scholarly journals Effect of EPA and Vitamin C on Superoxide Dismutase, Glutathione Peroxidase, Total Antioxidant Capacity and Malondialdehyde in Type 2 Diabetic Patients

2014 ◽  
Vol 29 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Mohammad Mehdi Shakouri Mahmoudabadi ◽  
Ali Reza Rahbar
Keyword(s):  
Superoxide Dismutase ◽  
Vitamin C ◽  
Glutathione Peroxidase ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Total Antioxidant ◽  
Type 2 Diabetic

scholarly journals The Association of Antioxidant Status of Red Blood Cells in Patients with Type 2 Diabetes and in Patients with Complications of Diabetes and Its Comparison with That of Healthy Subjects

2021 ◽  
Vol 10 (11) ◽  
pp. 825-828
Author(s):  
Chethan Subramanya
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Superoxide Dismutase ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Type 2 Diabetics ◽  
Total Antioxidant

BACKGROUND Oxidative stress plays a role in the pathogenesis of type 2 diabetes either by affecting insulin secretion or increasing insulin resistance. Oxidative stress is dealt by the body with the help of several antioxidant systems. The antioxidant levels in disorders causing oxidative stress such as diabetes mellitus are found to be low. Total antioxidant capacity (TAC), superoxide dismutase (SOD) and glutathione peroxide (GPx) levels are found to be depleted in diabetic groups when compared to control group comprising of healthy individuals. The activities of SOD and GPx are significantly low in diabetic patients. This study was conducted to determine the total antioxidant capacity and levels of antioxidants such as SOD and GPx in patients with type 2 diabetes and association between antioxidant levels and type 2 diabetics as well as type 2 diabetes with its associated complications. METHODS The study population comprised of 150 individuals, 50 subjects belonging to each subgroup of type 2 diabetics, and its associated complications and healthy subjects. The study was conducted in a tertiary care centre in Mangalore, Karnataka from September 2016 to December 2016. The antioxidant capacity of RBC, fasting blood levels of SOD and GPx were estimated by phospho molybdenum method. Nitroblue tetrazolium (NBT) reduction method and Rotruck method were also used. RESULTS The total antioxidant capacity, SOD and GPx were lower among diabetics and diabetic patients with complications as compared to normal nondiabetic subjects. CONCLUSIONS There is no significant difference in oxidative stress between patients with and without chronic complications of diabetes. KEY WORDS Antioxidant Levels, Glutathione Peroxidase, Oxidative Stress, Superoxide Dismutase, Nitroblue tetrazolium Reduction

Effect of Vitamin C Supplementation on Postprandial Oxidative Stress and Lipid Profile in Type 2 Diabetic Patients

2011 ◽  
Vol 14 (19) ◽  
pp. 900-904 ◽  
Author(s):  
Zohreh Mazloom ◽  
Najmeh Hejazi ◽  
Mohammad-Hossein Dabbaghman ◽  
Hamid-Reza Tabatabaei ◽  
Afsane Ahmadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Vitamin C Supplementation ◽  
Type 2 Diabetic

scholarly journals Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients

2004 ◽  
Vol 181 (3) ◽  
pp. 413-417 ◽  
Author(s):  
T Adachi ◽  
M Inoue ◽  
H Hara ◽  
E Maehata ◽  
S Suzuki
Keyword(s):  
Insulin Resistance ◽  
Superoxide Dismutase ◽  
Plasma Levels ◽  
Tnf Alpha ◽  
Diabetic Patients ◽  
Extracellular Superoxide Dismutase ◽  
Type 2 Diabetic Patients ◽  
Relationship Of ◽  
Type 2 Diabetic

Extracellular-superoxide dismutase (EC-SOD) is a secretory glycoprotein located in blood vessel walls at high levels and may be important in the antioxidant capability of vascular walls. The aim of this study was to assess plasma levels of EC-SOD and to evaluate the relationship of the EC-SOD level with insulin resistance in type 2 diabetic patients. We determined plasma EC-SOD in 122 patients and found for the first time that the EC-SOD level was strongly and positively related to adiponectin (r=0.503, P < 0.001), and significantly and inversely related to fasting plasma glucose (FPG) (r=-0.209, P=0.022), body-mass index (BMI) (r=-0.187, P=0.040) and homeostasis model assessment-insulin resistance index (HOMA-R) (r=-0.190, P=0.039). Stepwise-multiple regression analysis also showed a significant influence of adiponectin (F=33.27) on the EC-SOD level. Administration of pioglitazone to 19 diabetic patients significantly increased the plasma levels of EC-SOD (69.9+/-19.3 ng/ml to 97.4+/-25.9 ng/ml; P < 0.0001) and adiponectin, while it decreased tumor necrosis factor-alpha (TNF-alpha). The present observations suggest that factors related to the pathogenesis of insulin resistance play an important role in the regulation of the plasma EC-SOD concentration. It is possible that the increase in the EC-SOD level by pioglitazone administration in diabetic patients is due to a decline of TNF-alpha, which is known to suppress EC-SOD expression.

