scholarly journals Topical AC-11 abates actinic keratoses and early squamous cell cancers in hairless mice exposed to Ultraviolet A (UVA) radiation

2015 ◽  
Vol 21 (4) ◽  
Author(s):  
Julian M Mentor ◽  
Amir Etemadi ◽  
Abrienne M Patta ◽  
Noah Scheinfeld
Keyword(s):  
Squamous Cell ◽  
Ultraviolet A ◽  
Hairless Mice ◽  
Actinic Keratoses ◽  
Uva Radiation

Ocular effects of treatment with various psoralen derivatives and ultraviolet-A(UVA) radiation in HRA/Skh hairless mice

2009 ◽  
Vol 64 (4) ◽  
pp. 471-478 ◽  
Author(s):  
Felix M. Barker ◽  
Pierrette Dayhaw-Barker ◽  
P. Donald Forbes ◽  
Ronald E. Davies
Keyword(s):  
Ultraviolet A ◽  
Hairless Mice ◽  
Psoralen Derivatives ◽  
Uva Radiation

Multiple Large-Surface Photodynamic Therapy Sessions with Topical or Systemic Aminolevulinic Acid and Blue Light in UV-Exposed Hairless Mice

2004 ◽  
Vol 8 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Younan Liu ◽  
Gilles Viau ◽  
Robert Bissonnette
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Blue Light ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Aminolevulinic Acid ◽  
Hairless Mice ◽  
Free Survival ◽  
Actinic Keratoses

Background: The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. Objective: The current study compared the ability of topical and systemic ALA–PDT as well as topical ALA–PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model. Methods: Groups of hairless mice were exposed daily to UV radiation and weekly to ALA–PDT. Tumor-free survival was compared for mice exposed to UV and treated weekly with ALA–PDT and mice exposed only to UV radiation. Results: Weekly topical or systemic ALA–PDT was able to delay the induction of skin tumors. A significant difference in tumor-free survival was also observed for both actinic keratoses and invasive squamous cell carcinoma in mice treated weekly with topical ALA–PDT performed with blue light. This was observed even when weekly ALA–PDT was started after 8 weeks of UV exposure. Conclusion: Large-surface topical ALA–PDT with blue light can delay the appearance of UV-induced actinic keratoses and squamous cell carcinoma in hairless mice.

Are actinic keratoses really squamous cell cancer? How do we know if they would become malignant?

2018 ◽  
Vol 36 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Claudio Conforti ◽  
Emanuela Beninati ◽  
Caterina Dianzani
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Actinic Keratoses

scholarly journals 5-Aminolevulinic Acid-Based Photodynamic Therapy Pretreatment Mitigates Ultraviolet A-Induced Oxidative Photodamage

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Hui Hua ◽  
Jiawei Cheng ◽  
Wenbo Bu ◽  
Juan Liu ◽  
Weiwei Ma ◽  
...  
Keyword(s):  
Aminolevulinic Acid ◽  
Epidermal Keratinocytes ◽  
Control Group ◽  
Hacat Cells ◽  
Ultraviolet A ◽  
Hairless Mice ◽  
Human Epidermal Keratinocytes ◽  
Experimental Group

Aim. To determine whether 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) is effective in combating ultraviolet A- (UVA-) induced oxidative photodamage of hairless mice skin in vivo and human epidermal keratinocytes in vitro. Methods. In in vitro experiments, the human keratinocyte cell line (HaCaT cells) was divided into two groups: the experimental group was treated with ALA-PDT and the control group was left untreated. Then, the experimental group and the control group of cells were exposed to 10 J/m2 of UVA radiation. ROS, O2− species, and MMP were determined by fluorescence microscopy; p53, OGG1, and XPC were determined by Western blot analysis; apoptosis was determined by flow cytometry; and 8-oxo-dG was determined by immunofluorescence. Moreover, HaCaT cells were also treated with ALA-PDT. Then, SOD1 and SOD2 were examined by Western blot analysis. In in vivo experiments, the dorsal skin of hairless mice was treated with ALA-PDT or saline-PDT, and then, they were exposed to 20 J/m2 UVA light. The compound 8-oxo-dG was detected by immunofluorescence. Conclusion. In human epidermal keratinocytes and hairless mice skin, UVA-induced oxidative damage can be prevented effectively with ALA-PDT pretreatment.

scholarly journals Malignant transformation of actinic keratoses to squamous cell carcinoma in an albino

2009 ◽  
Vol 54 (1) ◽  
pp. 46 ◽  
Author(s):  
DevinderMohan Thappa ◽  
VijayaSivalingam Ramalingam ◽  
Ramapriya Sinnakirouchenan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Actinic Keratoses

scholarly journals Actinic keratoses and basal and squamous cell carcinomas in elderly people: clinical aspects

2010 ◽  
Vol 10 (S1) ◽  
Author(s):  
U Bottoni ◽  
T Vitagliano ◽  
F G Amoruso ◽  
M Greco ◽  
M A Fiorillo
Keyword(s):  
Elderly People ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Clinical Aspects ◽  
Actinic Keratoses

The characterization of squamous cell carcinoma induced by ultraviolet irradiation in hairless mice

Pathology ◽  
1988 ◽  
Vol 20 (2) ◽  
pp. 109-117 ◽  
Author(s):  
P.J. Canfield ◽  
G.E. Greenoak ◽  
V.E. Reeve ◽  
C.H. Gallagher ◽  
E.N. Macasaet
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ultraviolet Irradiation ◽  
Hairless Mice
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