Revisiting the 1970 smallpox outbreak in Meschede, Germany: Lessons for a post-COVID world

2021 ◽  
Vol 19 (7) ◽  
pp. 157-163
Author(s):  
Promise Tewogbola, MS ◽  
Norah Aung, MS

When people think about hazards, the types that easily come to their mind include natural hazards, such as earthquakes, tornados, and tsunamis, and manmade ones, such as plane crashes, bomb explosions, and exposure to toxic industrial chemicals. Disease outbreaks are a source of hazards that are often overlooked, and the largely forgotten smallpox was an example of such disease. This article provides a review of the emergency management practices that curtailed the potentially devastating spread of smallpox at Meschede, Germany in 1970. Lessons that can be transferred to the COVID-19 pandemic are also discussed.

Author(s):  
Irfan Aziz ◽  
Birendra Shrivastava ◽  
Chandana Venkateswara Rao2 ◽  
Sadath Ali

Liver disease or liver cancer is the sixth most common cancer and the third leading cause of cancer mortality in the world. Hepatitis viral infection, food additives, alcohol, fungal toxins (aflatoxins), toxic industrial chemicals, air and water pollutants are the major risk factors of liver cancer. Moreover, due to high tolerance of liver, HCC is seldom detected at an early stage and once detected treatment faces a poor prognosis in most cases.Fumaria indica possesses hepatoprotective activity as evidenced by the significant and dose dependent restoring the activities of entire liver cancer marker enzymes, diminution in tumor incidence, decrease in lipid peroxidation (LPO) and increase in the level of antioxidant enzymes (GSH, CAT, SOD, GPx and GST) through scavenging of free radicals, or by enhancing the activity of antioxidant, which then detoxify free radicals. These factors protect cells from ROS damage in NDEA and CCl4-induced hepatocarcinogenesis. Histopathological observations of liver tissues too correlated with the biochemical observations. Thus, present investigation suggested that the Fumaria indica would exert a chemoprotective effect by reversing the oxidant-antioxidant imbalance during hepatocarcinogenesis induced by NDEA and CCl4. Besides Fumaria indicais very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes. The hepatoprotective activity of a Fumaria indicaof 50 % ethanolic extract was studied using rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt. Fumaria indica extract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEAand CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Fumaria indicaextract against carbon tetrachlorideand N-nitrosodiethylamine induced hepatotoxicity in rats. In addition to this, studies on molecular aspect of hepatoprotective therapy will give mechanistic information in hepatoprotective therapy and also critical balance should be there between the animal model and clinical research. The hepatoprotective properties of Fumaria indicashould provide useful information in the possible application in hepatic liver disease.


Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5045
Author(s):  
Victor Bocos-Bintintan ◽  
Ileana Andreea Ratiu

Sensitive real-time detection of vapors produced by toxic industrial chemicals (TICs) always represents a stringent priority. Hydrogen cyanide (HCN) is definitely a TIC, being widely used in various industries and as an insecticide; it is a reactive, very flammable, and highly toxic compound that affects the central nervous system, cardiovascular system, eyes, nose, throat, and also has systemic effects. Moreover, HCN is considered a blood chemical warfare agent. This study was focused toward quick detection and quantification of HCN in air using time-of-flight ion mobility spectrometry (ToF IMS). Results obtained clearly indicate that IMS can rapidly detect HCN at sub-ppmv levels in air. Ion mobility spectrometric response was obtained in the negative ion mode and presented one single distinct product ion, at reduced ion mobility K0 of 2.38 cm2 V−1 s−1. Our study demonstrated that by using a miniaturized commercial IMS system with nonradioactive ionization source model LCD-3.2E (Smiths Detection Ltd., London, UK), one can easily measure HCN at concentrations of 0.1 ppmv (0.11 mg m−3) in negative ion mode, which is far below the OSHA PEL-TWA value of 10 ppmv. Measurement range was from 0.1 to 10 ppmv and the estimated limit of detection LoD was ca. 20 ppbv (0.02 mg m−3).


