scholarly journals Structure and anti-M.leprae activity relationships of new quinolones

2009 ◽  
Vol 78 (1) ◽  
pp. 17-23
Author(s):  
Masaichi GIDOH
Keyword(s):  
New Quinolones

In Vitro Activity of New Quinolones against Anaerobic Bacteria

Drugs ◽  
1995 ◽  
Vol 49 (Supplement 2) ◽  
pp. 233-234
Author(s):  
Carl Erik Nord ◽  
Ann Lindmark ◽  
Ingela Persson
Keyword(s):  
Anaerobic Bacteria ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
New Quinolones

scholarly journals In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System

1999 ◽  
Vol 43 (5) ◽  
pp. 1091-1097 ◽  
Author(s):  
Hideki Kita ◽  
Hirotami Matsuo ◽  
Hitomi Takanaga ◽  
Junichi Kawakami ◽  
Koujirou Yamamoto ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Threshold Concentration ◽  
Current Response ◽  
Drug Induced ◽  
Inhibition Ratio ◽  
New Quinolones ◽  
The Central Nervous System ◽  
Anti Inflammatory

ABSTRACT We investigated the correlation between an in vivo isobologram based on the concentrations of new quinolones (NQs) in brain tissue and the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) for the occurrence of convulsions in mice and an in vitro isobologram based on the concentrations of both drugs for changes in the γ-aminobutyric acid (GABA)-induced current response in Xenopus oocytes injected with mRNA from mouse brains in the presence of NQs and/or NSAIDs. After the administration of enoxacin (ENX) in the presence or absence of felbinac (FLB), ketoprofen (KTP), or flurbiprofen (FRP), a synergistic effect was observed in the isobologram based on the threshold concentration in brain tissue between mice with convulsions and those without convulsions. The three NSAIDs did not affect the pharmacokinetic behavior of ENX in the brain. However, the ENX-induced inhibition of the GABA response in the GABAA receptor expressed in Xenopus oocytes was enhanced in the presence of the three NSAIDs. The inhibition ratio profiles of the GABA responses for both drugs were analyzed with a newly developed toxicodynamic model. The inhibitory profiles for ENX in the presence of NSAIDs followed the order KTP (1.2 μM) > FRP (0.3 μM) > FLB (0.2 μM). These were 50- to 280-fold smaller than those observed in the absence of NSAIDs. The inhibition ratio (0.01 to 0.02) of the GABAA receptor in the presence of both drugs was well-fitted to the isobologram based on threshold concentrations of both drugs in brain tissue between mice with convulsions and those without convulsions, despite the presence of NSAIDs. In mice with convulsions, the inhibitory profiles of the threshold concentrations of both drugs in brain tissue of mice with convulsions and those without convulsions can be predicted quantitatively by using in vitro GABA response data and toxicodynamic model.

Celecoxib does not induce convulsions nor does it affect GABAA receptor binding activity in the presence of new quinolones in mice

2005 ◽  
Vol 507 (1-3) ◽  
pp. 69-76 ◽  
Author(s):  
Taiji Yoshino ◽  
Masahiro Noguchi ◽  
Hiroko Okutsu ◽  
Aishi Kimoto ◽  
Masao Sasamata ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Receptor Binding ◽  
Binding Activity ◽  
Receptor Binding Activity ◽  
New Quinolones

Differences between Two New Quinolones (Gemifloxacin and Trovafloxacin) and Ciprofloxacin in Their Concentration-Dependent Killing of Streptococcus pneumoniae

Chemotherapy ◽  
2001 ◽  
Vol 47 (6) ◽  
pp. 409-414 ◽  
Author(s):  
P. Joyanes ◽  
A. Pascual ◽  
M.J. Giménez ◽  
I. García ◽  
L. Aguilar ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
New Quinolones

In Vitro Release of New Quinolones from Biodegradable Systems: A Comparative Study

1996 ◽  
Vol 10 (4) ◽  
pp. 338-347 ◽  
Author(s):  
A. G. Andreopoulos ◽  
T. Korakis ◽  
E. Dounis ◽  
A. Anastasiadis ◽  
P. Tzivelekis ◽  
...  
Keyword(s):  
Comparative Study ◽  
In Vitro Release ◽  
New Quinolones ◽  
Vitro Release

Possible interaction between new quinolones and immune functions in macrophages

1999 ◽  
Vol 32 (5) ◽  
pp. 609-614 ◽  
Author(s):  
Yasutaka Azuma ◽  
Mitsuko Shinohara ◽  
Noboru Murakawa ◽  
Masaki Endo ◽  
Kiyoshi Ohura
Keyword(s):  
Immune Functions ◽  
New Quinolones
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