Association between hyperuricemia and clinical pathological characteristics of patients with IgA nephropathy

2021 ◽  
Vol 71 (8) ◽  
pp. 1930-1934
Author(s):  
Ling Lu ◽  
Bin Li ◽  
Guohua Dai ◽  
Yi Feng ◽  
Huaguo Feng
Keyword(s):  
Iga Nephropathy ◽  
Pathological Characteristics

Published in August 2021

scholarly journals MON-053 CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF IgA NEPHROPATHY WITH AKD

2019 ◽  
Vol 4 (7) ◽  
pp. S326
Author(s):  
J.J. Zhang ◽  
Y.Y. Du ◽  
Y.F. Wei ◽  
D. Yu ◽  
Y.L. Wang ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Pathological Characteristics

scholarly journals Evaluation of Clinical and Pathological Characteristics of Patients with IgA Nephropathy Based on Oxford Classification System: Should Crescents be Included?

2017 ◽  
Vol 15 (1) ◽  
pp. 10-15
Author(s):  
Sibel Ersan ◽  
Omur Gokmen Sevindik ◽  
Caner Cavdar ◽  
Sibel Ada ◽  
Aykut Sifil ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Classification System ◽  
Clinical Course ◽  
Immunoglobulin A ◽  
Classification Systems ◽  
Oxford Classification ◽  
Crescent Formation ◽  
Pathological Characteristics ◽  
The Oxford Classification

Abstract Introduction. None of the classification systems in immunoglobulin A (IgA) nephropathy has been widely agreed or implemented by clinicians or pathologists. In order to meet this need, "Oxford Classification System", which is highly reproducible and predictive for clinical course, was developed in 2009. In the present study, we investigated clinical and pathological characteristics of patients with IgA nephropathy based on current classification and the predictivity of crescent presence on prognosis. Methods. The study comprised 40 patients with diagnosis of primary IgA nephropathy on renal biopsy. The biopsy findings and follow-up parameters of patients were retrospectively re-evaluated. Pathological findings were examined based on the Oxford classification system. The presence of crescent formation in the specimens was noted. Results. The presence of crescent formation was predictive of poor prognosis regarding the glomerular filtration rate (eGFR), the level of proteinuria, and mean arterial pressure (MAP). Conclusion: Considering the importance of crescent formation in prediction of the clinical course and need for immunosuppressive therapy, it is suggested that crescent presence can be included in this classification system.

scholarly journals Association of URG11 and Twist with clinical pathological characteristics and prognosis in patients with IgA nephropathy

2013 ◽  
Vol 28 (9) ◽  
pp. 2268-2276 ◽  
Author(s):  
R. Du ◽  
L. Zhao ◽  
L. Xia ◽  
L. Liu ◽  
W. Sun ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Pathological Characteristics

scholarly journals IgA NEPHROPATHY IN CHILDREN: A MODIFIED VIEW OF CLINICO-PATHOLOGICAL CHARACTERISTICS

1980 ◽  
Vol 14 (8) ◽  
pp. 995-995 ◽  
Author(s):  
C Nakahara ◽  
F Aosai ◽  
O Hasegawa ◽  
H Ito ◽  
N Matsuo ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Pathological Characteristics

Clinical and pathological characteristics of Fabry disease combined with IgA nephropathy in Chinese patients

2017 ◽  
Vol 87 (04) ◽  
pp. 188-195 ◽  
Author(s):  
Nannan Yang ◽  
Xia Wang ◽  
Feng Xu ◽  
Caihong Zeng ◽  
Jinquan Wang ◽  
...  
Keyword(s):  
Fabry Disease ◽  
Iga Nephropathy ◽  
Chinese Patients ◽  
Pathological Characteristics

scholarly journals Immune Characteristics of IgA Nephropathy With Minimal Change Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Huixian Li ◽  
Wanhong Lu ◽  
Haiyun Li ◽  
Xiaoling Liu ◽  
Xue Zhang ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Minimal Change Disease ◽  
Estimated Glomerular Filtration Rate ◽  
Mesangial Cells ◽  
Minimal Change ◽  
Substantial Evidence ◽  
Pathological Characteristics ◽  
High Degree ◽  
Degree Of Heterogeneity

Background: IgA nephropathy (IgAN) has a high degree of heterogeneity in clinical and pathological features. Among all subsets of IgAN, the pathogenesis of IgAN with minimal change disease (MCD-IgAN) remained controversial.Methods: We analyzed the clinical and pathological characteristics of MCD-IgAN patients in a retrospective cohort. Patients diagnosed with IgAN, excluding MCD-IgAN, were randomly selected as controls. Levels of plasma galactose-deficient IgA1 (GdIgA1), IgG autoantibodies against GdIgA1, GdIgA1 deposition in the glomerulus, and inflammatory reactivity of circulating poly-IgA1 complexes to cultured mesangial cells were evaluated.Results: Patients with MCD-IgAN had significantly higher levels of proteinuria and estimated glomerular filtration rate (eGFR), lower levels of albumin and urine blood cells, and milder histological lesions by a light microscope compared to IgAN patients, which bears a resemblance to MCD. Lower levels of GdIgA1 (3.41 ± 1.68 vs. 4.92 ± 2.30 μg/ml, p = 0.009) and IgG antiglycan autoantibodies (23.25 ± 22.59 vs. 76.58 ± 71.22 IU/ml, p < 0.001) were found in MCD-IgAN patients than those in IgAN controls. Meanwhile, weaker fluorescence intensities of both IgA and GdIgA1 were observed in the glomerulus of MCD-IgAN patients compared to those in IgAN patients. Furthermore, poly-IgA1 complexes from MCD-IgAN patients induced weaker inflammatory effects on cultured mesangial cells than those from IgAN patients in vitro.Conclusion: The results demonstrated that MCD-IgAN cases represent a dual glomerulopathy, namely, mild IgAN with superimposed MCD, which furthermore provides substantial evidence for the corticosteroids therapy in MCD-IgAN patients as the guidelines recommended.

Interstitial inflammation and the expression of apoptotic modulators in iga nephropathy

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A114-A114
Author(s):  
Menahem Sa ◽  
Maguire Ja ◽  
Stein‐Oakley A ◽  
Bailey M ◽  
Dowling J ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Interstitial Inflammation

264: Anatomic Distribution and Pathological Characteristics of Prostate Cancer in Korean Men: A Mapping Analysis

2006 ◽  
Vol 175 (4S) ◽  
pp. 88-88
Author(s):  
Cheryn Song ◽  
Taejin Kang ◽  
Gil Hyun Shin ◽  
Donglk Shin ◽  
Jae Y. Ro ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Pathological Characteristics ◽  
Mapping Analysis ◽  
Anatomic Distribution
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