scholarly journals Development and Computerized Implementation of an Impaired Driving Intervention for College Students

2020 ◽  
Vol 29 (2) ◽  
Author(s):  
Ryan Martin ◽  
Stuart Usdan ◽  
Jennifer Cremeens ◽  
Randy Devereaux ◽  
Supriya Reddy ◽  
...  
Keyword(s):  
College Students ◽  
Pilot Test ◽  
Positive Outcomes ◽  
Drinking And Driving ◽  
Excessive Alcohol Consumption ◽  
Impaired Driving ◽  
Health Concerns ◽  
Excessive Alcohol ◽  
Participant Screening ◽  
Program Components

Excessive alcohol consumption and drinking and driving among college students are public health concerns. Online alcohol-related interventions have produced some positive outcomes in the college student populations; however, online interventions to reduce drinking and driving specifically have been neither developed nor tested. We developed an online Impaired Driving Intervention (IDI) using the Impaired Driving Assessment, a modified alcohol-specific version of timeline follow-back method of assessing behavior. This research examines: (1) the development of the IDI; (2) a pilot test of the IDI among 19 undergraduates; and (3) the refinements made to the program based on the pilot test. As a result of our pilot test, we changed the timing of our participant screening and for several program components we provided clearer instructions, including the addition of informative “pop-up” windows.

Preventing High-Risk Drinking among College Students: A Social Marketing Case Study

2010 ◽  
Vol 16 (4) ◽  
pp. 92-110 ◽  
Author(s):  
Tavis J. Glassman ◽  
Virginia Dodd ◽  
Eleanor Maureen Miller ◽  
Robert E. Braun
Keyword(s):  
College Students ◽  
Emergency Department ◽  
High Risk ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Social Marketing ◽  
Drinking And Driving ◽  
The Social ◽  
Excessive Alcohol ◽  
High Risk Drinking

Investigators implemented a social marketing intervention to reduce alcohol consumption at a large university in the southeastern United States. The objective was to decrease high-risk drinking and drinking and driving and to change the perception that alcohol use increases sexual opportunities among college students. Formative research revealed that high-risk college students associate undesirable social consequences with excessive drinking (e.g., embarrassing oneself, annoying peers, offending the other sex, or burdening friends). An intervention was developed in which the product was avoiding the social stigma associated with excessive alcohol consumption. Promotional materials illustrating the social repercussions associated with excessive alcohol use and promoting the advantages of moderating one's drinking were disseminated in popular student venues; price was raised by increased law enforcement; and place was addressed by providing alcohol-free alternative activities. Evaluation included a time-series design in which students completed an anonymous online standard alcohol and drug survey and reviewing campus records of drinking under the influence (DUI) citations, alcohol-related judicial violations, and emergency department transports for alcohol overdose. Self-reported high-risk drinking, drinking and driving, and the perception that alcohol facilitates sexual opportunity rates decreased 33%, 45%, and 21%, respectively. DUI violations, alcohol-related judicial violations, and student transports to the emergency department for alcohol overdose decreased 13%, 28%, and 37%, respectively. Programmatic goals and objectives were met. Social marketing interventions appear to be a promising and cost-effective means to reduce high-risk drinking and the associated consequences among college students. Addressing social ramifications appears to be more motivating than conveying the prevalence of high-risk drinking.

scholarly journals Regulation of Alcohol and Acetaldehyde Metabolism by a Mixture of Lactobacillus and Bifidobacterium Species in Human

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1875
Author(s):  
Su-Jin Jung ◽  
Ji-Hyun Hwang ◽  
Eun-Ock Park ◽  
Seung-Ok Lee ◽  
Yun-Jo Chung ◽  
...  
Keyword(s):  
Alcohol Dehydrogenase ◽  
Blood Levels ◽  
Double Blind ◽  
Excessive Alcohol Consumption ◽  
Bifidobacterium Species ◽  
Placebo Capsule ◽  
Safety Parameters ◽  
Excessive Alcohol ◽  
Clinically Significant ◽  
Acetaldehyde Metabolism

