scholarly journals Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils

Gut and Liver ◽  
2015 ◽  
Vol 9 (3) ◽  
Author(s):  
Beom Jin Kim ◽  
Jae Yeol Kim ◽  
Eung Soo Hwang ◽  
Jae Gyu Kim
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Nucleotide Binding ◽  
Signal Transducer ◽  
Human Epithelial Cells ◽  
Oligomerization Domain

Effect of Helicobacter pylori on DNA synthesis of human epithelial cells

2005 ◽  
Vol 11 (3) ◽  
pp. 129-135
Author(s):  
Atsushi Toyoda ◽  
Makoto Hasegawa ◽  
Atsushi Toyoda ◽  
Takako Osaki ◽  
Tomoko Hanawa ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Dna Synthesis ◽  
Human Epithelial Cells

S1767 NOD1 is Essential Signal Transducer in Human Gastric Epithelial Cells Infected With Helicobacter pylori

2010 ◽  
Vol 138 (5) ◽  
pp. S-270
Author(s):  
Jae G. Kim ◽  
Beom Jin Kim ◽  
Ki Sung Kim ◽  
Hyoung-Chul Oh ◽  
Jeong Wook Kim
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Signal Transducer ◽  
Gastric Epithelial Cells

scholarly journals Adherent properties of Helicobacter pylori to human epithelial cells

2011 ◽  
Vol 3 (1) ◽  
pp. 35
Author(s):  
Zheng-Xiang Wang ◽  
Hou-Feng Shen ◽  
Hong-Ju Chen
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Human Epithelial Cells

scholarly journals ADP heptose, a novel pathogen-associated molecular pattern associated with Helicobacter pylori type 4 secretion

2018 ◽  
Author(s):  
Lennart Pfannkuch ◽  
Robert Hurwitz ◽  
Jan Traulsen ◽  
Paul Kosma ◽  
Monika Schmid ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Gram Negative Bacteria ◽  
Gene Encoding ◽  
Gram Negative ◽  
Human Epithelial Cells ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern ◽  
Encoding Gene ◽  
H Pylori

AbstractThe gastric pathogen Helicobacter pylori activates the NF-κB pathway in human epithelial cells via the α-kinase 1 (Alpk1)–TIFA axis. We and others have previously shown that heptose 1,7-bisphosphate (HBP) acts as a pathogen-associated molecular pattern (PAMP). HBP is an intermediate of lipopolysaccharide (LPS) synthesis in H. pylori and other gram-negative bacteria. Deletion of the hldE (rfaE) gene encoding the enzyme responsible for HBP synthesis, as well as deletion of further upstream genes, causes loss of NF-κB stimulation by H. pylori, while deletion of the downstream phosphatase encoding gene gmhB does not. This has led to the conclusion that HBP is the PAMP responsible for NF-κB induction. Here, our attempts to identify HBP in lysates of H. pylori revealed surprisingly low amounts that fail to explain NF-κB activation. Instead, we identified ADP heptose, a major downstream metabolite of HdlE, as the predominant PAMP in H. pylori lysates, exhibiting ∼100-fold stronger activity compared to HBP. It therefore appears that synthesis of ADP heptose from HBP in H. pylori occurs independently of GmhB. The data lead us to conclude that ADP heptose constitutes the key PAMP, secreted via the pathogen’s cagPAI encoded type 4 secretion (T4SS).

scholarly journals Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells

2010 ◽  
Vol 93 (10) ◽  
pp. 4526-4534 ◽  
Author(s):  
Y. Shirasawa ◽  
H. Shibahara-Sone ◽  
T. Iino ◽  
F. Ishikawa
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Bifidobacterium Bifidum ◽  
Human Epithelial Cells ◽  
Induced Genes

T1810 NOD1 Upregulate Expression of IL-8 Through NF-κB Activation in Human Epithelial Cells Infected with Helicobacter pylori

2008 ◽  
Vol 134 (4) ◽  
pp. A-568
Author(s):  
Jae G. Kim ◽  
Bum Joon Park ◽  
Su Yeon Rhie ◽  
Ki Sung Kim ◽  
Sill Moo Park
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Human Epithelial Cells

Colostrum IgA1 antibodies recognize antigens from Helicobacter pylori and prevent cytoskeletal changes in human epithelial cells

2021 ◽  
Author(s):  
Shantal Lizbeth Baltierra‐Uribe ◽  
Alejandra Montañez‐Barragán ◽  
Héctor Romero‐Ramírez ◽  
Ksenia Klimov‐Kravtchenko ◽  
Karla Ivette Martínez‐Pedro ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Human Epithelial Cells

The impact of the nucleotide-binding oligomerization domain 1 (NOD 1) gene polymorphism on Helicobacter Pylori induced chronic gastritis in hepatic patients.

2021 ◽  
Vol 30 (3) ◽  
pp. 9-19
Author(s):  
Enas M. Ghoneim ◽  
Eman H. Hassan ◽  
Hassan Zaghla ◽  
Doha Taie ◽  
Samah M. Awad
Keyword(s):  
Helicobacter Pylori ◽  
Gene Polymorphism ◽  
Chronic Gastritis ◽  
Nucleotide Binding ◽  
Esophageal Hiatus ◽  
Rapid Urease Test ◽  
Tissue Samples ◽  
Urease Test ◽  
The Impact ◽  
Oligomerization Domain

Background: Chronic infection with Helicobacter pylori (H.pylori ) causes atrophic and even gastric metaplastic changes, and it has a well-known link to peptic ulceration. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that is presented by the NOD1 gene. It distinguishes H.pylori bacterial molecules and enhances an immune response Objectives: to describe the relation between the NOD1 gene (rs2075820) polymorphism and H.pylori infection in hepatic and non hepatic patients with chronic gastritis, study its impact on the degree of chronic gastritis in H.pylori positive individuals, and to examine the effect of H. pylori on clinical, endoscopic and histopathological findings and child paugh scoring in hepatic patients. Methodology: Gastric tissue samples were taken from selected 200 patients with chronic gastritis, either hepatic or non hepatic. Rapid urease test and pathological findings classified them into H.pylori infected and non infected patients. Genotyping of NOD 1 was studied using polymerase chain reaction /restriction fragment length polymorphism (PCR–RFLP) method. Results: A significant higher frequency of AA genotype, and the A allele of NOD1 gene in H.pylori +ve patients, either hepatic; (58%)-(73%) or non hepatic;(62%)-(78%) as compared to H.pylori –ve patients,(P <0.001). A highly significant relation between NOD1 genotypes and endoscopic findings, where most of H.pylori infected patients with AA genotype had more peptic ulcer, antral erosion, gastric prolapse, esophageal varices and esophageal hiatus hernia compared to patients with GA and GG genotypes, (P<0.001). No significant impact of H.pylori on signs of liver affection and child paugh scoring in hepatic patients. Conclusions: In NOD1 gene polymorphism, AA genotype and A allele have significantly implicated in H.pylori infection susceptibility and progression. While GG genotype and G allele have a protective effect against H.pylori infection.

scholarly journals MyD88 and TNF Receptor-Associated Factor 6 Are Critical Signal Transducers in Helicobacter pylori-Infected Human Epithelial Cells

2006 ◽  
Vol 176 (6) ◽  
pp. 3796-3803 ◽  
Author(s):  
Yoshihiro Hirata ◽  
Tomoya Ohmae ◽  
Wataru Shibata ◽  
Shin Maeda ◽  
Keiji Ogura ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Tnf Receptor ◽  
Critical Signal ◽  
Associated Factor ◽  
Signal Transducers ◽  
Human Epithelial Cells
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