scholarly journals Malondialdehyde, glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria

2005 ◽  
Vol 42 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Gülsen Ozdemır ◽  
Meltem Ozden ◽  
Hale Maral ◽  
Sevinc Kuskay ◽  
Pinar Cetınalp ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Vascular Disease ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Total Homocysteine ◽  
Type 2 Diabetic

Background: High levels of homocysteine and oxidative stress are known to be associated with premature vascular disease in type 2 diabetes mellitus (DM). The aim of this study was to estimate homocysteine levels and oxidant-antioxidant status and to determine the relationship between them in type 2 diabetic patients with and without microalbuminuria. Methods: Fasting blood samples were obtained from 48 diabetic patients (17 with and 31 without microalbuminuria) and 20 healthy subjects. Serum total homocysteine (tHcy), plasma malondialdehyde (MDA) erythrocyte glutathione (GSH) and glutathione peroxidase (GPx) activity were measured in these patients and the results were compared with those of controls who were chosen among healthy subjects. Results: MDA levels were found to be significantly lower and GSH levels and GPx activities were found to be significantly higher in control subjects when compared with patients with and without microalbuminuria (MDA: P<0.0001, P<0.0001; GSH: P<0.0001, P<0.0001; GPx: P<0.0001, P<0.001, respectively). MDA levels were found to be significantly higher in patients with microalbuminuria compared with patients without microalbuminuria ( P<0.0001), while similarly GSH levels were found to be significantly lower in patients with microalbuminuria ( P<0.0001). Although there were no significant differences with respect to tHcy levels and GPx activities between the microalbuminuric and normoalbuminuric patients ( P>0.05), there was a significant difference with respect to tHcy levels between healthy controls and patients with microalbuminuria ( P<0.05). The serum levels of tHcy correlated best with plasma MDA and erythrocyte GSH concentrations in all diabetic patients ( r=0.549, P<0.0001; r=0.385, P<0.01). Conclusion: Decreased antioxidant levels, increased lipid peroxidation and increased tHcy levels were observed in patients with microalbuminuria. These changes may contribute to vascular disease, which is particularly prevalent in type 2 DM patients with microalbuminuria.

scholarly journals Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Essam Eldin Mohamed Nour Eldin ◽  
Abdullah Almarzouki ◽  
Adel Mohamed Assiri ◽  
Osman Mohammed Elsheikh ◽  
Badreldin Elsonni Abdalla Mohamed ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Total Antioxidant ◽  
Type 2 Diabetic

scholarly journals Leukocyte Lipid Peroxidation, Superoxide Dismutase and Catalase Activities of Type 2 Diabetic Patients with Retinopathy

2005 ◽  
Vol 48 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Naciye Kurtul ◽  
Ebubekir Bakan ◽  
Hülya Aksoy ◽  
Orhan Baykal
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Type 2 Diabetic ◽  
Type 2 Diabetic Retinopathy

Increased oxidative stress might play an important role in the initiation and progression of diabetic complications. The present study has been undertaken to investigate whether there is any relationship between retinopathy degree and leukocyte superoxide dismutase (SOD) and catalase (CAT) activities and lipid peroxidation (LPO) in diabetic individuals with type 2 diabetic retinopathy. Patients were groupped with respect to the degree of retinopathy. Leukocyte malondialdehyde (MDA) levels, and SOD and CAT activities were measured in patients with type 2 diabetes mellitus (n=41) and nondiabetic healthy controls (n=23). Leukocyte LPO of the type 2 diabetic patients with retinopathy was significantly increased (p< 0.001), whereas SOD and CAT activities were decreased (p<0.001 and p<0.001, respectively) compared to those of controls. MDA concentrations rose while SOD and CAT activities fell with increasing severity of diabetic retinopathy, altough there was no significant difference in comprasion of the parameters mentioned above between the diabetic patients with and without retinopathy. Our results show that leukocytes in patients with type 2 diabetic retinopathy are affected by oxidative stress which might be contribute to pathogenesis of diabetic retinopathy. Prospective studies are needed to evaulate the relationship between the leukocyte antioxidants status and DR.

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