scholarly journals The Role of Gut Microbiome in Psoriasis: Oral Administration of Staphylococcus aureus and Streptococcus danieliae Exacerbates Skin Inflammation of Imiquimod-Induced Psoriasis-Like Dermatitis

2020 ◽  
Vol 21 (9) ◽  
pp. 3303 ◽  
Author(s):  
Karin Okada ◽  
Yoshiaki Matsushima ◽  
Kento Mizutani ◽  
Keiichi Yamanaka
Keyword(s):  
Gut Microbiome ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Gut Bacteria ◽  
Rrna Gene ◽  
Skin Microbiome ◽  
Inflammatory Skin Diseases ◽  
Fecal Microbiome ◽  
Tnf Α ◽  
Inflammatory Skin

Psoriasis is one of the common chronic inflammatory skin diseases in which inflammatory cytokines such as IL-17 and TNF-α play critical roles. Skin microbiome of psoriasis patients is reported to have elevated Staphylococcus and Streptococcus genus. There are controversial reports about gut microbiome of psoriasis patients, and whether the diversity of bacteria in genus level is decreased or not is still unclear. Moreover, it is not yet known if these gut bacteria would be the cause of the inflammation or the result of the inflammation. We analyzed the gut microbiome of the inflammatory skin model mouse (keratinocyte-specific caspase-1 transgenic (Kcasp1Tg) mouse), by analyzing the 16S rRNA gene. Staphylocuccus aureus and Streptococcus danieliae were abundant in Kcasp1Tg mouse fecal microbiome. These dominant bacteria as well as recessive control bacteria were orally administrated to antibiotic-treated wild type mice, and set up imiquimod-induced psoriasis-like skin inflammation model. The skin inflammation including ear thickness and histopathological findings was analyzed. The exacerbated skin lesions with the elevated levels of TNF-α, IL-17A, IL-17F, and IL-22 were observed in Staphylocuccus aureus and Streptococcus danieliae administrated groups. Our finding suggests that there is affinity between skin inflammation severity and certain gut bacteria leading to a vicious cycle: skin inflammation populates certain gut bacteria which itself worsens the skin inflammation. This is the first report on Staphylocuccus aureus and Streptococcuus danieliae effects in vivo. Not only treating the skin lesion but also treating the gut microbiome could be the future key treatment for inflammatory skin disease such as psoriasis.

scholarly journals Features of the Skin Microbiota in Common Inflammatory Skin Diseases

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 962
Author(s):  
Iva Ferček ◽  
Liborija Lugović-Mihić ◽  
Arjana Tambić-Andrašević ◽  
Diana Ćesić ◽  
Ana Gverić Grginić ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Seborrheic Dermatitis ◽  
Bacterial Species ◽  
Clinical Manifestations ◽  
Skin Microbiome ◽  
Bacterial Strains ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Bacterial Microbiome ◽  
Inflammatory Skin

Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly impairing patient appearance and quality of life. Given the yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. The term “microbiome” comprises the totality of microorganisms (microbiota), their genomes, and environmental factors in a particular environment. Changes in human skin microbiota composition and/or functionality are believed to trigger immune dysregulation, and consequently an inflammatory response, thereby playing a potentially significant role in the clinical manifestations and treatment of these diseases. Although cultivation methods have traditionally been used in studies of bacterial microbiome species, a large number of bacterial strains cannot be grown in the laboratory. Since standard culture-dependent methods detect fewer than 1% of all bacterial species, a metagenomic approach could be used to detect bacteria that cannot be cultivated. The skin microbiome exhibits spatial distribution associated with the microenvironment (sebaceous, moist, and dry areas). However, although disturbance of the skin microbiome can lead to a number of pathological conditions and diseases, it is still not clear whether skin diseases result from change in the microbiome or cause such a change. Thus far, the skin microbiome has been studied in atopic dermatitis, seborrheic dermatitis, psoriasis, acne, and rosacea. Studies on the possible association between changes in the microbiome and their association with skin diseases have improved the understanding of disease development, diagnostics, and therapeutics. The identification of the bacterial markers associated with particular inflammatory skin diseases would significantly accelerate the diagnostics and reduce treatment costs. Microbiota research and determination could facilitate the identification of potential causes of skin diseases that cannot be detected by simpler methods, thereby contributing to the design and development of more effective therapies.

scholarly journals Synergistic effect of tolfenamic acid and glycyrrhizic acid on TPA-induced skin inflammation in mice

MedChemComm ◽  
2019 ◽  
Vol 10 (10) ◽  
pp. 1819-1827 ◽  
Author(s):  
Wenfeng Liu ◽  
Shun Huang ◽  
Yonglian Li ◽  
Xi Zheng ◽  
Kun Zhang
Keyword(s):  
Synergistic Effect ◽  
Glycyrrhizic Acid ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Tolfenamic Acid ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

