scholarly journals Abnormal Gastroesophageal Flap Valve Is Associated With High Gastresophageal Reflux Disease Questionnaire Score and the Severity of Gastroesophageal Reflux Disease in Vietnamese Patients With Upper Gastrointestinal Symptoms

2018 ◽  
Vol 24 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Duc T Quach ◽  
Trang T Nguyen ◽  
Toru Hiyama
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Gastrointestinal Symptoms ◽  
Questionnaire Score ◽  
Upper Gastrointestinal Symptoms ◽  
Reflux Disease Questionnaire ◽  
Upper Gastrointestinal ◽  
Disease Questionnaire ◽  
Flap Valve

scholarly journals Acute Effects of Red Chili, a Natural Capsaicin Receptor Agonist, on Gastric Accommodation and Upper Gastrointestinal Symptoms in Healthy Volunteers and Gastroesophageal Reflux Disease Patients

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3740
Author(s):  
Tanisa Patcharatrakul ◽  
Chatchai Kriengkirakul ◽  
Tawatchai Chaiwatanarat ◽  
Sutep Gonlachanvit
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Healthy Volunteers ◽  
Reflux Disease ◽  
Gastrointestinal Symptoms ◽  
Emission Computed Tomography ◽  
Transient Receptor Potential Vanilloid ◽  
Gastric Accommodation ◽  
Upper Gastrointestinal Symptoms ◽  
Upper Gastrointestinal

The effects of chili on gastric accommodation (GA) in gastroesophageal reflux disease (GERD) patients have not been explored. Methods: In total, 15 healthy volunteers (HV) and 15 pH-positive non-erosive GERD (NERD) patients underwent single-photon emission computed tomography after ingesting 2 g of chili or placebo in capsules in a randomized double-blind crossover fashion with a one-week washout period. GA was the maximal postprandial gastric volume (GV) after 250 mL of Ensure® minus the fasting GV. Upper gastrointestinal symptoms were evaluated by using a visual analog scale. Results: NERD patients but not HV had significantly greater GA after chili compared to a placebo (451 ± 89 vs. 375 ± 81 mL, p < 0.05). After chili, the postprandial GVs at 10, 20, and 30 min in NERD patients were significantly greater than HV (10 min, 600 ± 73 vs. 526 ± 70 mL; 20 min, 576 ± 81 vs. 492 ± 78 mL; 30 min, 532 ± 81 vs. 466 ± 86 mL, all p < 0.05). In NERD, chili was associated with significantly less satiety, more severe abdominal burning (p < 0.05), and a trend of more severe heartburn (p = 0.06) compared to the placebo. In HV, postprandial symptoms after chili and placebo ingestion were similar (p > 0.05). Conclusions: Chili enhanced GA in NERD patients but not in HV. This suggests that the modulation of GA in NERD is abnormal and likely involves transient receptor potential vanilloid 1 (TRPV1) sensitive pathways.

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