Should Tamiflu™ be stockpiled locally?

2006 ◽  
Vol 4 (3) ◽  
pp. 21
Author(s):  
Sandro Cinti, MD ◽  
Gerald Blackburn, DO
Keyword(s):  
United States ◽  
Avian Influenza ◽  
Hurricane Katrina ◽  
Local Governments ◽  
Influenza Pandemic ◽  
The United States ◽  
H5n1 Avian Influenza ◽  
Control And Prevention ◽  
Federal Response

The outbreak of H5N1 avian influenza in Asia raises serious concerns about an influenza pandemic of the kind seen in 1918. In addition, the recent federal response to Hurricane Katrina highlights the need for advanced local preparation for biological disasters. It is clear that there will not be enough vaccine early in an influenza pandemic. Without vaccine, the role of antivirals, especially oseltamivir (Tamiflu™), in treatment and prophylaxis becomes of paramount importance. It is unlikely that the Centers for Disease Control and Prevention (CDC) will be able to stockpile enough oseltamivir to protect every first responder in the United States. Thus, it is important that local governments and hospitals consider stockpiling oseltamivir for the treatment and/or prophylaxis of local first responders.

Preparing for Pandemic Influenza: Should Hospitals Stockpile Oseltamivir?

2005 ◽  
Vol 26 (11) ◽  
pp. 852-854 ◽  
Author(s):  
Sandro Cinti ◽  
Carol Chenoweth ◽  
Arnold S. Monto
Keyword(s):  
United States ◽  
Influenza Pandemic ◽  
Antiviral Agents ◽  
The United States ◽  
Short Supply ◽  
H5n1 Avian Influenza ◽  
Reasonable Cost ◽  
The Government

AbstractThe outbreak of H5N1 avian influenza in Asia has reignited concerns about an influenza pandemic. It is clear that influenza vaccine will be in short supply (or nonexistent) early in an influenza pandemic. Without vaccine, the role of antiviral agents, especially oseltamivir, in treatment and prophylaxis is of paramount importance. Unfortunately, the government cannot possibly stockpile enough oseltamivir to provide long-term prophylaxis or treatment for every healthcare worker in the United States. We think that hospitals should consider stockpiling oseltamivir, and we provide a strategy for doing so at a reasonable cost.

scholarly journals Overcoming the barriers to green procurement in the county: Interest groups and administrative professionalism

2016 ◽  
Vol 16 (3) ◽  
pp. 259-285 ◽  
Author(s):  
Christy Smith ◽  
Jessica Terman
Keyword(s):  
Climate Change ◽  
United States ◽  
Interest Groups ◽  
Local Governments ◽  
The United States ◽  
Green Procurement ◽  
Environmentally Responsible ◽  
Government Involvement ◽  
Mitigate Climate Change

Scholars and practitioners have come to understand the important role of local governments in the causes and effects of climate change. The literature has examined both the substantive and symbolic determinants of urban sustainability policies in addition to the implementation issues associated with those policies. At the heart of these policies is the idea that local governments have the desire and ability to engage in socially and environmentally responsible practices to mitigate climate change. While important, these studies are missing a key component in the investigation of local government involvement in sustainability policies: government purchasing power. This study examines the effect of administrative professionalism and interest group presence on the determinants of green procurement in the understudied context of counties in the United States.

scholarly journals Pandemic H1N1 influenza: predicting the course of a pandemic and assessing the efficacy of the planned vaccination programme in the United States

2009 ◽  
Vol 14 (41) ◽  
Author(s):  
S Towers ◽  
Z Feng
Keyword(s):  
United States ◽  
Influenza A ◽  
Influenza Pandemic ◽  
Vaccination Campaign ◽  
H1n1 Influenza ◽  
The United States ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 Influenza ◽  
Influenza A H1n1 ◽  
Control And Prevention

We use data on confirmed cases of pandemic influenza A(H1N1), disseminated by the United States Centers for Disease Control and Prevention(US CDC), to fit the parameters of a seasonally forced Susceptible, Infective, Recovered (SIR) model. We use the resulting model to predict the course of the H1N1 influenza pandemic in autumn 2009, and we assess the efficacy of the planned CDC H1N1 vaccination campaign. The model predicts that there will be a significant wave in autumn, with 63% of the population being infected, and that this wave will peak so early that the planned CDC vaccination campaign will likely not have a large effect on the total number of people ultimately infected by the pandemic H1N1 influenza virus.

scholarly journals California and the 1918–1920 Influenza Pandemic

2020 ◽  
Vol 97 (3) ◽  
pp. 3-36
Author(s):  
Diane M. T. North
Keyword(s):  
United States ◽  
World War I ◽  
Influenza Pandemic ◽  
Medical Science ◽  
The United States ◽  
Virus Spread ◽  
World War ◽  
Military Installations

The 1918–1920 influenza pandemic remains the deadliest influenza pandemic in recorded history. It started in the midst of World War I and killed an estimated 50–100 million people worldwide, many from complications of pneumonia. Approximately 500 million, or one-third of the world's population, became infected. In the United States, an estimated 850,000 died. The exceptionally contagious, unknown strain of influenza virus spread rapidly and attacked all ages, but it especially targeted young adults (ages twenty to forty-four). This essay examines the evolution of four waves of the 1918–1920 influenza pandemic, emphasizes the role of the U.S. Navy and sea travel as the initial transmitters of the virus in the United States, and focuses on California communities and military installations as a case study in the response to the crisis. Although the world war, limited medical science, and the unknown nature of the virus made it extremely difficult to fight the disease, the responses of national, state, and community leaders to the 1918–1920 influenza pandemic can provide useful lessons in 2020, as the onslaught of COVID-19 forces people worldwide to confront a terrible illness and death.

