scholarly journals ENVISIONING OF RASASHASTRA IN PRESENT PANDEMIC

2021 ◽  
Vol 09 (1) ◽  
pp. 200-204
Author(s):  
Vidhiya Malviya ◽  
Pramod Patel ◽  
Anil Nagle
Keyword(s):  
Chronic Diseases ◽  
Critical Review ◽  
Communicable Disease ◽  
Treatment Protocol ◽  
Symptomatic Treatment ◽  
Pharmaceutical Science ◽  
Wide Range ◽  
Small Doses ◽  
Therapeutic Utility

Rasashastra- A pharmaceutical science has following characteristic attributes i.e. instant effectiveness, re-quirement of very small doses and extensive therapeutic utility irrespective of statutory variation. Aims – To know the variety of formulation for SARS CoV-2 and also know the kind of disinfectant or sanitizer of Rasa medicine. Material and Method - Rasa medicine with its huge importance on treating chronic diseases also beneficiary in making disinfectant. Critical review of Rasashastra treatises give some beneficiary for-mulation that can be used in this pandemic. Result – List of herbo-mineral formulation from different Rasashastra treatises are compiled. This formulation plays very important role in treating communicable disease from stopping the spread of virus to treat the disease and also symptomatic treatment with particular medicine. Conclusion - In present time a big threat for human civilization is come in the form of corona ep-idemic and become pandemic. This is one of the challenges towards whole world that how to combat with the situation. Presently when no one knows the treatment, Ayurveda plays a very important role with its huge Ayurvedic formulations and unique strategy of treatment protocol. A Pharmaceutical science “Rasashastra” plays a very indispensable role because of wide range of Ayurvedic formulations described in Rasashastra treatises along with wide therapeutic utility.

PHENOTHIAZINE TRANQUILIZERS AS A CAUSE OF SEVERE SEIZURES

PEDIATRICS ◽  
1959 ◽  
Vol 23 (3) ◽  
pp. 485-492
Author(s):  
Edward B. Shaw ◽  
Robert V. Dermott ◽  
Raymond Lee ◽  
T. N. Burbridge
Keyword(s):  
Side Effects ◽  
Symptomatic Treatment ◽  
Careful Observation ◽  
Small Doses

The phenothiazine tranquilizer drugs should not be used indiscriminately for symptomatic treatment without due appreciation of the alarming and potentially serious side effects which may follow relatively small doses, especially in childhood. Minimal dosage, due warning to parents of possible symptoms, and careful observation are essential precautions for physicians who use these agents.

In Support of Initial Parenteral Medical Management of Intrathecal Baclofen Withdrawal in Spasticity Patients

2021 ◽  
pp. 875512252110392
Author(s):  
Brian L. LaRowe ◽  
Vicki M. Nussbaum
Keyword(s):  
Case Reports ◽  
Treatment Plan ◽  
Correct Diagnosis ◽  
Treatment Protocol ◽  
Patient Characteristics ◽  
Clinical Problem ◽  
Clinical Situation ◽  
Intrathecal Baclofen ◽  
Wide Range ◽  
Baclofen Withdrawal

Background: Spasticity may present as a wide range of symptoms and conditions. With this protean presentation, a consensus regarding the best course of treatment does not exist. Those patients most severely affected may receive significant benefit from intrathecal baclofen delivery. However, this therapy may itself lead to patient injury in the event of withdrawal. Objective: Withdrawal from intrathecal baclofen may devolve rapidly into a situation in which the patient may incur significant morbidity and even death. A focused, prompt treatment plan would afford the patient the best possible outcome. Methods: The medical literature was reviewed for reports of plans of treatment of baclofen withdrawal and the results obtained. The nature of this problem does not lend itself to a typical study design, depending on case reports and basic pharmacological science application. The paucity of such reports severely limits categorical comparison of patient characteristics and clinical circumstances. Clinical situations, patient characteristics, and therapies were considered and compared. Outcomes of the varied treatments were evaluated for efficacy. Results: Inaccurate diagnoses, delayed correct diagnoses, and the absence of a consistent, treatment plan contributed to widely disparate outcomes. Prompt, correct diagnosis and intensive care unit–based continuous benzodiazepine infusion with titration led to a controlled clinical situation and maximized patient outcomes. Conclusions: Patients going through withdrawal from intrathecal baclofen achieved best outcomes when treated with a continuous infusion and titration of an intravenous benzodiazepine. A well-defined treatment protocol employing this management, reporting serial outcomes, would enable further refinement of the treatment of this clinical problem.

scholarly journals Prevalence of health misinformation in social media: a systematic review (Preprint)

2019 ◽  
Author(s):  
Victor Suarez-Lledo ◽  
Javier Alvarez-Galvez
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Social Media ◽  
Eating Disorders ◽  
Communicable Disease ◽  
Health Concern ◽  
Public Health Concern ◽  
Medical Treatments ◽  
Wide Range ◽  
Social Media Platforms

