scholarly journals The Gut Microbiome: Human Health and Inflammatory Skin Diseases

2020 ◽  
Vol 32 (4) ◽  
pp. 265 ◽  
Author(s):  
Emily A. Mann ◽  
Edward Bae ◽  
Darya Kostyuchek ◽  
Hye Jin Chung ◽  
Jean S. McGee
Keyword(s):  
Human Health ◽  
Gut Microbiome ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals Erratum: The Gut Microbiome: Human Health and Inflammatory Skin Diseases

2020 ◽  
Vol 32 (5) ◽  
pp. 440
Author(s):  
Emily A. Mann ◽  
Edward Bae ◽  
Darya Kostyuchek ◽  
Hye Jin Chung ◽  
Jean S. McGee
Keyword(s):  
Human Health ◽  
Gut Microbiome ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals The Role of Gut Microbiome in Psoriasis: Oral Administration of Staphylococcus aureus and Streptococcus danieliae Exacerbates Skin Inflammation of Imiquimod-Induced Psoriasis-Like Dermatitis

2020 ◽  
Vol 21 (9) ◽  
pp. 3303 ◽  
Author(s):  
Karin Okada ◽  
Yoshiaki Matsushima ◽  
Kento Mizutani ◽  
Keiichi Yamanaka
Keyword(s):  
Gut Microbiome ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Gut Bacteria ◽  
Rrna Gene ◽  
Skin Microbiome ◽  
Inflammatory Skin Diseases ◽  
Fecal Microbiome ◽  
Tnf Α ◽  
Inflammatory Skin

Psoriasis is one of the common chronic inflammatory skin diseases in which inflammatory cytokines such as IL-17 and TNF-α play critical roles. Skin microbiome of psoriasis patients is reported to have elevated Staphylococcus and Streptococcus genus. There are controversial reports about gut microbiome of psoriasis patients, and whether the diversity of bacteria in genus level is decreased or not is still unclear. Moreover, it is not yet known if these gut bacteria would be the cause of the inflammation or the result of the inflammation. We analyzed the gut microbiome of the inflammatory skin model mouse (keratinocyte-specific caspase-1 transgenic (Kcasp1Tg) mouse), by analyzing the 16S rRNA gene. Staphylocuccus aureus and Streptococcus danieliae were abundant in Kcasp1Tg mouse fecal microbiome. These dominant bacteria as well as recessive control bacteria were orally administrated to antibiotic-treated wild type mice, and set up imiquimod-induced psoriasis-like skin inflammation model. The skin inflammation including ear thickness and histopathological findings was analyzed. The exacerbated skin lesions with the elevated levels of TNF-α, IL-17A, IL-17F, and IL-22 were observed in Staphylocuccus aureus and Streptococcus danieliae administrated groups. Our finding suggests that there is affinity between skin inflammation severity and certain gut bacteria leading to a vicious cycle: skin inflammation populates certain gut bacteria which itself worsens the skin inflammation. This is the first report on Staphylocuccus aureus and Streptococcuus danieliae effects in vivo. Not only treating the skin lesion but also treating the gut microbiome could be the future key treatment for inflammatory skin disease such as psoriasis.

scholarly journals High prevalence and little awareness in patients with chronic inflammatory skin diseases and genital involvement

2021 ◽  
Author(s):  
Petra Staubach ◽  
Natascha Plavic‐Radeka ◽  
Adriane Peveling‐Oberhag ◽  
Anna Sohn ◽  
Sebastian Zimmer ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
High Prevalence ◽  
Inflammatory Skin
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