2020 ◽  
Vol 18 (7) ◽  
pp. 177-182
Author(s):  
Kevin Kupietz, PhD ◽  
Lesley Gray, MPH

Introduction: The greatest enemy of a global pandemic is not the virus itself, but the fear, rumor, and stigma that envelopes people. This article explores the context and history of fear and stigma relating to pandemic, summarizing key actions to mitigate the harms during an active pandemic.Method: Our article draws from accounts in literature and journalist accounts documenting the relationship between infectious diseases and major disease outbreaks that have garnered fear and stigmatization. Results: Fear, stigma, and discrimination are not new concepts for pandemics. These social effects run the risk of diverting attention from the presenting disease and government responses. Reactions to fear, stigma, and discrimination risk sabotaging effective efforts to contain, manage, and eradicate the disease.Conclusion: Emergency managers have an important role in dispelling myths, disseminating appropriate and evidence-based information without exacerbating fears. Knowledge about the roots of fear and bias along with a good understanding of historical plagues and pandemics is vital to ensure those in the field of emergency management can effectively manage irrational fears.


2012 ◽  
Vol 27 (5) ◽  
pp. 425-431 ◽  
Author(s):  
Pascale Ribordy ◽  
David Rocksén ◽  
Uno Dellgar ◽  
Sven-Åke Persson ◽  
Kristina Arnoldsson ◽  
...  

AbstractIntroductionMobile decontamination units are intended to be used at the accident site to decontaminate persons contaminated by toxic substances. A test program was carried out to evaluate the efficacy of mobile decontamination units.ObjectiveThe tests included functionality, methodology, inside environment, effects of wind direction, and decontamination efficacy.MethodsThree different types of units were tested during summer and winter conditions. Up to 15 test-persons per trial were contaminated with the imitation substances Purasolve ethyl lactate (PEL) and methyl salicylate (MES). Decontamination was carried out according to standardized procedures. During the decontamination trials, the concentrations of the substances inside the units were measured. After decontamination, substances evaporating from test-persons and blankets as well as remaining amounts in the units were measured.ResultsThe air concentrations of PEL and MES inside the units during decontamination in some cases exceeded short-term exposure limits for most toxic industrial chemicals. This was a problem, especially during harmful wind conditions, i.e., wind blowing in the same direction as persons moving through the decontamination units. Although decontamination removed a greater part of the substances from the skin, the concentrations evaporating from some test-persons occasionally were high and potentially harmful if the substances had been toxic. The study also showed that blankets placed in the units absorbed chemicals and that the units still were contaminated five hours after the end of operations.ConclusionsAfter decontamination, the imitation substances still were present and evaporating from the contaminated persons, blankets, and units. These results indicate a need for improvements in technical solutions, procedures, and training.RibordyP, RocksénD, DellgarU, PerssonS, ArnoldssonK, EkåsenH, HäggbomS, NerfO, LjungqvistA, GrythD, ClaessonO. Mobile decontamination units—room for improvement?. Prehosp Disaster Med.2012;27(4):1–7.


2019 ◽  
Vol 1 ◽  
pp. 1-1
Author(s):  
Harrison Cole

<p><strong>Abstract.</strong> The near future of our planet under climate change is predicted to be characterized by increasingly frequent and severe natural hazards of all kinds. Understanding the potential spatial extent and impacts of these hazards is a critical component of creating effective emergency management plans, not just on the part of emergency managers and relief organizations, but also for those who may reside in areas vulnerable to disaster. Often, information about disaster risk is communicated using maps, such as in the case of storm surge maps, evacuation zone maps or wildfire extent maps. While generally helpful, these maps are of limited use to those with low vision or blindness, and the information is rarely, if ever, distributed in accessible formats. Furthermore, in contrast to wayfinding maps, this type of information does not lend itself to being translated into a set of instructions to be read aloud by a test-to-speech device. Instead, risk maps are useful because they allow users to identify and assess spatial relationships between many features on the maps- a key process that would be muddled if the maps were to be verbally described, and thus a process that is currently inaccessible to those who cannot see the maps. As people with visual impairments are especially vulnerable in disaster scenarios, working towards the universal accessibility of spatial information is imperative for inclusive disaster preparedness and hazard mitigation.</p><p>Many challenges exist in creating maps for people with visual impairments. The most obvious is the fact that a visual medium cannot be used by someone who is unable to see. It is important to note that “visual impairment” covers a broad spectrum of conditions from pronounced myopia to complete blindness. Here, I will be limiting my topical scope to people with total or near-total blindness. Tactile maps are the tool of choice for this population. However, it is generally harder to distinguish between similar patterns using touch than using sight, so features on a tactile map need to be unique and unambiguous. This makes it more challenging to communicate information typically represented using color gradients or transparency. Additionally, distributing spatial information in tactile form poses another layer of complications. There are several options for creating tactile maps, from embossed paper to 3D printing, and each come with their own advantages and drawbacks. Cost, speed and detail all vary among these media, and thus each potentially impact the user’s perception of risk.</p><p> In my talk, I will be examining these challenges as they intersect with research on cartographic risk visualization, emergency management, and tactile maps in general. First, I will briefly discuss the state of risk visualization in the context of emergency management, focusing on preparedness. Then, I will give a general overview of the extant research on tactile maps with particular attention paid to their influence on spatial cognition. Next, I will examine how the considerations particular to risk map creation are affected by the potentials and limitations of tactile maps. Finally, I will outline a research agenda for creating and distributing accessible maps for emergency management. Using visual impairment and tactile maps as starting points, I will identify further aspects of emergency management that urgently require greater attention to accessibility, and how cartographic research and technology can help bridge those gaps.</p><p> Planning for natural hazards is an essential step in mitigating their impacts on communities, and that process includes individual citizens making their own plans for evacuation, finding shelter or securing food, water or medicine. This is especially important for people with disabilities, as resources deployed after a disaster may fail to accommodate their particular needs, and processes such as evacuating a building or house can take substantially longer than average. Planning for these scenarios is made all the more difficult for people with visual impairments, as conventional maps are unhelpful, and environmental awareness is limited. Thus, empowering people with visual impairments to make emergency plans for themselves and contribute to planning for their community as a whole can help build autonomy and self-confidence and ultimately ensure that disaster plans truly account for everyone.</p>