Excessive alcohol consumption is one of the most significant causes of morbidity and mortality worldwide. Alcohol is oxidized to toxic and carcinogenic acetaldehyde by alcohol dehydrogenase (ADH) and further oxidized to a non-toxic acetate by aldehyde dehydrogenase (ALDH). There are two major ALDH isoforms, cytosolic and mitochondrial, encoded by ALDH1 and ALDH2 genes, respectively. The ALDH2 polymorphism is associated with flushing response to alcohol use. Emerging evidence shows that Lactobacillus and Bifidobacterium species encode alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) mediate alcohol and acetaldehyde metabolism, respectively. A randomized, double-blind, placebo-controlled crossover clinical trial was designed to study the effects of Lactobacillus and Bifidobacterium probiotic mixture in humans and assessed their effects on alcohol and acetaldehyde metabolism. Here, twenty-seven wild types (ALDH2*1/*1) and the same number of heterozygotes (ALDH2*2/*1) were recruited for the study. The enrolled participants were randomly divided into either the probiotic (Duolac ProAP4) or the placebo group. Each group received a probiotic or placebo capsule for 15 days with subsequent crossover. Primary outcomes were measurement of alcohol and acetaldehyde in the blood after the alcohol intake. Blood levels of alcohol and acetaldehyde were significantly downregulated by probiotic supplementation in subjects with ALDH2*2/*1 genotype, but not in those with ALDH2*1/*1 genotype. However, there were no marked improvements in hangover score parameters between test and placebo groups. No clinically significant changes were observed in safety parameters. These results suggest that Duolac ProAP4 has a potential to downregulate the alcohol and acetaldehyde concentrations, and their effects depend on the presence or absence of polymorphism on the ALDH2 gene.

scholarly journals Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 39
Author(s):  
Akihiko Shibamoto ◽  
Tadashi Namisaki ◽  
Junya Suzuki ◽  
Takahiro Kubo ◽  
Satoshi Iwai ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Biological Markers ◽  
Prediction Accuracy ◽  
Total Bilirubin ◽  
Alcoholic Cirrhosis ◽  
Serum Total Bilirubin ◽  
Excessive Alcohol Consumption ◽  
Significant Difference ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol

: Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

scholarly journals Methods for Estimating Avoidable Costs of Excessive Alcohol Consumption

2021 ◽  
Vol 18 (9) ◽  
pp. 4964
Author(s):  
Beata Gavurova ◽  
Miriama Tarhanicova
Keyword(s):  
Czech Republic ◽  
Alcohol Consumption ◽  
Data Availability ◽  
Excessive Alcohol Consumption ◽  
Public Authorities ◽  
The Czech Republic ◽  
Cost Of Disease ◽  
Lost Productivity ◽  
Excessive Alcohol ◽  
The Cost

Background: Alcohol is a risk factor with serious consequences for society and individuals. This study aims to present methods and approaches that might be used to estimate the costs related to excessive alcohol consumption. It emphasizes the need for general methods and approaches that are easily applicable, because the level of digitalization and data availability vary across regions. The lack of data makes many methods inapplicable and useless. The ease of applicability will help to make cost-of-illness studies and their results comparable globally. Methods: This study is based on data from the Czech Republic in 2017. Drinking alcohol results in costs of healthcare, social care, law enforcement, and administrative costs of public authorities. To quantify the cost of drinking in the Czech Republic, the top-down approach, bottom-up approach, human capital approach and attributable fractions were used. Results: In 2017, the cost related to alcohol was estimated at 0.66% of the national GDP. Lost productivity represented 54.45% of total cost related to alcohol. All cost related to alcohol is considered to be avoidable. Conclusions: The methods and approaches applied to estimate the cost of disease or any other health issue should be generalized regarding the availability of data and specifics of provided services to people who are addicted or have any kind of disability.

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