scholarly journals SOFT TISSUE EPITHELIOID VASCULAR TUMORS: A PRACTICAL CLINICO PATHOLOGICAL DIAGNOSTIC APPROACH

2021 ◽  
Vol 01 (04) ◽  
pp. 242
Author(s):  
C. Gerosa ◽  
D. Fanni ◽  
E. Massa ◽  
E. Lai ◽  
A. Ravarino ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Diagnostic Approach ◽  
Vascular Tumors

Soft tissue vascular tumors. A flow cytometric DNA analysis

Cancer ◽  
1993 ◽  
Vol 71 (7) ◽  
pp. 2233-2241 ◽  
Author(s):  
Masaharu Fukunaga ◽  
Tadakazu Shimoda ◽  
Takashi Nikaido ◽  
Shinichiro Ushigome ◽  
Eisei Ishikawa
Keyword(s):  
Soft Tissue ◽  
Dna Analysis ◽  
Vascular Tumors ◽  
Flow Cytometric

scholarly journals Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

2021 ◽  
Vol 9 (11) ◽  
pp. 3391
Author(s):  
Khadija S. Tapadar ◽  
Manoj K. Deka ◽  
R. N. Chaubey ◽  
Shah A. Sheikh ◽  
Gargi R. Choudhury ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
The Body ◽  
World Health ◽  
Vascular Tumors ◽  
Benign Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Pleomorphic Sarcoma ◽  
Younger Age

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and   lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

Vascular tumors of bone and soft tissue

2013 ◽  
pp. 165-182
Author(s):  
Lester J. Layfield ◽  
Carlos W. Bedrossian ◽  
Julia R. Crim ◽  
Lucio Palombini
Keyword(s):  
Soft Tissue ◽  
Vascular Tumors ◽  
Tumors Of Bone

scholarly journals Sinonasal Hemangiopericytomas: Clinicopathologic and Imaging Findings

2005 ◽  
Vol 84 (2) ◽  
pp. 99-102 ◽  
Author(s):  
Enrique Palacios ◽  
Santiago Restrepo ◽  
Luciano Mastrogiovanni ◽  
Giovanni D. Lorusso ◽  
Rafael Rojas
Keyword(s):  
Soft Tissue ◽  
Retrospective Review ◽  
Soft Tissue Sarcomas ◽  
The Body ◽  
Vascular Tumors ◽  
Imaging Findings ◽  
Mesenchymal Tumors ◽  
Imaging Characteristics ◽  
Neoplastic Lesions ◽  
Pathologic Findings

Hemangiopericytomas are rare soft-tissue neoplastic lesions that can arise in any part of the body. They are mesenchymal tumors that account for 3 to 5% of all soft-tissue sarcomas and 1% of all vascular tumors. They originate in extravascular cells (pericytes). Some 15 to 30% of all hemangiopericytomas occur in the head and neck; of these, approximately 5% occur in the sinonasal area. We describe our brief retrospective review of 7 histologically proven cases of sinonasal hemangiopericytoma, and we discuss the imaging characteristics and clinical and pathologic findings in these patients.

A phase II study of aflibercept (VEGF trap) in recurrent or metastatic gynecologic soft-tissue sarcomas: A study of the Princess Margaret Hospital Phase II Consortium

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 5591-5591
Author(s):  
C. Townsley ◽  
H. Hirte ◽  
P. Hoskins ◽  
R. Buckanovich ◽  
H. Mackay ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Adverse Events ◽  
Phase Ii ◽  
Stable Disease ◽  
Soft Tissue Sarcomas ◽  
Vascular Tumors ◽  
Open Label ◽  
Grade 3 ◽  
Long Acting ◽  
Vegf Trap

5591 Background: Targeting angiogenesis and vascular endothelial growth factor (VEGF) represents a promising approach to treat highly vascular tumors, like gynecologic sarcomas. Aflibercept, a long-acting inhibitor of VEGF signaling, potently binds and inactivates VEGF, thus blocking tumor angiogenesis and growth. Methods: This is a single-arm, open-label, two-stage phase II clinical trial designed to evaluate the efficacy and toxicity of aflibercept as treatment for patients (pts) with recurrent, or metastatic gynecologic soft tissue sarcoma. Aflibercept was administered at 4 mg/kg IV every 2 weeks and pts had radiologic imaging performed every 8 weeks. The primary endpoints were response rate and prolonged stable disease. Results: Twenty-five pts with leiomyosarcoma of the uterus and 13 pts with carcinosarcoma of the uterus were enrolled in 2 cohorts. In the leiomyosarcoma group, 24/25 pts had an ECOG of <1, most pts (22/25) had <1 previous lines of treatment and 7/25 pts had prior radiotherapy. A total of 149 cycles were administered for this group, with a median of 4 (range 2–28). In the carcinosarcoma group, 10/13 pts had an ECOG of <1, most pts (12/13) had <1 previous lines of treatment and 5/13 pts had prior radiotherapy. A total of 31 cycles were administered with a median of 3 (range 1–4). The most frequent adverse events experienced by all pts, of any grade, were fatigue 71% pts, constipation 53% and hypertension 39% . The most frequent grade 3 or higher, adverse events were hypertension 18%, fatigue 13% and lymphopenia 8%. Eight pts with leiomyosarcoma had stable disease (4pts > 6 mo). No reponses were seen in either cohort and no stable disease was seen in the carcinosarcoma group. Median overall survival was 15.1 mo (95% CI: 8.5 - not reached) for the leiomyosarcoma cohort and 3.1 mo for the carcinosarcoma cohort (95% CI: 1.9 - not reached). The requirements to proceed to stage 2, in leiomyosarcoma, were met after more than 2/21 patients had > 6 mo PFS. Carcinosarcoma cohort has not finished stage 1 and both cohorts continue accrual. Conclusions: VEGF-trap was well tolerated in this pt population with acceptable side effects. Initial efficacy data suggests modest activity, particularly in patients with leiomyosarcoma. [Table: see text]

scholarly journals Giant glomus tumor of the knee mimicking soft-tissue sarcoma

2020 ◽  
Vol 2 ◽  
pp. 82-86
Author(s):  
Vikas Batra ◽  
Nafisa Shakir Batta ◽  
Ankur Gupta
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Unusual Case ◽  
Glomus Tumor ◽  
Biceps Femoris ◽  
Soft Tissue Tumors ◽  
Vascular Tumors ◽  
Glomus Tumors ◽  
Posterior Knee ◽  
Point Tenderness

Glomangiomas (glomus tumors) are benign vascular tumors commonly located at the distal extremities, are usually subungual lesions, and account for 2% of all soft-tissue tumors. Patients with digital glomus tumors present with hypersensitivity to cold, paroxysmal severe pain, and point tenderness. These tumors are infrequent in the knee area, and when seen are superficial, usually have a diameter of less than 1 cm, which make their radiological diagnosis arduous. We report a noteworthy, unusual case of a large glomus tumor in the popliteal fossa showing biceps femoris infiltration, in a 51-year-old female patient who experienced severe intermittent posterior knee pain for the past 2 years. Magnetic resonance imaging revealed a large popliteal inhomogeneous soft-tissue lesion with irregular margins insinuating the posterolateral musculature mimicking soft-tissue sarcoma. Histopathology revealed a glomus tumor.

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