scholarly journals Antifungal Activity of Gueira senegalensis L. and Mangifera indica L. on Sorghumloose smut pathogen (Sporisorium cruentum (KUHN) POTTER)

2021 ◽  
Vol 6 (1) ◽  
pp. 189-194
Author(s):  
M. M. Hadiza ◽  
◽  
A.S. Kutama ◽  
S. Umar
Keyword(s):  
Fungal Pathogen ◽  
Leaf Extract ◽  
Antifungal Agents ◽  
Mangifera Indica ◽  
Test Organism ◽  
Loose Smut ◽  
Inhibitory Effects ◽  
Antifungal Activities ◽  
Methanolic Extracts ◽  
Guiera Senegalensis

The objective of the research was to determine the antifungal activities of Guiera senegalensis L. and Mangifera indica L. leave extracts against most frequently occurring sorghum pathogen of the loose smut (Sporisorium cruentum) in Nigeria. Methanolic extracts from Guiera senegalensis L. and Mangifera indica L. were tested at concentrations of 250, 125, 62.5, and 31.2mg/ml as potential sources of antifungal agents for Sporisorium cruentum. All extracts exhibited moderate to good activities on the tested fungi with minimum inhibitory concentrations (MICs). The test organism was sensitive to the G. senegalensis extracts, with 14mm and 10mm in diameter at 250mg/ml and 125mg/ml, respectively. The test organism was sensitive to M. indica leaf extract with 12mm in diameter at 250mg/ml. The results showed that both extracts exhibited inhibitory effects at different concentrations against the test organism. Therefore, it is concluded that extracts of G. senegalensis and M. indica could be used in controlling the fungal pathogen of sorghum loose smut (Sporisorium cruentum). Keywords; antifungal activities, Sporisorium cruentum, Guiera senegalensis, Mangifera indica

Antioxidant and Enzyme Inhibitory Properties of Mangifera indica leaf Extract

2020 ◽  
Vol 10 (4) ◽  
pp. 384-394
Author(s):  
Sainiara Begum ◽  
Archana Banerjee ◽  
Bratati De
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Mangifera Indica ◽  
Agricultural Waste ◽  
Ethyl Acetate Fraction ◽  
Soil Amelioration ◽  
Liver Disorders ◽  
Inhibitory Activities

Aims:The foliar residues of Mangiferaindica tree are usually burned or used for soil amelioration except nominal uses as fodder.Methods:To add value to this agricultural waste, extracts of the leafy residues of M. indica were studied to analyze their potential as antioxidants and to inhibit the enzymes related to the management of diabetes, Alzheimer’s Disease (AD), hepatic disorders as well as to identify important phytochemicals present in the extracts.Results:Results depicts that the leaves have notable bioactivities. The methanol extract (ME) showed much potential than ethyl acetate fraction after hydrolysis (HME) against α-amylase and α- glucosidase. The activity against the enzyme β-glucuronidase was also higher than that of the commercial β- glucuronidase inhibitor. The extract after hydrolysis showed better antioxidant and acetylcholinesterase inhibitory activities. Detection of important phytochemicals such as chrysin and myricetn, alizarin, arbutin, hydroquinone, tyrosol, taxifolin, kaempferol, mangiferin, and the vitamin alpha tocophereol, in addition to a number of organic acids, amino acids, fatty acids, sugars and polyols by GC-MS and HPTLC based analysis of the extract of M. indica leaf, also suggest the use of the leaves as sources of these important phytochemicals.Conclusion:More concisely HME with more number of detected metabolites found better to be used against oxidative stress as well as enzymes related to neural and liver disorders than that of ME.

Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Olubukola H. Oyeniran ◽  
Adedayo O. Ademiluyi ◽  
Ganiyu Oboh
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Methanolic Extract ◽  
Array Detector ◽  
Oh Radicals ◽  
Inhibitory Effects ◽  
Methanolic Extracts ◽  
Phenolic Constituents ◽  
Rauvolfia Vomitoria

AbstractObjectivesRauvolfia vomitoria is a medicinal plant used traditionally in Africa in the management of several human diseases including psychosis. However, there is inadequate scientific information on the potency of the phenolic constituents of R. vomitoria leaf in the management of neurodegeneration. Therefore, this study characterized the phenolic constituents and investigated the effects of aqueous and methanolic extracts of R. vomitoria leaf on free radicals, Fe2+-induced lipid peroxidation, and critical enzymes linked to neurodegeneration in rat’s brain in vitro.MethodsThe polyphenols were evaluated by characterizing phenolic constituents using high-performance liquid chromatography coupled with diode array detector (HPLC-DAD). The antioxidant properties were assessed through the extracts ability to reduce Fe3+ to Fe2+; inhibit ABTS, DPPH, and OH radicals and Fe2+-induced lipid peroxidation. The effects of the extracts on AChE and MAO were also evaluated.ResultsThe phenolic characterization of R. vomitoria leaf revealed that there were more flavonoids present. Both aqueous and methanolic extracts of R. vomitoria leaf had inhibitory effects with the methanolic extract having higher significant (p≤0.05) free radicals scavenging ability coupled with inhibition of monoamine oxidases. However, there was no significant (p≤0.05) difference obtained in the inhibition of lipid peroxidation and cholinesterases.ConclusionThis study suggests that the rich phenolic constituents of R. vomitoria leaf might contribute to the observed antioxidative and neuroprotective effects. The methanolic extract was more potent than the aqueous extract; therefore, extraction of R. vomitoria leaf with methanol could offer better health-promoting effects in neurodegenerative condition.

scholarly journals Ionic liquids as potentially new antifungal agents against Alternaria species

RSC Advances ◽  
2020 ◽  
Vol 10 (38) ◽  
pp. 22318-22323
Author(s):  
Maja Karaman ◽  
Milan Vraneš ◽  
Aleksandar Tot ◽  
Snežana Papović ◽  
Dragana Miljaković ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Antifungal Agents ◽  
Antifungal Activities ◽  
Alternaria Species

The objective of this study was to examine the in vitro antifungal activities of 18 newly synthesized ionic liquids (ILs) against three Alternaria strains: A. padwickii, A. dauci and A. linicola.

Mortality and Inhibitory Effects of Aqueous and Methanolic Extracts of Artemisia annua L. on Biomphalaria pfeifferi (Krauss) and Shedding of Cercariae

2021 ◽  
Vol 42 (1) ◽  
pp. 25-30
Author(s):  
I.M. Ado ◽  
Z.A. Ali ◽  
M.M. Dogara ◽  
K. Abdullahi ◽  
S.A Luka ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Artemisia Annua ◽  
Scientific Evidence ◽  
Standard Procedure ◽  
Inhibitory Effect ◽  
Control Group ◽  
Inhibitory Effects ◽  
Biomphalaria Pfeifferi ◽  
Artemisia Annua L ◽  
Methanolic Extracts

The search for bioactive plants which can be used as non-conventional anthelmintics has received considerable attention in recent times because of the increasing, worldwide development of resistance to synthetic anthelminthes worm populations. However, scientific evidence to validate the use of raw plants materials remain limited. This study evaluated the mortality and inhibitory effects of the crude aqueous and methanolic extract of Artemisia annua L. against the shedding of cercariae of Schistosoma mansoni from Biomphalaria pfeifferi. The phytochemical screening of the plant was done using standard procedure, after which the mortality effects of the plant extracts and effects on the shedding of cercariae from B. pfeifferi snails were assessed for 24 hour of exposure. Methanolic extract with the highest concentration of 1.77mg/µL had an inhibitory effect of 63.06±1.84 while the least concentration with 0.12mg/µL had 22.41±2.17 inhibitory effect. For the aqueous extract, the highest concentration with 2.73mg/µL had an inhibitory effect of  55.75±1.94 while the least concentration of 0.23mg/µL had 21.80±1.45. Inhibitory effect of cercariae in the snail vector was  concentration dependent, and there was significance difference (P<0.05) between the treatment mean when compared with the control group. This study has shown that this plant material has some inhibitory effect on the shedding of of S. mansoni cercariae and toxicityeffect on the B. pfeifferisnails, and can therefore be used for the control of the disease causing agent as well as the vector. Keywords: Artemisia annua, Inhibitory effects, cercariae, Biomphalaria pfeifferi