BACKGROUND The propagation of health misinformation through social media has become a major public health concern over the last two decades. Although today there is broad agreement among researchers, health professionals, and policy makers on the need to control and combat health misinformation, the magnitude of this problem is still unknown. Consequently, before adopting the necessary measures for the adequate control of health misinformation in social media, it is fundamental to discover both the most prevalent health topics and the social media platforms from which these topics are initially framed and subsequently disseminated. OBJECTIVE This systematic review aims to identify the main health misinformation topics and their prevalence on different social media platforms, focusing on methodological quality and the diverse solutions that are being implemented to address this public health concern. METHODS This systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines (PRISMA). We searched PubMed, MEDLINE, Scopus and the Web of Science for articles published in English before March 2019 with a particular focus on studying health misinformation in social media. We defined health misinformation as a health-related claim based on anecdotal evidence, false, or misleading due to the lack of existing scientific knowledge. The criteria for inclusion were: 1) articles that focused on health misinformation in social media, including those in which the authors discussed the consequences or purposes of health misinformation; and 2) studies that described empirical findings regarding the measurement of health misinformation in these platforms. RESULTS A total of 69 studies were identified as eligible, covering a wide range of health topics and social media platforms. The topics were articulated around six principal categories: vaccines (32%), drugs or smoking (22%), non-communicable disease (19%), pandemics (10%), eating disorders (9%), and medical treatments (7%). Studies were mainly based on five methodological approaches: Social Network Analysis (28%), Evaluating Content (26%), Evaluating Quality (24%), Content/Text analysis (16%) and Sentiment Analysis (6%). Health misinformation proved to be the most more prevalent in studies related to smoking products and drugs such as opioids or marijuana. Posts with misinformation reached 87% in some studies focused in smoking products. Health misinformation about vaccines was also very common (43%), but studies reported different levels of misinformation depending on the different vaccines, with the Human Papilloma Virus (HPV) vaccine being the most affected. Secondly, health misinformation related to diets or pro eating disorders (pro-ED) arguments were moderate in comparison to the aforementioned topics (36%). Studies focused on diseases (i.e. non-communicable diseases and pandemics) also reported moderate misinformation rates (40%), especially in the case of cancer. Finally, the lowest levels of health misinformation were related to medical treatments (30%). CONCLUSIONS Prevalence of health misinformation was most common on Twitter and on issues related to smoking products and drugs. However, misinformation is also high on major public health issues such as vaccines and diseases. Our study offers a comprehensive characterization of the dominant health misinformation topics and a comprehensive description of their prevalence in different social media platforms, which can guide future studies and help in the development of evidence-based digital policy actions plans. CLINICALTRIAL

The EMDR Integrative Group Treatment Protocol for Patients With Cancer

2016 ◽  
Vol 10 (3) ◽  
pp. 199-207 ◽  
Author(s):  
Ignacio Jarero ◽  
Lucina Artigas ◽  
Susana Uribe ◽  
Laura Evelyn García
Keyword(s):  
Stress Responses ◽  
Traumatic Stress ◽  
Group Treatment ◽  
Terminal Illness ◽  
Treatment Protocol ◽  
Individual Treatment ◽  
Adult Women ◽  
Patients With Cancer ◽  
Wide Range ◽  
Adolescents And Adults

Experiencing cancer is a peculiar stressor within the infrastructure of posttraumatic stress disorder (PTSD) because this debilitating disease involves ongoing stressors and is both acute and potentially chronic. The experience can include a wide range of associated adverse events, such as tumor detection, diagnosis, severity of disease, and prognosis; aggressive treatment; disfigurement and bodily dysfunction; side effects of treatment; impaired physical, social, and occupational functioning; and sometimes, recurrence and diagnosis of terminal illness. This article provides a detailed description of the clinical application of the Eye Movement Desensitization and Reprocessing (EMDR) Integrative Group Treatment Protocol (EMDR-IGTP) Adapted for Adolescents and Adults Living with Ongoing Traumatic Stress for the patients with cancer. This protocol administers the eight phases of EMDR individual treatment to a group of patients using an art therapy format (i.e., drawings) and the butterfly hug (a self-administered bilateral stimulation method to process traumatic material). A previous study (Jarero et al., 2015) showed that after 6 sessions of EMDR-IGTP, there was a significant decrease in PTSD symptoms related to the diagnosis and treatment of different types of cancer in adult women. Effects were maintained at 90-day follow-up. In this article, we discuss how this protocol can be used to effectively provide intensive EMDR treatment to large groups of patients, and we provide detailed instructions for its provision to address one of the major psychological dimensions of cancer: the ongoing traumatic stress responses experienced by patients with cancer. A clinical example illustrates the treatment process.

