Differences between Two New Quinolones (Gemifloxacin and Trovafloxacin) and Ciprofloxacin in Their Concentration-Dependent Killing of Streptococcus pneumoniae

Chemotherapy ◽  
2001 ◽  
Vol 47 (6) ◽  
pp. 409-414 ◽  
Author(s):  
P. Joyanes ◽  
A. Pascual ◽  
M.J. Giménez ◽  
I. García ◽  
L. Aguilar ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
New Quinolones

scholarly journals Garenoxacin (BMS-284756) and Moxifloxacin in Experimental Meningitis Caused by Vancomycin-Tolerant Pneumococci

2003 ◽  
Vol 47 (1) ◽  
pp. 211-215 ◽  
Author(s):  
Violeta Rodriguez-Cerrato ◽  
Cindy C. McCoig ◽  
Jesus Saavedra ◽  
Tess Barton ◽  
Ian C. Michelow ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Body Weight ◽  
Streptococcus Pneumoniae ◽  
Pneumococcal Meningitis ◽  
Young Male ◽  
Multidrug Resistant ◽  
Pneumococcal Strain ◽  
New Zealand White Rabbits ◽  
New Quinolones ◽  
Resistant Strains

ABSTRACT The emergence of multidrug-resistant strains of Streptococcus pneumoniae drives the development and evaluation of new antipneumococcal agents, especially for the treatment of bacterial meningitis. The aims of the present study were to assess the antibacterial effectiveness of two new quinolones, garenoxacin (BMS; BMS-284756) and moxifloxacin (MOX) in experimental meningitis caused by a vancomycin (VAN)-tolerant S. pneumoniae strain and to compare the results with those obtained by therapy with VAN and ceftriaxone (CRO) in combination. Meningitis was induced in young male New Zealand White rabbits by intracisternal inoculation of a VAN-tolerant pneumococcal strain (strain Tupelo) from a child with meningitis. Sixteen hours after inoculation, therapy was given by intravenous administration of BMS at 20 mg/kg of body weight, followed 5 h later by administration at a dosage of 10 mg/kg (n = 9 animals) or MOX as two doses of 20 mg/kg every 5 h (n = 8 animals). For comparison, we studied the following groups: (i) animals treated with VAN (20 mg/kg every 5 h, three doses) and CRO (125 mg/kg, one dose) (n = 9), (ii) animals infected with a VAN-tolerant strain but not treated (n = 8), (iii) animals infected with a VAN-tolerant pneumococcus isolated from the nasopharynx of a carrier and treated with BMS (n = 8), and (iv) animals infected with a cephalosporin-resistant type 6B S. pneumoniae strain and treated with BMS (n = 6). The MICs of penicillin, CRO, VAN, BMS, and MOX for the Tupelo strain were 2, 1, 0.5, 0.06, and 0.03 μg/ml, respectively. The rates of killing of strain Tupelo (the change in the log10 number of CFU per milliliter per hour) in cerebrospinal fluid at 5 h were −0.70 ± 0.35, −0.61 ± 0.44, and −0.49 ± 0.36 for BMS, MOX, and VAN-CRO, respectively. Therapy with BMS and MOX was as effective as therapy with VAN-CRO against VAN-tolerant pneumococcal meningitis in rabbits.

In Vitro Evaluation of the Activity of β-Lactams, New Quinolones, and Other Antimicrobial Agents Against Streptococcus Pneumoniae

1996 ◽  
Vol 2 (4) ◽  
pp. 213-221 ◽  
Author(s):  
Kimiko Ubukata ◽  
Tomoko Muraki ◽  
Atsumi Igarashi ◽  
Yasuko Asahi ◽  
Masatoshi Konno
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Agents ◽  
In Vitro Evaluation ◽  
New Quinolones

Impacto de los serotipos 22F y 33F en la epidemiología y patogénesis de Streptococcus pneumoniae causantes de enfermedad neumocócica invasiva en España

Vacunas ◽  
2019 ◽  
Vol 20 ◽  
pp. 36
Author(s):  
J. Sempere ◽  
F. González-Camacho ◽  
M.D. Vicioso ◽  
I. del Río Menéndez ◽  
J. Yuste ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae
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