scholarly journals Extradural Hemorrhage: A rare Complication and Manifestation of Stroke in Sickle Cell Disease

2010 ◽  
Author(s):  
Muhammad J. Azhar
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Rare Complication ◽  
Cell Disease

Cranial epidural hematomas: A case series and literature review of this rare complication associated with sickle cell disease

2016 ◽  
Vol 64 (3) ◽  
pp. e26237 ◽  
Author(s):  
Jennifer Hamm ◽  
Nisha Rathore ◽  
Pearlene Lee ◽  
Zachary LeBlanc ◽  
Jeffrey Lebensburger ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Literature Review ◽  
Sickle Cell ◽  
Rare Complication ◽  
Case Series ◽  
Cell Disease

Acute Hepatic Sequestration Crisis: A Rare Complication of Sickle Cell Disease

2010 ◽  
Vol 105 ◽  
pp. S289-S290
Author(s):  
Bradford Whitmer ◽  
Fernando Gamarra ◽  
Laurence Stawick
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Rare Complication ◽  
Cell Disease

scholarly journals Clinical and laboratory parameters, risk factors predisposing to the development of priapism in sickle cell patients

2019 ◽  
Vol 245 (1) ◽  
pp. 79-83
Author(s):  
Salam Alkindi ◽  
Said S Almufargi ◽  
Anil Pathare
Keyword(s):  
Risk Factors ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cardiovascular Response ◽  
Rare Complication ◽  
Acute Chest Syndrome ◽  
Mean Corpuscular Hemoglobin ◽  
Cell Disease ◽  
Laboratory Parameters ◽  
Blood Exchange

Although sickle cell disease is very common in Oman, priapism is a relatively rare complication of this disease. This study was aimed to identify the clinical and laboratory risk factors that predispose sickle cell disease patients to priapism. In a retrospective, case-control study, data on 21 male sickle cell disease patients, with priapism, were compared to 20 age and sex-matched sickle cell disease patients without priapism from the hospital medical records. Specifically, the demographical, hematological, biochemical, and clinical parameters including complications attributable to priapism were studied. Means for continuous measures and independent t-test were used to evaluate the association between the parameter studied and the occurrence of priapism. Priapism occurrence was associated with low basal hemoglobin (Hb), along with an increase in other parameters such as white blood cell count (WBC) ( P = 0.010), platelet count ( P = 0.001), reticulocyte count ( P < 0.001), mean corpuscular volume (MCV) ( P < 0.001), and mean corpuscular hemoglobin (MCH) ( P < 0.001). Biochemical laboratory parameters revealed an association with an increased total bilirubin ( P < 0.001). Patients with priapism were more likely to have acute chest syndrome, stroke, pulmonary hypertension, asplenia ( P = 0.006), gallbladder stones, and consequently cholecystectomy. Blood exchange and Penile aspiration were the most frequent medical therapies ( P = 0.010 and P < 0.001 respectively). Patients with sickle cell disease who presented with priapism were young adults with low Hb, high WBC’s, platelets, reticulocytes, MCV, MCH, bilirubin, and LDH. These findings suggest an association of priapism with increased hemolysis. Impact statement Sickle cell disease is prevalent throughout the world with a 5.8% incidence of sickle cell trait among the Omani population, yet priapism was a relatively rare complication. Penile erection and detumescence are complex physiological processes, which require a delicate neurohormonal and cardiovascular response. In this cohort, young SCD patients developed priapism with a low incidence of complications. These patients had high WBCs, platelets, bilirubin, LDH, and reticulocytes with low hemoglobin as compared to controls, suggesting an increased hemolytic process. Favorable outcome was dependent on early intervention, with almost half of these patients needing surgical intervention.

scholarly journals Major Artery Occlusion: a Rare Complication of Sickle Cell Disease

1970 ◽  
Vol 2 (1) ◽  
pp. e2010007
Author(s):  
Adnan Agha
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Internal Carotid ◽  
Rare Complication ◽  
Artery Occlusion ◽  
Left Internal Carotid Artery ◽  
Cell Disease ◽  
Vessel Occlusion ◽  
Major Vessel ◽  
Haemolytic Anemia

