scholarly journals In-vitro prostate cancer biomarker detection by directed conjugation of anti-PSCA antibody to super paramagnetic iron oxide nanoparticless

2019 ◽  
Author(s):  
Mahboube Shahrabi Farahani ◽  
Monireh Mohsenzadegan ◽  
Jaleh Taeb ◽  
Mohammad M Farajollahi
Keyword(s):  
Prostate Cancer ◽  
Iron Oxide ◽  
Cancer Biomarker ◽  
Biomarker Detection ◽  
Super Paramagnetic Iron Oxide

Chemically tunable cationic polymer-bonded magnetic nanoparticles for gene magnetofection

2014 ◽  
Vol 2 (6) ◽  
pp. 644-650 ◽  
Author(s):  
Makoto Takafuji ◽  
Kumiko Kitaura ◽  
Takuro Nishiyama ◽  
Srinath Govindarajan ◽  
Vijaya Gopal ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Viral Vectors ◽  
Cationic Polymer ◽  
Oxide Nanoparticles ◽  
Super Paramagnetic Iron Oxide

This study evaluates the efficiency of novel non-viral vectors consisting of super paramagnetic iron oxide nanoparticles functionalized with the chemically tunable cationic polymer forin vitrogene magnetofection.

scholarly journals An electrochemical biosensor for prostate cancer biomarker detection using graphene oxide-gold nanostructures

2019 ◽  
Vol 19 (3) ◽  
pp. 206-216 ◽  
Author(s):  
Zahra Akbari jonous ◽  
Javad Shabani Shayeh ◽  
Fatemeh Yazdian ◽  
Amir Yadegari ◽  
Mohadeseh Hashemi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Graphene Oxide ◽  
Electrochemical Biosensor ◽  
Cancer Biomarker ◽  
Gold Nanostructures ◽  
Biomarker Detection

scholarly journals Electrochemical Detection of Prostate Cancer Biomarker PCA3 Using Specific RNA-Based Aptamer Labelled with Ferrocene

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 59
Author(s):  
Alexei Nabok ◽  
Hisham Abu-Ali ◽  
Sarra Takita ◽  
David P. Smith
Keyword(s):  
Prostate Cancer ◽  
Electrochemical Impedance Spectroscopy ◽  
Impedance Spectroscopy ◽  
Electrochemical Impedance ◽  
Cancer Biomarker ◽  
Affinity Constant ◽  
Cyclic Voltammograms ◽  
Cathodic Current ◽  
Transfer Resistance

This paper reports on a feasibility study of electrochemical in-vitro detection of prostate cancer biomarker PCA3 (prostate cancer antigen 3) in direct assay with specific RNA aptamer labelled with a redox group (ferrocene) and immobilized on a screen-printed gold electrode surface. The cyclic voltammograms and electrochemical impedance spectroscopy methods yield encouraging results on the detection of PCA3 in a range of concentrations from 1 μg/mL down to 0.1 ng/mL in buffer solutions. Both anodic and cathodic current values in cyclic voltammograms measurements and charge transfer resistance values in electrochemical impedance spectroscopy experiments correlate with the PCA3 concentration in the sample. Kinetics studies of the binding of the PCA3 to our aptamer demonstrated high specificity of the reaction with a characteristic affinity constant of approximately 4·10−10 molar. The results of this work provide a background for the future development of novel, highly sensitive and cost-effective diagnostic methodologies for prostate cancer detection.

scholarly journals CRISPR/Cas-Based In Vitro Diagnostic Platforms for Cancer Biomarker Detection

2021 ◽  
Vol 93 (35) ◽  
pp. 11899-11909
Author(s):  
Shaohua Gong ◽  
Shiqi Zhang ◽  
Fei Lu ◽  
Wei Pan ◽  
Na Li ◽  
...  
Keyword(s):  
Cancer Biomarker ◽  
Biomarker Detection ◽  
In Vitro Diagnostic
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