Colostrum IgA1 antibodies recognize antigens from Helicobacter pylori and prevent cytoskeletal changes in human epithelial cells

2021 ◽  
Author(s):  
Shantal Lizbeth Baltierra‐Uribe ◽  
Alejandra Montañez‐Barragán ◽  
Héctor Romero‐Ramírez ◽  
Ksenia Klimov‐Kravtchenko ◽  
Karla Ivette Martínez‐Pedro ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Human Epithelial Cells

Effect of Helicobacter pylori on DNA synthesis of human epithelial cells

2005 ◽  
Vol 11 (3) ◽  
pp. 129-135
Author(s):  
Atsushi Toyoda ◽  
Makoto Hasegawa ◽  
Atsushi Toyoda ◽  
Takako Osaki ◽  
Tomoko Hanawa ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Dna Synthesis ◽  
Human Epithelial Cells

scholarly journals Adherent properties of Helicobacter pylori to human epithelial cells

2011 ◽  
Vol 3 (1) ◽  
pp. 35
Author(s):  
Zheng-Xiang Wang ◽  
Hou-Feng Shen ◽  
Hong-Ju Chen
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Human Epithelial Cells

scholarly journals ADP heptose, a novel pathogen-associated molecular pattern associated with Helicobacter pylori type 4 secretion

2018 ◽  
Author(s):  
Lennart Pfannkuch ◽  
Robert Hurwitz ◽  
Jan Traulsen ◽  
Paul Kosma ◽  
Monika Schmid ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Gram Negative Bacteria ◽  
Gene Encoding ◽  
Gram Negative ◽  
Human Epithelial Cells ◽  
Molecular Pattern ◽  
Pathogen Associated Molecular Pattern ◽  
Encoding Gene ◽  
H Pylori

AbstractThe gastric pathogen Helicobacter pylori activates the NF-κB pathway in human epithelial cells via the α-kinase 1 (Alpk1)–TIFA axis. We and others have previously shown that heptose 1,7-bisphosphate (HBP) acts as a pathogen-associated molecular pattern (PAMP). HBP is an intermediate of lipopolysaccharide (LPS) synthesis in H. pylori and other gram-negative bacteria. Deletion of the hldE (rfaE) gene encoding the enzyme responsible for HBP synthesis, as well as deletion of further upstream genes, causes loss of NF-κB stimulation by H. pylori, while deletion of the downstream phosphatase encoding gene gmhB does not. This has led to the conclusion that HBP is the PAMP responsible for NF-κB induction. Here, our attempts to identify HBP in lysates of H. pylori revealed surprisingly low amounts that fail to explain NF-κB activation. Instead, we identified ADP heptose, a major downstream metabolite of HdlE, as the predominant PAMP in H. pylori lysates, exhibiting ∼100-fold stronger activity compared to HBP. It therefore appears that synthesis of ADP heptose from HBP in H. pylori occurs independently of GmhB. The data lead us to conclude that ADP heptose constitutes the key PAMP, secreted via the pathogen’s cagPAI encoded type 4 secretion (T4SS).

scholarly journals Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells

2010 ◽  
Vol 93 (10) ◽  
pp. 4526-4534 ◽  
Author(s):  
Y. Shirasawa ◽  
H. Shibahara-Sone ◽  
T. Iino ◽  
F. Ishikawa
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Bifidobacterium Bifidum ◽  
Human Epithelial Cells ◽  
Induced Genes

T1810 NOD1 Upregulate Expression of IL-8 Through NF-κB Activation in Human Epithelial Cells Infected with Helicobacter pylori

2008 ◽  
Vol 134 (4) ◽  
pp. A-568
Author(s):  
Jae G. Kim ◽  
Bum Joon Park ◽  
Su Yeon Rhie ◽  
Ki Sung Kim ◽  
Sill Moo Park
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Human Epithelial Cells

scholarly journals MyD88 and TNF Receptor-Associated Factor 6 Are Critical Signal Transducers in Helicobacter pylori-Infected Human Epithelial Cells

2006 ◽  
Vol 176 (6) ◽  
pp. 3796-3803 ◽  
Author(s):  
Yoshihiro Hirata ◽  
Tomoya Ohmae ◽  
Wataru Shibata ◽  
Shin Maeda ◽  
Keiji Ogura ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Tnf Receptor ◽  
Critical Signal ◽  
Associated Factor ◽  
Signal Transducers ◽  
Human Epithelial Cells
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