scholarly journals Antifungal Agents: Design, Synthesis, Antifungal Activity and Molecular Docking of Phloroglucinol Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3116 ◽  
Author(s):  
Xingxing Teng ◽  
Yuanyuan Wang ◽  
Jinhua Gu ◽  
Peiqi Shi ◽  
Zhibin Shen ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Antifungal Activity ◽  
Protein Binding ◽  
Binding Site ◽  
Antifungal Agents ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Protein Binding Site ◽  
Antifungal Activities ◽  
Phloroglucinol Derivatives

Pseudoaspidinol is a phloroglucinol derivative with Antifungal activity and is a major active component of Dryopteris fragrans. In our previous work, we studied the total synthesis of pseudoaspidinol belonging to a phloroglucinol derivative and investigated its antifungal activity as well as its intermediates. However, the results showed these compounds have low antifungal activity. In this study, in order to increase antifungal activities of phloroglucinol derivatives, we introduced antifungal pharmacophore allylamine into the methylphloroglucinol. Meanwhile, we remained C1–C4 acyl group in C-6 position of methylphloroglucinol using pseudoaspidinol as the lead compound to obtain novel phloroglucinol derivatives, synthesized 17 compounds, and evaluated antifungal activities on Trichophyton rubrum and Trichophyton mentagrophytes in vitro. Molecular docking verified their ability to combine the protein binding site. The results indicated that most of the compounds had strong antifungal activity, in which compound 17 were found to be the most active on Trichophyton rubrum with Minimum Inhibitory Concentration (MIC) of 3.05 μg/mL and of Trichophyton mentagrophytes with MIC of 5.13 μg/mL. Docking results showed that compounds had a nice combination with the protein binding site. These researches could lay the foundation for developing antifungal agents of clinical value.

scholarly journals Phytochemical Analysis, Cytotoxcity and Antifungal Activities of Guiera Senegalensis Leaves Extract Review

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Hassan Mustapha Gurama ◽  
Fatima Mohammed Maude ◽  
Mogoro Umar Jibrin ◽  
Omotainse Simon Oluwatovi ◽  
Ali Alhaji Sani ◽  
...  
Keyword(s):  
Phytochemical Analysis ◽  
Antifungal Activities ◽  
Guiera Senegalensis

scholarly journals FT-IR analysis of Sapium ellipticum (Hochst) pax ethanol leaf extract and its inhibitory effects on pancreatic α-amylase and intestinal α-glucosidase activities in vitro

2016 ◽  
Vol 3 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Osasenaga Macdonald Ighodaro ◽  
Oluseyi Adeboye Akinloye ◽  
Regina Ngozi Ugbaja ◽  
Samuel Olatunbosun Omotainse ◽  
Opeyemi Faokunla
Keyword(s):  
Leaf Extract ◽  
Inhibitory Effects ◽  
Ft Ir ◽  
Ir Analysis

scholarly journals Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata

mSphere ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Sarah G. Whaley ◽  
Kelly E. Caudle ◽  
Lucia Simonicova ◽  
Qing Zhang ◽  
W. Scott Moye-Rowley ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Antifungal Agents ◽  
Common Species ◽  
Negative Regulator ◽  
Gene Encoding ◽  
Fluconazole Resistance ◽  
Mechanism Of Resistance ◽  
Primary Mechanism ◽  
Activating Mutation

Candida glabrata is the second most common species of Candida recovered from patients with invasive candidiasis. The increasing number of infections due to C. glabrata, combined with its high rates of resistance to the commonly used, well-tolerated azole class of antifungal agents, has limited the use of this antifungal class. This has led to the preferential use of echinocandins as empirical treatment for serious Candida infections. The primary mechanism of resistance found in clinical isolates is the presence of an activating mutation in the gene encoding the transcription factor Pdr1 that results in upregulation of one or more of the efflux pumps Cdr1, Pdh1, and Snq2. By developing a better understanding of this mechanism of resistance to the azoles, it will be possible to develop strategies for reclaiming the utility of the azole antifungals against this important fungal pathogen.

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