scholarly journals Discovery of small molecule inhibitors against the NS3/4A serine protease of Hepatitis C virus genotype 3 via highthroughput virtual screening and in vitro evaluations

2020 ◽  
Vol 37 (3) ◽  
pp. 609-625
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virtual Screening ◽  
Serine Protease ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Genotype 3 ◽  
Virus Genotype

Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a

2019 ◽  
Vol 24 (37) ◽  
pp. 4484-4491 ◽  
Author(s):  
Sara M. El-Sayed ◽  
Mohamed A.M. Ali ◽  
Bahaa El-Dien M. El- Gendy ◽  
Samar S. Dandash ◽  
Yvette Issac ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Virus Genotype

Hepatitis C virus genotype 3 was associated with the development of hepatocellular carcinoma in Korea

2019 ◽  
Vol 26 (4) ◽  
pp. 459-465 ◽  
Author(s):  
Sang Soo Lee ◽  
Cha Young Kim ◽  
Bo Ra Kim ◽  
Ra Ri Cha ◽  
Wan Soo Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 3 ◽  
Virus Genotype

scholarly journals In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

2003 ◽  
Vol 77 (6) ◽  
pp. 3669-3679 ◽  
Author(s):  
Caterina Trozzi ◽  
Linda Bartholomew ◽  
Alessandra Ceccacci ◽  
Gabriella Biasiol ◽  
Laura Pacini ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
In Vitro Selection ◽  
Three Dimensional ◽  
Host Cells ◽  
Dimensional Structure ◽  
In Vitro Systems

ABSTRACT The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this enzyme have been identified and shown to inhibit HCV replication in tissue culture. The optimization of these inhibitors for clinical development would greatly benefit from in vitro systems for the identification and the study of resistant variants. We report the use HCV subgenomic replicons to isolate and characterize mutants resistant to a protease inhibitor. Taking advantage of the replicons' ability to transduce resistance to neomycin, we selected replicons with decreased sensitivity to the inhibitor by culturing the host cells in the presence of the inhibitor and neomycin. The selected replicons replicated to the same extent as those in parental cells. Sequence analysis followed by transfection of replicons containing isolated mutations revealed that resistance was mediated by amino acid substitutions in the protease. These results were confirmed by in vitro experiments with mutant enzymes and by modeling the inhibitor in the three-dimensional structure of the protease.

scholarly journals Hepatitis C virus genotype 3 and the risk of severe liver disease in a large population of drug users in France

2010 ◽  
Vol 82 (10) ◽  
pp. 1647-1654 ◽  
Author(s):  
Christine Larsen ◽  
Vanina Bousquet ◽  
Elisabeth Delarocque-Astagneau ◽  
Corinne Pioche ◽  
Françoise Roudot-Thoraval
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Drug Users ◽  
Large Population ◽  
Genotype 3 ◽  
Severe Liver ◽  
Virus Genotype ◽  
Severe Liver Disease

scholarly journals A New Subtype of Hepatitis C Virus Genotype 3: Analysis of Available Evidence

2013 ◽  
Vol 13 (8) ◽  
Author(s):  
Faraz Salehi Moghadam ◽  
Seyed Reza Mohebbi ◽  
Seyed Masoud Hosseini ◽  
Behzad Damavand ◽  
Mohammad Reza Zali
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genotype 3 ◽  
Virus Genotype

Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue

2008 ◽  
Vol 16 (4) ◽  
pp. 1874-1883 ◽  
Author(s):  
Kevin X. Chen ◽  
Bancha Vibulbhan ◽  
Weiying Yang ◽  
Kuo-Chi Cheng ◽  
Rong Liu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Serine Protease ◽  
Protease Inhibitors ◽  
Small Molecule ◽  
Serine Protease Inhibitors
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