Abstract: Sickle cell disease is hereditary hemoglobinopathy which causes haemolytic anemia, vaso-occlusive crisis, ischemic injuries and many other morbidities like cerebral infarction.  In this report, we describe a case of a young patient with sickle cell disease presenting with right-sided weakness and slurring of speech with examination confirming right-sided hemiparesis with motor aphasia. On further investigation, she was found to have frontotemporal infarction.  On magnetic resonance imaging with angiography, she was found to have absent circulation in left internal carotid artery probably secondary to sickle cell disease.  Major vessel occlusion is rare complication of sickle cell disease that one must bear in mind.

scholarly journals Acute compartment syndrome in a patient with sickle cell disease

2020 ◽  
Vol 102 (9) ◽  
pp. e1-e2
Author(s):  
E Cochrane ◽  
S Young ◽  
Z Shariff
Keyword(s):  
Sickle Cell Disease ◽  
Compartment Syndrome ◽  
Sickle Cell ◽  
Rare Complication ◽  
The United States ◽  
Acute Compartment Syndrome ◽  
Acute Chest Syndrome ◽  
Cell Disease ◽  
The United Kingdom ◽  
Considerable Morbidity

Haemoglobin SC (HbSC) disease accounts for 30% of cases of sickle cell disease in the United Kingdom and the United States. Unlike other sickle cell carriers, who are relatively asymptomatic, people with HbSC disease have a combination of genotypes with the potential to cause considerable morbidity due to intracellular water loss. Patients can present with acute pain, acute chest syndrome, proliferative retinopathy, splenic and renal complications, or stroke. We present a young man with HbSC disease who developed acute compartment syndrome. This is only the second report of this syndrome in a patient with HbSC disease. This is a very rare complication in HbSC disease, but it can have serious implications.

scholarly journals Orbital compression syndrome: a rare complication of sickle cell disease in children

2019 ◽  
Vol 6 (2) ◽  
pp. 890
Author(s):  
Prateek Kumar Panda ◽  
Srikant Kumar Padhy
Keyword(s):  
Sickle Cell Disease ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Surgical Intervention ◽  
Rare Complication ◽  
Red Blood Cell Transfusion ◽  
Uneventful Recovery ◽  
Cell Disease ◽  
Compression Syndrome

Vasoocclusive crises in sickle cell disease commonly involve bone marrow of the long bones and vertebrae. Involvement of bones with less marrow space, including the bones of the orbit, is reported rarely in the literature. The present case is a 6-year-old boy, a known case of sickle cell disease, who presented with acute onset right upper and lower eyelid swelling, restriction of extraocular movement and pain. USG orbit showed a retroorbital hemorrhage compressing on the orbit, probably due to orbital bone infarction. The child was managed successfully with red blood cell transfusion and intravenous antibiotics, without steroids and surgical intervention. This report highlights the importance of maintaining a high index of suspicion in patients with known sickle cell disease presenting with pain, orbital swelling and restriction of ocular movement. Timely red blood cell transfusion only may be sufficient for uneventful recovery, without steroids or surgical intervention. Expedient diagnosis of orbital compression syndrome in children with sickle cell disease is crucial because this is a potentially sight-threatening entity.

scholarly journals Spontaneous Epidural Hemorrhage in Sickle Cell Disease, Are They All the Same? A Case Report and Comprehensive Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Biplab Saha ◽  
Aditi Saha
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
World Literature ◽  
Rare Complication ◽  
Middle Meningeal Artery ◽  
African American Female ◽  
Rare Entity ◽  
Cell Disease ◽  
Common Causes ◽  
Epidural Hemorrhage

Trauma to the skull causing injury to the middle meningeal artery, middle meningeal vein, or dural venous sinuses is responsible for most cases of epidural hemorrhage (EDH). Spontaneous EDH is a rare entity in clinical practice. Common causes include sinusitis, coagulation abnormalities, dural metastasis, and Langerhans cell histiocytosis. Isolated nontraumatic EDH is an exceedingly rare complication of sickle cell disease (SCD). We report a case of spontaneous EDH in a patient with SCD and review the world literature regarding this rare entity. A 20-year-old African American female with sickle cell disease presented with vaso-occlusive crisis. About 24 hours after hospital admission, the patient had sudden deterioration of her mental status. An emergent CT scan of the head revealed a large right-sided frontoparietal epidural hematoma with midline shift, subfalcine, and uncal herniation. The patient underwent emergent hematoma evacuation but died 24 hours after surgery.

Sign in / Sign up

Export Citation Format

Share Document