Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas

1995 ◽  
Vol 131 (7) ◽  
pp. 796-800 ◽  
Author(s):  
J. M. Spencer
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Actinic Keratoses ◽  
Ras Genes

scholarly journals Actinic keratoses and basal and squamous cell carcinomas in elderly people: clinical aspects

2010 ◽  
Vol 10 (S1) ◽  
Author(s):  
U Bottoni ◽  
T Vitagliano ◽  
F G Amoruso ◽  
M Greco ◽  
M A Fiorillo
Keyword(s):  
Elderly People ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Clinical Aspects ◽  
Actinic Keratoses

The Majority of Cutaneous Squamous Cell Carcinomas Arise in Actinic Keratoses

2002 ◽  
Vol 6 (3) ◽  
pp. 207-209 ◽  
Author(s):  
D. Czarnecki ◽  
C. J. Meehan ◽  
F. Bruce ◽  
G. Culjak
Keyword(s):  
Family History ◽  
Squamous Cell ◽  
Retrospective Studies ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
Histological Features ◽  
Actinic Keratoses ◽  
Skin Cancers ◽  
History Of ◽  
A Prospective Study

Background: Retrospective studies have given conflicting results with respect to how many cutaneous squamous cell carcinomas (SCCs) arise in actinic keratoses (AK). Objective: This study was conducted to determine what percentage of SCCs arise in AKs and to obtain more information about two histological features of SCCs, namely, thickness and ulceration. Methods: A prospective study was done of all SCCs treated by the authors during one calendar year. Results: Two hundred eight patients with SCC were entered into the study. An AK was contiguous with an SCC in 72% of the cases. This was taken as evidence that the SCC arose in the AK. Men presented with thicker and more ulcerated SCCs than women, but these were not statistically significant: p = 0.06 for thickness and p = 0.07 for ulceration. Ulcerated SCCs were more likely to arise on the head and neck (p = 0.02), on patients who had multiple skin cancers ( p = 0.005), and on patients who had a family history of skin cancer ( p = 0.03). Conclusion: Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

scholarly journals Neoantigen Fitness Model Predicts Lower Immune Recognition of Cutaneous Squamous Cell Carcinomas Than Actinic Keratoses

2019 ◽  
Vol 10 ◽  
Author(s):  
Elizabeth S. Borden ◽  
Paul Kang ◽  
Heini M. Natri ◽  
Tanya N. Phung ◽  
Melissa A. Wilson ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Immune Recognition ◽  
Actinic Keratoses

Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions

1996 ◽  
Vol 25 (5) ◽  
pp. 232-238 ◽  
Author(s):  
H. Matsuda ◽  
N. Konishi ◽  
Y. Hiasa ◽  
I. Hayashi ◽  
T. Tsuzuki ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Premalignant Lesions ◽  
Oral Squamous Cell Carcinomas ◽  
Ras Genes
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