Combinational use of tolfenamic acid and glycyrrhizic acid has importantly enhanced influences on treating inflammatory skin diseases.

scholarly journals Anti-Inflammatory Activity of a Medicinal Herb Extract Mixture, HM-V, on an Animal Model of DNCB-Induced Chronic Skin Inflammation

Plants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1546
Author(s):  
Sungbae Park ◽  
Sangmin Lee ◽  
Youngho Weon ◽  
Taewook Kim ◽  
Hakwon Kim ◽  
...  
Keyword(s):  
Animal Model ◽  
Inflammatory Cytokines ◽  
Skin Diseases ◽  
Skin Inflammation ◽  
Medicinal Herb ◽  
Inflammatory Skin Diseases ◽  
Tnf Α ◽  
Ifn Γ ◽  
Chronic Skin ◽  
Pro Inflammatory Cytokines

Chronic inflammatory skin diseases, such as atopic dermatitis, are caused by the accumulation of immune cells and the overproduction of chemokines, including CCL17 and CCL22, due to the activation of pro-inflammatory cytokines secreted from keratinocytes. In the present study, the inhibitory activity of HM-V on tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ)-induced pro-inflammatory cytokines was examined in human keratinocytes (HaCaTs) and 2,4-dinitrofluorobenzene (DNCB)-induced chronic skin contact dermatitis animal models. Traditional Asian medicinal herb extracts mixture (HM-V), which have been extensively used in Asian medicine, were utilized. In TNF-α/IFN-γ-induced HaCaTs, HM-V strongly inhibited mRNA and protein expression of CCL17 and CCL22 in a concentration-dependent manner. The expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 was also inhibited. Therefore, localized administration of HM-V in the DNCB-induced animal model alleviated immune cell deposition and skin inflammation. The results indicate that HM-V exerts inhibitory effects on keratinocyte production of CCL17 and CCL22. Furthermore, HM-V may be a useful anti-inflammatory agent for the prevention and treatment of inflammatory skin diseases.

scholarly journals Erratum: The Gut Microbiome: Human Health and Inflammatory Skin Diseases

2020 ◽  
Vol 32 (5) ◽  
pp. 440
Author(s):  
Emily A. Mann ◽  
Edward Bae ◽  
Darya Kostyuchek ◽  
Hye Jin Chung ◽  
Jean S. McGee
Keyword(s):  
Human Health ◽  
Gut Microbiome ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

The role of lactobacilli in inhibiting skin pathogens

2021 ◽  
Author(s):  
Lize Delanghe ◽  
Irina Spacova ◽  
Joke Van Malderen ◽  
Eline Oerlemans ◽  
Ingmar Claes ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Skin Diseases ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Inflammatory Skin Diseases ◽  
Cutibacterium Acnes ◽  
Inflammatory Skin ◽  
Skin Conditions

The human skin microbiota forms a key barrier against skin pathogens and is important in modulating immune responses. Recent studies identify lactobacilli as endogenous inhabitants of healthy skin, while inflammatory skin conditions are often associated with a disturbed skin microbiome. Consequently, lactobacilli-based probiotics are explored as a novel treatment of inflammatory skin conditions through their topical skin application. This review focuses on the potential beneficial role of lactobacilli (family Lactobacillaceae) in the skin habitat, where they can exert multifactorial local mechanisms of action against pathogens and inflammation. On one hand, lactobacilli have been shown to directly compete with skin pathogens through adhesion inhibition, production of antimicrobial metabolites, and by influencing pathogen metabolism. The competitive anti-pathogenic action of lactobacilli has already been described mechanistically for common different skin pathogens, such as Staphylococcus aureus, Cutibacterium acnes, and Candida albicans. On the other hand, lactobacilli also have an immunomodulatory capacity associated with a reduction in excessive skin inflammation. Their influence on the immune system is mediated by bacterial metabolites and cell wall-associated or excreted microbe-associated molecular patterns (MAMPs). In addition, lactobacilli can also enhance the skin barrier function, which is often disrupted as a result of infection or in inflammatory skin diseases. Some clinical trials have already translated these mechanistic insights into beneficial clinical outcomes, showing that topically applied lactobacilli can temporarily colonize the skin and promote skin health, but more and larger clinical trials are required to generate in vivo mechanistic insights and in-depth skin microbiome analysis.

