scholarly journals Effects of Topical N-Acetylcysteine on Skin Hydration/Transepidermal Water Loss in Healthy Volunteers and Atopic Dermatitis Patients

2015 ◽  
Vol 27 (4) ◽  
pp. 450 ◽  
Author(s):  
Kozo Nakai ◽  
Kozo Yoneda ◽  
Yumi Murakami ◽  
Ayako Koura ◽  
Reiko Maeda ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Healthy Volunteers ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Skin Hydration

scholarly journals Anti-Atopic Properties of Gracillin Isolated from Dioscorea quinqueloba on 2,4-Dinitrochlorobenzene-Induced Skin Lesions in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1205 ◽  
Author(s):  
Jonghwan Jegal ◽  
No-June Park ◽  
Beom-Geun Jo ◽  
Sim-Kyu Bong ◽  
Hyun Jegal ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Water Loss ◽  
Skin Lesions ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Potential Candidate ◽  
Immunomodulatory Effects ◽  
Hairless Mice ◽  
Naturally Occurring ◽  
Prevention And Treatment

Naturally occurring saponins have been reported to have anti-inflammatory and immunomodulatory effects. However, the effects of gracillin, a main saponin component of Dioscorea quinqueloba (D. quinqueloba), on atopic dermatitis (AD), have not been previously studied. The aim of this study was to determine whether gracillin isolated from D. quinqueloba has an anti-AD effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in SKH-1 hairless mice. Topical co-treatment of gracillin and DNCB for two weeks markedly reduced symptoms typical of AD (redness, itching, swelling and skin lichenification), decreased transepidermal water loss (TEWL) and increased skin hydration. In addition, gracillin strongly inhibited PI-induced IL-4 expression in RBL-2H3 cells and in the skins of AD mice. Our results suggest gracillin is a potential candidate for the prevention and treatment of AD and other inflammatory skin disorders.

The examination of biophysical parameters of skin (transepidermal water loss, skin hydration and pH value) in different body regions of ponies

2012 ◽  
Vol 15 (3) ◽  
pp. 553-559 ◽  
Author(s):  
M.P. Szczepanik ◽  
P.M. Wilkołek ◽  
M. Pluta ◽  
Ł.R. Adamek ◽  
Z.J.H. Pomorski
Keyword(s):  
Water Loss ◽  
Ph Value ◽  
Neck Region ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Lumbar Region ◽  
Biophysical Parameters ◽  
Body Regions ◽  
Skin Ph

Abstract The purpose of this study was to evaluate transepidermal water loss, skin hydration and skin pH in normal ponies. Sixteen ponies of both sexes were examined in the study. Measurements were taken from seven different sites: the neck region, the shoulder, thorax, lumbar, inguinal, lip region and the auricle. In each of the regions transepidermal water loss (TEWL), skin hydration and skin pH were measured. For transepidermal water loss, the lowest values were observed in the lumbar region (9.71g/hm2), while the highest values were observed in the lip region (22.35 g/hm2). In the case of skin hydration the lowest values were observed for the thorax region (2.13 CU), and the highest for the lip region (41.81 CU). For skin pH, the lowest results were obtained in the lumbar region (6.93), and the highest in the lip region (7.96).

scholarly journals Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity

2021 ◽  
Vol 10 (2) ◽  
pp. 359 ◽  
Author(s):  
Trinidad Montero-Vilchez ◽  
María-Victoria Segura-Fernández-Nogueras ◽  
Isabel Pérez-Rodríguez ◽  
Miguel Soler-Gongora ◽  
Antonio Martinez-Lopez ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Severity ◽  
Water Loss ◽  
Barrier Function ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Diagnostic Tools ◽  
Psoriatic Skin ◽  
Skin Barrier Function ◽  
Healthy Controls

Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g·m−2h−1 and temperature > 30.85 °C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) ≥ 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g·m−2 h−1) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 °C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) ≥ 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment.