2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jennifer B. Nuzzo ◽  
Diane Meyer ◽  
Michael Snyder ◽  
Sanjana J. Ravi ◽  
Ana Lapascu ◽  
...  

Abstract Background The 2014–2016 Ebola outbreak was a wake-up call regarding the critical importance of resilient health systems. Fragile health systems can become overwhelmed during public health crises, further exacerbating the human, economic, and political toll. Important work has been done to describe the general attributes of a health system resilient to these crises, and the next step will be to identify the specific capacities that health systems need to develop and maintain to achieve resiliency. Methods We conducted a scoping review of the literature to identify recurring themes and capacities needed for health system resiliency to infectious disease outbreaks and natural hazards and any existing implementation frameworks that highlight these capacities. We also sought to identify the overlap of the identified themes and capacities with those highlighted in the World Health Organization’s Joint External Evaluation. Sources of evidence included PubMed, Web of Science, OAIster, and the websites of relevant major public health organizations. Results We identified 16 themes of health system resilience, including: the need to develop plans for altered standards of care during emergencies, the need to develop plans for post-event recovery, and a commitment to quality improvement. Most of the literature described the general attributes of a resilient health system; no implementation frameworks were identified that could translate these elements into specific capacities that health system actors can employ to improve resilience to outbreaks and natural hazards in a variety of settings. Conclusions An implementation-oriented health system resilience framework could help translate the important components of a health system identified in this review into specific capacities that actors in the health system could work to develop to improve resilience to public health crises. However, there remains a need to further refine the concept of resilience so that health systems can simultaneously achieve sustainable transformations in healthcare practice and health service delivery as well as improve their preparedness for emergencies.


2020 ◽  
Vol 12 (6) ◽  
pp. 2223 ◽  
Author(s):  
Sheng Liu ◽  
Jian Ge ◽  
Wangming Li ◽  
Ming Bai

The historic environmental vulnerability of traditional villages (HEVTVs) is distinctly differentiated; however, the priority of relevant emergency management practices still lacks appropriate evaluation. This study proposes a new assessment system to quantify HEVTVs at the district level and an extended analysis of the influencing factors of adaptive capacity. This provides a basis to classify the emergency management of villages under geological hazard risks. Based on the coupled human–environment system, this research designed the assessment with three criteria, six factors, and 13 indexes from the perspective of HEVTVs. Furthermore, a demonstration test was conducted of 148 traditional villages in Lishui, China. The results showed that 64.19% of HEVTVs in Lishui were moderate or above, and that villages with very high vulnerability were mainly distributed at mid-elevation of mountains with strongly sloping terrain. In contrast, low-vulnerability villages were generally on plains at low altitudes. Furthermore, three high-vulnerability clustering groups were identified as critical improvement targets for which special zoning strategies should be proposed. Five influencing factors were found to be strongly related to the adaptive capacity, indicating a spatial variation of the impact intensity. This could be applied to streamline vulnerability optimization strategies according to local conditions.


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