The Skin Microbiome in Inflammatory Skin Diseases

2020 ◽  
Vol 9 (2) ◽  
pp. 141-151
Author(s):  
Line Brok Nørreslet ◽  
Tove Agner ◽  
Maja-Lisa Clausen
Keyword(s):  
Skin Diseases ◽  
Skin Microbiome ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 265 ◽  
Author(s):  
Seong Jin ◽  
Hyekyung Ha ◽  
Hyeun-Kyoo Shin ◽  
Chang-Seob Seo
Keyword(s):  
Mast Cells ◽  
Western Blotting ◽  
Skin Diseases ◽  
Hacat Keratinocytes ◽  
Inflammatory Skin Diseases ◽  
Histamine Production ◽  
Tnf Α ◽  
Ifn Γ ◽  
Inflammatory Skin ◽  
Anti Inflammatory

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease. The use of immunomodulatory corticosteroids in AD treatment causes adverse side effects. Therefore, novel natural anti-inflammatory therapeutics are needed. The aim of the present study was to investigate the anti-allergic and anti-inflammatory activities of kuwanon G and morusin. To investigate the effect of kuwanon G and morusin on skin inflammation, enzyme-linked immunosorbent assays (ELISA) to quantitate secreted (RANTES/CCL5), thymus- and activation-regulated chemokine (TARC/CCL17), and macrophage-derived chemokine (MDC/CCL22) were performed, followed by Western blotting to measure the phosphorylation of signal transducer and activator of transcription 1 (STAT1) and nuclear transcription factor-κB (NF-κB) p65 in tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ)-stimulated HaCaT keratinocytes. In order to evaluate the anti-allergic effects, ELISA to quantify histamine and leukotriene C4 (LTC4) production and Western blotting to measure 5-lipoxygenase (5-LO) activation were performed using PMA and A23187-stimulated MC/9 mast cells. Kuwanon G reduced the release of RANTES/CCL5, TARC/CCL17, and MDC/CCL22 via down-regulation of STAT1 and NF-κB p65 signaling in TNF-α and IFN-γ-stimulated HaCaT keratinocytes. Kuwanon G also inhibited histamine production and 5-LO activation in PMA and A23187-stimulated MC/9 mast cells. Morusin inhibited RANTES/CCL5 and TARC/CCL17 secretion via the suppression of STAT1 and NF-κB p65 phosphorylation in TNF-α and IFN-γ-stimulated HaCaT keratinocytes, and the release of histamine and LTC4 by suppressing 5-LO activation in PMA and A23187-stimulated MC/9 mast cells. Kuwanon G and morusin are potential anti-inflammatory mediators for the treatment of allergic and inflammatory skin diseases such as AD.

scholarly journals Positive Influence of Probiotics on the Gut-Skin Axis

2020 ◽  
Vol 1 (1) ◽  
pp. 25-26
Author(s):  
Michael Sticherling
Keyword(s):  
Skin Diseases ◽  
Therapeutic Potential ◽  
Acne Vulgaris ◽  
Skin Inflammation ◽  
Skin Condition ◽  
Positive Influence ◽  
Inflammatory Skin Diseases ◽  
Synthetic Drugs ◽  
Inflammatory Skin ◽  
Diseased State

The existence of a gut-skin axis is supported by increasing evidence, but its translational potential is not widely recognized. Studies linked inflammatory skin diseases to an imbalanced gut microbiome; hence, the modulation of the gut microbiota to improve skin condition seems to be a feasible approach. Today, there is a growing interest in natural products as alternatives to synthetic drugs. In this respect, oral probiotics could be a simple, safe and cheap modality in the therapeutic management of skin inflammation. Unfortunately, very few studies have looked into how probiotic supplementation influences inflammatory skin disorders. The results, though promising, are difficult to implement in clinical practice due to the heterogeneity of the applied supplemental regimen in the different studies. In this Viewpoint, we aim to encourage the conduction of more research in that direction to explore unambiguously the therapeutic potential of oral probiotics in dermatology. We focus on the most common inflammatory skin diseases (atopic dermatitis, psoriasis, rosacea, acne vulgaris) with an associated gut dysbiosis, but we also discuss some less common, but very serious skin pathologies (eg erythema nodosum, pyoderma gangrenosum, hidradenitis suppurativa) that are possibly linked to a disturbed gut flora composition. We dissect the possible mechanisms along the gut-skin axis and highlight novel points where probiotics could interfere in this communication in the diseased state.

scholarly journals The Gut Microbiome: Human Health and Inflammatory Skin Diseases

2020 ◽  
Vol 32 (4) ◽  
pp. 265 ◽  
Author(s):  
Emily A. Mann ◽  
Edward Bae ◽  
Darya Kostyuchek ◽  
Hye Jin Chung ◽  
Jean S. McGee
Keyword(s):  
Human Health ◽  
Gut Microbiome ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin
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