scholarly journals Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2021
Author(s):  
Aneta Prokopová ◽  
Jana Pavlačková ◽  
Pavel Mokrejš ◽  
Robert Gál
Keyword(s):  
Water Loss ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Elasticity ◽  
Cosmetic Products ◽  
Collagen Hydrolysate ◽  
Carbopol Gel ◽  
Cosmetic Formulation ◽  
The Right ◽  
Positive Effect

Chicken stomachs can be processed into collagen hydrolysate usable in cosmetic products. The aim of the study was to verify the effects of a carbopol gel formulation enriched with 1.0% (w/w) chicken hydrolysate on the properties of the skin in the periorbital area after regular application twice a day for eight weeks in volunteers ageed 50 ± 9 years. Skin hydration, transepidermal water loss (TEWL), skin elasticity and skin relief were evaluated. Overall, skin hydration increased by 11.82% and 9.45%, TEWL decreased by 25.70% and 17.80% (always reported for the right and left area). Generally, there was an increase in skin elasticity, a decrease in skin roughness, as the resonance times decreased by 85%. The average reduction of wrinkles was 35.40% on the right and 41.20% on the left. For all results, it can be seen that the longer the cosmetic gel formulation is applied, the better the results. Due to the positive effect on the quality and functionality of the skin, it is possible to apply the cosmetic gel formulation in the periorbital area. The advantage of the product with chicken collagen hydrolysate is also the biocompatibility with the skin and the biodegradability of the formulation.

scholarly journals Transepidermal Water Loss after Water Immersion

2021 ◽  
Vol 73 (6) ◽  
pp. 386-390
Author(s):  
Rattanavalai Nitiyarom ◽  
Nampen Siriwat ◽  
Wanee Wisuthsarewong
Keyword(s):  
Healthy Volunteers ◽  
Water Loss ◽  
Water Immersion ◽  
Transepidermal Water Loss ◽  
Total Water ◽  
Previous Period ◽  
Cumulative Percentage ◽  
Significant Difference ◽  
Males And Females

Objective: To observe changes in transepidermal water loss (TEWL) at different times after water immersion.Materials and Methods: TEWL values were measured before water immersion and at 3, 5, 10, 15, 20, and 30 minutes after immersion of the skin in water for 5 minutes.Results: Forty-one healthy volunteers were enrolled with an average age of 30.4±5.5 years. Twenty-five subjects were female and sixteen were male. The TEWL value before water immersion (TEWLbaseline) was 13.16±7.27 g/m2/h and TEWL values at 3, 5, 10, 15, 20 and 30 minutes after immersion were 23.21±7.67, 16.12±3.42, 14.76±6.36, 14.45±6.67, 13.53±4.67 and 12.96±5.18 g/m2/h, respectively. After immersion, TEWL values at 3 and 5 minutes statistically increased compared to TEWLbaseline (p<0.001). TEWL values between 10 to 30 minutes gradually dropped with no statistically significant difference compared to the previous period and TEWLbaseline. Although total water loss from the skin occurred within 30 minutes, 56.9% of it occurred within 10 minutes after immersion. There was no significant difference between TEWLbaseline in males and females but the TEWL values at 3, 5 and 15 minutes after immersion in males was higher than in females (p<0.05). Conclusion: TEWL statistically increased after water immersion for only 5 minutes. The cumulative percentage of TEWL was high within 10 minutes. Gender did not affect TEWL values before immersion; however, males experienced more water loss from the skin than females after immersion. Therefore, moisturizer should be applied immediately before TEWL occurs.

scholarly journals Time-of-Day-Dependent Variations of Scratching Behavior and Transepidermal Water Loss in Mice that Developed Atopic Dermatitis

2014 ◽  
Vol 76 (11) ◽  
pp. 1501-1504 ◽  
Author(s):  
Keitaro OHMORI ◽  
Kana MINAMIDE ◽  
Shun GOTO ◽  
Makoto NAGAI ◽  
Junsuke SHIRAI ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Water Loss ◽  
Transepidermal Water Loss ◽  
Time Of Day
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