scholarly journals Ameliorating effects of vitamin E and coriander (Coriandrum sativum) seed extract on lead-induced renal damage in swiss albino mice

2020 ◽  
Vol 01 (04) ◽  
pp. 181-185
Author(s):  
M. A. Jahid ◽  
I. Hasan ◽  
U. Ayman ◽  
M. Afrin ◽  
M.Z.I. Khan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Renal Damage ◽  
Seed Extract ◽  
Coriandrum Sativum ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Hematological and Histopathological Profiles of Swiss Albino Mice Infected with Plasmodium berghei upon Treatment with Cooked Tetracarpidium conophorum Seed Ethanol Extract

2021 ◽  
pp. 22-37
Author(s):  
Dada Ebenezer ◽  
Oladipo Faith Temiloluwa
Keyword(s):  
Body Weight ◽  
Plasmodium Berghei ◽  
Hematological Parameters ◽  
Haemoglobin Concentration ◽  
Ethanol Extract ◽  
Seed Extract ◽  
Mean Corpuscular Hemoglobin ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Group 5

Aim: This study was conducted to verify the hematological and histopathological outcome of cooked ethanol seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65). Study Design: Descriptive study. Methodology: Standard methods were conducted to determine the phyto-chemical profile of cooked T. conophorum seed ethanol extract, hematological, histopathological indices and biochemical assay. Mice were assembled into five groups (1, 2, 3, 4 and 5) of seven each. The mice in group 4 were treated with a customary antimalarial drug (chloroquine as positive control) at a dose of 5 mg/kg body weight, while mice in groups 3, 2 and 1 was administered with increasing dosages (200, 400, 800 mg/kg body weight) of seed extracts for four consecutive days respectively. Results: The qualitative phytochemical screening of T. conophorum seed extract revealed the presence of bioactive components such as saponin, tannins, flavonoid, terpenoid. Saponin (16.82 mg/100 g) was the highest occurring phytochemical followed by terpenoid (10.39 mg/100 g), glycoside (5.9 mg/100 g), tannin (2.8 mg/100 g) and flavonoid (1.17 mg/100 g), while steroid only had a trace presence. Hematological parameters revealed mice in all groups do not possess significantly different mean corpuscular haemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). Mice in group 5 (infected and not treated) demonstrated lowest values of hemoglobin, platelet, and packed cell volume with a significantly lower % eosin. There was considerable decrease in the levels of alanine transaminase and aspartate transaminase in group 5 compared to mice in groups 1, 2, and 3. Conclusion: Ameliorative effects of seed extract were observed on the liver and kidney of mice at dose levels (200 mg/kg) used, but the 400 mg/kg restored the kidney but had adverse effect on the liver. This study therefore shows that cooked T. conophorum is generally less effective and could not be employed for treatment of malaria.

scholarly journals Analgesic Effect of Ethanolic Extract of Seeds and Leaves of Coriandrum Sativum on Swiss Albino Mice

2021 ◽  
Vol 9 (02) ◽  
pp. 50-55
Author(s):  
Chandrajeet Kumar Yadav ◽  
Poonam Tiwari ◽  
Roshan Mehta ◽  
Amit Kumar Shrivastava ◽  
Anjan Palikhey
Keyword(s):  
Acetic Acid ◽  
Analgesic Effect ◽  
International Association ◽  
Emotional Experience ◽  
Ethanolic Extract ◽  
Coriandrum Sativum ◽  
Hot Plate ◽  
Plate Method ◽  
Swiss Albino Mice ◽  
Albino Mice

INTRODUCTION: Pain has been described by the International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Although NSAIDS and OPIOIDS are available for the treatment, still pain (chronic) is major problem. The present study was designed to study the analgesic effect of ethanolic extract of Coriandrum sativum using hot plate method and acetic acid induced writhing method in experimental animals (Swiss albino mice). MATERIAL AND METHODS:The analgesic effect of leaves and seeds of Coriandrum sativum was assessed using hot plate method and acetic acid induced writhing method in Swiss albino mice. The animals were treated with the ethanolic extract of leaves and seeds of Coriandrum sativum orally at two doses of 100, 500 mg/kg body weight after electric heat and acetic acid induced pain in mice. RESULTS: The study showed that ethanolic extract of leaves and seeds of Coriandrum sativum presented significant (p<0.05) and (p<0.05) analgesic activity in mice simultaneously. The data were analyzed by one-way ANOVA followed by Dunette's multiple comparison test. The results demonstrate that ethanolic extract of leaves and seeds of Coriandrum sativum has got analgesic potential. CONCLUSION: The results demonstrate that ethanolic extract of leaves and seeds of Coriandrum sativum has got significant analgesic effect.