scholarly journals Outcomes of Hospitalized COVID-19 Patients by Risk Factors: Results from a United States Hospital Claims Database

2020 ◽  
Vol 7 (2) ◽  
pp. 165-175 ◽  
Author(s):  
Peter J. Mallow ◽  
Kathy W. Belk ◽  
Michael Topmiller ◽  
Edmond A. Hooker
Keyword(s):  
United States ◽  
Risk Factors ◽  
The United States ◽  
Hospital Length ◽  
Primary Objective ◽  
Hospital Length Of Stay ◽  
Improve Risk Stratification ◽  
Control And Prevention ◽  
Secondary Objective

Background/Objective: The primary objective was to quantify the role of the number of Centers of Disease Control and Prevention (CDC) risk factors on in-hospital mortality. The secondary objective was to assess the associated hospital length of stay (LOS), intensive care unit (ICU) bed utilization, and ICU LOS with the number of CDC risk factors. Methods: A retrospective cohort study consisting of all hospitalizations with a confirmed COVID-19 diagnosis discharged between March 15, 2020 and April 30, 2020 was conducted. Data was obtained from 276 acute care hospitals across the United States. Cohorts were identified based upon the number of the CDC COVID-19 risk factors. Multivariable regression modeling was performed to assess outcomes and utilization. The odds ratio (OR) and incidence rate ratio (IRR) were reported. Results: Compared with patients with no CDC risk factors, patients with risk factors were significantly more likely to die during the hospitalization: One risk factor (OR 2.08, 95% CI, 1.60–2.70; P < 0.001), two risk factors (OR 2.63, 95% CI, 2.00–3.47; P < 0.001), and three or more risk factors (OR 3.49, 95% CI, 2.53–4.80; P < 0.001). The presence of CDC risk factors was associated with increased ICU utilization, longer ICU LOS, and longer hospital LOS compared to those with no risk factors. Patients with hypertension (OR 0.77, 95% CI, 0.70–0.86; P < 0.001) and those administered statins were less likely to die (OR 0.54, 95% CI, 0.49–0.60; P < 0.001). Conclusions: Quantifying the role of CDC risk factors upon admission may improve risk stratification and identification of patients who may require closer monitoring and more intensive treatment.

Measles cases will spur US vaccines debate

2019 ◽  
Keyword(s):  
United States ◽  
New York ◽  
Local Governments ◽  
The United States ◽  
Health Campaigns ◽  
Content Type ◽  
Control And Prevention ◽  
Current Outbreak ◽  
Public Health Campaigns ◽  
Media Firms

Subject Measles cases and vaccinations in the United States. Significance The Centers for Disease Control and Prevention said in late May there had been 971 reported cases of measles in 2019, surpassing the previous US record of 963 in 1994. Measles is highly contagious but had been eliminated in the United States in 2000. Now, however, it is back. The current outbreak is particularly affecting parts of New York City and within that, the Orthodox Jewish community. Impacts Social media firms could face government and public pressure further to help with public health campaigns. There will likely be court cases against local governments’ legal moves to compel people to be vaccinated. If vaccination levels do not increase markedly, inroads could be created into the problem by increasing US border health checks.

Currents in Contemporary Ethics

2006 ◽  
Vol 34 (3) ◽  
pp. 620-623 ◽  
Author(s):  
Barry DeCoster
Keyword(s):  
United States ◽  
Health Care ◽  
Avian Influenza ◽  
Influenza Vaccine ◽  
Influenza Pandemic ◽  
The United States ◽  
Health Care Rationing ◽  
The Public ◽  
Care Rationing

The flu has an interesting history with respect to health care rationing in the United States. Consider that just about two years ago, the American public faced a shortage of influenza vaccine. Dire predictions were made about how many people might perish, and rationing protocols were created. However, many of the rationing protocols were ignored. Luckily, that flu season did not result in the horrible fatalities that were predicted. For these reasons, problems of health care rationing around issues of the flu were postponed, rather than resolved.Over the last year, the public has focused its anxious attention on the possible avian influenza pandemic. Last week I noticed that at least once each day I heard mention in some discussion or another of the threat of this disease becoming easily transmissible from human to human.

scholarly journals Understanding the Role of Planners in Wildfire Preparedness and Mitigation

ISRN Forestry ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Menka Bihari ◽  
Elisabeth M. Hamin ◽  
Robert L. Ryan
Keyword(s):  
United States ◽  
Land Use ◽  
Emergency Management ◽  
Local Governments ◽  
Regulatory Authority ◽  
The United States ◽  
Federal Agencies ◽  
Residential Areas ◽  
Wildland Urban Interface

As wildfires affect more residential areas across the United States, the need for collaboration between land managers, federal agencies, neighbours, and local governments has become more pressing especially in the context of the wildland-urban interface. Previous research has not focused much on land-use planners’ role in wildfire mitigation. This paper provides information on how land-use planners can assist communities in learning to live with wildfire risk through planning, preparedness, and mitigation efforts in the wildland-urban interface (WUI). Based on interviews with land-use planners, forest planners, and local emergency management officials, we identified a range of tools that could be used for improving wildfire preparedness and mitigation initiatives in the WUI, but also found that planners felt that they lacked the regulatory authority to use these tenaciously. The paper also identifies a range of possible actions that would contribute towards safer building practices in the interface communities.

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