The Skin Responses to Dimethyl Sulfoxide in Normal Human Forearm Skin

1998 ◽  
Vol 10 (4) ◽  
pp. 233
Author(s):  
Kyung Ywal Lee ◽  
Jun Ha Woo ◽  
Chun Wook Park ◽  
Cheol Heon Lee
Keyword(s):  
Dimethyl Sulfoxide ◽  
Human Forearm ◽  
Forearm Skin ◽  
Normal Human ◽  
Skin Responses

The influence of histamine and PGE2-induced hyperaemia and oedema on respiratory metabolism in normal human forearm skin

1990 ◽  
Vol 29 (3-4) ◽  
pp. 292-298 ◽  
Author(s):  
F. M. T. Carnochan ◽  
N. C. Abbot ◽  
J. S. Beck ◽  
V. A. Spence ◽  
P. B. James
Keyword(s):  
Respiratory Metabolism ◽  
Human Forearm ◽  
Forearm Skin ◽  
Normal Human

Sympathetic sudomotor skin responses induced by laser stimuli in normal human subjects

2002 ◽  
Vol 334 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Alvaro Cervera ◽  
Misericordia Veciana ◽  
Josep Valls-Solé
Keyword(s):  
Human Subjects ◽  
Normal Human ◽  
Skin Responses

Interactions between local and reflex influences on human forearm skin blood flow

1976 ◽  
Vol 41 (6) ◽  
pp. 826-831 ◽  
Author(s):  
J. M. Johnson ◽  
G. L. Brengelmann ◽  
L. B. Rowell
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Forearm Blood Flow ◽  
Lower Body Negative Pressure ◽  
Muscle Blood Flow ◽  
Whole Body ◽  
Vasoconstrictor Response ◽  
Human Forearm ◽  
Forearm Skin ◽  
Forearm Muscle

A three-part experiment was designed to examine interactions between local and reflex influences on forearm skin blood flow (SkBF). In part I locally increasing arm skin temperature (Tsk) to 42.5 degrees C was not associated with increases in underlying forearm muscle blood flow, esophageal temperature (Tes), or forearm blood flow in the contralateral cool arm. In part II whole-body Tsk was held at 38 or 40 degrees C and the surface temperature of one arm held at 38 or 42 degrees C for prolonged periods. SkBF in the heated arm rose rapidly with the elevation in body Tsk and arm Tsk continued to rise as Tes rose. SkBF in the arm kept at 32 degrees C paralleled rising Tes. In six studies, SkBF in the cool arm ultimately converged with SkBF in the heated arm. In eight other studies, heated arm SkBF maintained an offset above cool arm SkBF throughout the period of whole-body heating. In part III, local arm Tsk of 42.5 degrees C did not abolish skin vasoconstrictor response to lower body negative pressure. We conclude that local and reflex influences to skin interact so as to modify the degree but not the pattern of skin vasomotor response.

XVIII Tolerance of the Normal Human Ear to Topical Dimethyl Sulfoxide

1966 ◽  
Vol 75 (1) ◽  
pp. 208-215 ◽  
Author(s):  
Charles P. Lebo ◽  
Paul E. Poenisch ◽  
William S. McAfee
Keyword(s):  
Dimethyl Sulfoxide ◽  
Normal Human ◽  
Human Ear

scholarly journals Small reduction of capsaicin-induced neurogenic inflammation in human forearm skin by the glucocorticoid prednicarbate

1993 ◽  
Vol 38 (S2) ◽  
pp. C31-C34 ◽  
Author(s):  
R. Tafler ◽  
M. K. Herbert ◽  
R. F. Schmidt ◽  
K. H. Weis
Keyword(s):  
Neurogenic Inflammation ◽  
Small Reduction ◽  
Human Forearm ◽  
Forearm Skin

scholarly journals Topically applied methyl nicotinate evokes a temporary inflammation on human skin

2021 ◽  
Vol 18 (1) ◽  
pp. 38-47
Author(s):  
Luis Monteiro Rodrigues ◽  
Sérgio Faloni de Andrade ◽  
Clemente Rocha
Keyword(s):  
Clinical Score ◽  
Transepidermal Water Loss ◽  
Maximal Response ◽  
Methyl Nicotinate ◽  
Skin Reactions ◽  
Doppler Flowmetry ◽  
Institutional Ethics ◽  
Human Models ◽  
Forearm Skin ◽  
Skin Responses

Some challengers such as methylnicotinate (MN) have been used in human models to study the anti-inflammatory effect of topical formulations. However, MN skin responses are still poorly understood and widely varied. In the present study we aim to contribute to better characterise those responses. Eight healthy participants were selected. All procedures were approved by the institutional Ethics Committee. Two aqueous MN dilutions (0.5% and 1.0%) were left in contact for 1 minute in the anterior forearm skin. Following exposure, skin reactions were clinically and biometrically assessed at 30, 60 and 120 minutes and compared with baseline. Measurements involved the ICDRG clinical score scale and select analytical technologies - laser Doppler flowmetry, Polarised Spectroscopy, Transepidermal Water Loss Meter, and High Resolution Sonography. Results have shown that MN application evoked a maximal response at 30 minutes with an increase in the ICDRG score between 1-2. Significant changes in TEWL and microcirculation were observed, as was an increased dermal hypoecogenicity (edema), detected by HRS. These effects are compatible with a localised short-duration inflammation and reinforce the interest of MN to be used as a safe and controllable challenger in human models.

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