scholarly journals ACUTE TOXICITY STUDIES AND EVALUATION OF ANALGESIC PROPERTY OF TECTONA GRANDIS METHANOLIC SEED EXTRACT IN SWISS ALBINO MICE

2019 ◽  
pp. 106-108
Author(s):  
JHANSI RANI G ◽  
LAKSHMI BHAVANI N
Keyword(s):  
Tectona Grandis ◽  
Immersion Test ◽  
Seed Extract ◽  
Tail Flick ◽  
Tail Flick Test ◽  
Swiss Albino Mice ◽  
Analgesic Property ◽  
Plant Parts ◽  
Wide Range ◽  
Albino Mice

Objective: Tectona grandis which is well known as teak possesses a wide range of applications in Indian and African folklore medicine. All the plant parts are having diverse bioactivities, especially the seeds, having hair growth-promoting activity, anti-inflammatory, and antimicrobial activity. Xanthones, proteins, amino acids, and fatty acids have been isolated from the oil and seeds of T. grandis. Methods: The present study was to explore the antinociceptive properties of methanolic seed extract of T. grandis. Dried seeds of the plant were defatted with non-polar solvents such as petroleum ether and extracted with methanol. Acetic acid-induced writhing test, tail flick test, and tail immersion test were employed for the extract using Swiss albino mice. Results: From the results, it is clear that the methanolic teak seed extract is safe at 1000 mg/kg and having a potent analgesic property (at a dose of 200–250 mg/kg body weight) by inhibiting pain response time. Conclusion: It can be concluded that the methanolic seed extract of T. grandis is analgesic in nature. It is considered as safe and the activity may be due to the presence of various bioactive chemicals such as flavonoids, xanthones, and glycosides.

scholarly journals Anticancer Potential of Aqueous Ethanol Seed Extract ofZiziphus mauritianaagainst Cancer Cell Lines and Ehrlich Ascites Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Tulika Mishra ◽  
Madhu Khullar ◽  
Aruna Bhatia
Keyword(s):  
Cell Lines ◽  
Ehrlich Ascites Carcinoma ◽  
Seed Extract ◽  
Ziziphus Mauritiana ◽  
Dependent Manner ◽  
Swiss Albino Mice ◽  
Ehrlich Ascites ◽  
Albino Mice

Ziziphus mauritiana(Lamk.) is a fruit tree that has folkloric implications against many ailments and diseases. In the present study, anticancer potential of seed extract ofZiziphus mauritiana in vitroagainst different cell lines (HL-60, Molt-4, HeLa, and normal cell line HGF) by MTT assay as well asin vivoagainst Ehrich ascites carcinoma bearing Swiss albino mice was investigated. The extract was found to markedly inhibit the proliferation of HL-60 cells. Annexin and PI binding of treated HL-60 cells indicated apoptosis induction by extract in a dose-dependent manner. The cell cycle analysis revealed a prominent increase in sub Go population at concentration of 20 μg/ml and above. Agarose gel electrophoresis confirmed DNA fragmentation in HL-60 cells after 3 h incubation with extract. The extract also exhibited potent anticancer potentialin vivo. Treatment of Ehrlich ascites carcinoma bearing Swiss albino mice with varied doses (100–800 mg/kg b.wt.) of plant extract significantly reduced tumor volume and viable tumor cell count and improved haemoglobin content, RBC count, mean survival time, tumor inhibition, and percentage life span. The enhanced antioxidant status in extract-treated animals was evident from decline in levels of lipid peroxidation and increased levels of glutathione, catalase, and superoxide dismutase.

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