcinogenicity. This systematic review assembles the available data to evaluate epidemiologic, toxicological, pharmacokinetic, exposure, and biomonitoring studies with respect to key cellular events noted in disease etiology and how those relate to hypothesized modes of action for these constituents to determine the plausibility of an association between exposure to environmentally relevant concentrations of 2,4-D and MCPA and lymphohematopoietic cancers. The combined evidence does not support a genotoxic mode of action. Although plausible hypotheses for other carcinogenic modes of action exist, a comparison of biomonitoring data to oral equivalent doses calculated from bioassay data shows that environmental exposures are not sufficient to support a causal relationship. Genetic polymorphisms exist that are known to increase the risk of developing NHL. The potential interaction between these polymorphisms and exposures to chlorophenoxy compounds, particularly in occupational settings, is largely unknown.

Therapeutic approach to Lennox–Gastaut syndrome: a systematic review

2019 ◽  
Vol 119 (3) ◽  
pp. 315-324
Author(s):  
Serena Borrelli ◽  
Riem El Tahry
Keyword(s):  
Systematic Review ◽  
Therapeutic Approach

scholarly journals The Human Vulvar Microbiome: A Systematic Review

2021 ◽  
Vol 9 (12) ◽  
pp. 2568
Author(s):  
Lisa Pagan ◽  
Roos A. M. Ederveen ◽  
Bertine W. Huisman ◽  
Jan W. Schoones ◽  
Romy D. Zwittink ◽  
...  
Keyword(s):  
Systematic Review ◽  
Population Diversity ◽  
Original Research ◽  
Level Of Evidence ◽  
Disease Etiology ◽  
Microbiome Composition ◽  
Vulvar Disease ◽  
Culture Independent ◽  
Size Population ◽  
The Relationship

The link between cancer and the microbiome is a fast-moving field in research. There is little knowledge on the microbiome in ((pre)malignant) conditions of the vulvar skin. This systematic review aims to provide an overview of the literature regarding the microbiome composition of the healthy vulvar skin and in (pre)malignant vulvar disease. This study was performed according to the PRISMA guidelines. A comprehensive, electronic search strategy was used to identify original research articles (updated September 2021). The inclusion criteria were articles using culture-independent methods for microbiome profiling of the vulvar region. Ten articles were included. The bacterial composition of the vulva consists of several genera including Lactobacillus, Corynebacterium, Staphylococcus and Prevotella, suggesting that the vulvar microbiome composition shows similarities with the corresponding vaginal milieu. However, the vulvar microbiome generally displayed higher diversity with commensals of cutaneous and fecal origin. This is the first systematic review that investigates the relationship between microbiome and vulvar (pre)malignant disease. There are limited data and the level of evidence is low with limitations in study size, population diversity and methodology. Nevertheless, the vulvar microbiome represents a promising field for exploring potential links for disease etiology and targets for therapy.

scholarly journals The therapeutic approach of the May-Thurner Syndrome without Deep Venous Thrombosis: a systematic review

10.3823/2431 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Modesto Leite Rolim Neto ◽  
Thaís Abreu Luedy ◽  
Isadora Rodrigues Da Costa ◽  
João Vitor Pimentel ◽  
Francisco Henrique Peixoto Da Silva
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Endovascular Treatment ◽  
Therapeutic Approach ◽  
Radiofrequency Energy ◽  
Peripheral Vascular ◽  
Venous Flow ◽  
Compression Syndrome

May-Thurner Syndrome is a clinical condition which causes a variety of vascular symptoms, resulting from pelvic and lower extremity venous flow obstruction caused by the compression of the iliac vein by overlying iliac artery. Treatment paradigms have changed as experience with endovascular modalities has evolved, making traditional surgical treatment strategies essentially obsolete and a endovascular treatment with angioplasty and stenting along selective thrombolysis has become the standard for symptomatic the syndrome. The objective of this present study is to show the therapeutic approach in treatment when there’s no presence of Deep Venous Thrombosis (DVT) symptoms. To accomplish this purpose, a systematic review of articles about May-Thurner Syndrome and its management therapies, published from January 1, 2005 to September 20, 2015, on PubMED and SCOPUS databases, was carried out. Search terms were “may-thurner syndrome” (medical subject headings [MeSH term]), “iliocaval compression syndrome” (MeSH), “cockett syndrome” (MeSH), “peripheral vascular diseases” (MeSH), and “treatment” (keyword). Of the 89 retrieved studies, 14 met the elegibility criteria. Retrieved studies covered that without correction of this syndrome, patients are at continued risk for recurrent deep vein thrombosis and post-thrombotic syndrome. Considering the therapy, systemic anticoagulation is the first component, and endovascular treatment appears to be superior to conventional surgical treatment. It should be the first line of therapy. Furthermore, there has been multiple advences in the recent years for chronic arterial occlusions using techniques such as blunt micro dissection, radiofrequency energy and laser. In the absence of deep venous trombosis, conservative treatments are preferred. To conclude, based on the review of the literature, a combination of conservative and endovascular therapy usually provides the best treatment in most cases. Thus, further researches must be done to advance in the matter of therapeutic of the non-DVT form of May-Thurner Syndrome.   Keywords: May-Thurner Syndrome, Iliocaval Compression Syndrome, Cockett Syndrome, Peripheral Vascular Disease, Treatment.

scholarly journals Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel therapeutic approach

Mitochondrion ◽  
2013 ◽  
Vol 13 (5) ◽  
pp. 515-519 ◽  
Author(s):  
Ahmad Ghanizadeh ◽  
Michael Berk ◽  
Hassan Farrashbandi ◽  
Ali Alavi shoushtari ◽  
Kristi-Ann Villagonzalo
Keyword(s):  
Systematic Review ◽  
Electron Transport ◽  
Therapeutic Approach ◽  
Electron Transport Chain ◽  
Mitochondrial Electron Transport Chain ◽  
Transport Chain ◽  
Novel Therapeutic
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