The Milan System for Reporting Salivary Gland Cytopathology: Assessment of Cytohistological Concordance and Risk of Malignancy

2020 ◽  
pp. 1-13
Author(s):  
Shilpy Jha ◽  
Suvradeep Mitra ◽  
Suvendu Purkait ◽  
Amit Kumar Adhya
Keyword(s):  
Salivary Gland ◽  
Predictive Value ◽  
Malignant Tumors ◽  
Minor Salivary Gland ◽  
Treatment Protocol ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Wide Range ◽  
Risk Of Malignancy

<b><i>Introduction:</i></b> The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was proposed by the American Society of Cytopathology and the International Academy of Cytology to bring uniformity in the reporting system and the treatment protocol. A wide range of risk of malignancy for each category has been reported by various authors by applying the system. <b><i>Aim:</i></b> We intend to study the cytohistological concordance and the ROM for each of the diagnostic categories of the Milan system. <b><i>Materials and Methods:</i></b> The study included 292 cases of fine-needle aspiration cytology (FNAC) of salivary gland lesions over a period of 3 years. The diagnosis of these cases was reclassified into the 6 categories of the Milan system. The cytohistological concordance and ROM for each category of the Milan system were calculated based on the clinical and histopathological follow-up. <b><i>Results:</i></b> The patients’ age ranged from 3 to 81 years with the mean of 42.65 ± 16.3 years. The cases included 189 (64.7%) parotid, 82 (28.1%) submandibular, and 21 (7.2%) cases of minor salivary gland swellings. Follow-up histopathological diagnosis for 102 cases was available. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated to be 64.28, 97.01, 90, 86.67, and 87.37%, respectively. After reclassification, the number of cases in each category was as follows: category I: 31 (10.62%), category II: 80 (27.4%), category III: 2 (0.68%), category IVA: 143 (48.97%), category IVB: 1 (0.34%), category V: 13 (4.45%), and category VI: 22 (7.53%). The calculated ROM was as follows: category I: 42.86%, category II: 26.67%, category III: 100% category IVA: 10.17%, category IVB: 0%, category V: 71.42%, category VI: 100%. <b><i>Conclusion:</i></b> FNAC is an excellent procedure to differentiate benign from malignant tumors, and MSRSGC is a useful system for risk assessment and deciding the further treatment protocol. Our findings also suggest that in addition to the surgical follow-up, inclusion of the clinical and radiological follow-up may be a better strategy for calculation of ROM, especially for categories I and II.

Equine Melanotic Disease

1971 ◽  
Vol 57 (3) ◽  
pp. 133-168 ◽  
Author(s):  
Arnold Levene
Keyword(s):  
Critical Review ◽  
Behaviour Pattern ◽  
Review Of The Literature ◽  
Chemically Induced ◽  
Wide Range ◽  
Blue Naevus ◽  
The Subject

After a description of the morbid anatomical and histological appearances of equine melanotic disease, the author provides a critical review of the literature. The histogenesis is demonstrably via dermal melanocytic proliferation. By comparing the equine disease with spontaneously occurring and chemically induced dermal melanocytic tumours in the hamster, and with the wide range of behaviour pattern seen in the human blue naevus, also the subject of a review, he concludes that equine melanotic disease is best considered as a special manifestation of the blue naevus phenomenon.

Asset Based Approaches for Community Engagement

2016 ◽  
Author(s):  
Katrina Wyatt ◽  
Robin Durie ◽  
Felicity Thomas
Keyword(s):  
Public Health ◽  
Low Income ◽  
Environmental Science ◽  
Service Providers ◽  
Communicable Disease ◽  
Poor Health ◽  
Local Context ◽  
Forthcoming Article ◽  
Wide Range ◽  
Policies And Programs

This is an advance summary of a forthcoming article in the Oxford Research Encyclopedia of Environmental Science. Please check back later for the full article. The burden of ill health has shifted, globally, from communicable to non-communicable disease, with poor health clustering in areas of economic deprivation. However, for the most part, public health programs remain focused on changing behaviors associated with poor health (such as smoking or physical inactivity) rather than the contexts that give rise to, and influence, the wide range of behaviors associated with poor health. This way of understanding and responding to population ill health views poor health behavior as a defining “problem” exhibited by a particular group of individuals or a community, which needs to be solved by the intervention of expert practitioners. This sort of approach determines individuals and their communities in terms of deficits, and works on the basis of perceived needs within such communities when seeking to address public health issues. Growing recognition that many of the fundamental determinants of health cannot be attributed solely to individuals, but result instead from the complex interplay between individuals and their social, economic, and cultural environments, has led to calls for new ways of delivering policies and programs aimed at improving health and reducing health inequalities. Such approaches include the incorporation of subjective perspectives and priorities to inform the creation of “health promoting societal contexts.” Alongside this, asset-based approaches to health creation place great emphasis on valuing the skills, knowledge, connections, and potential within a community and seek to identify the protective factors within a neighborhood or organization that support health and wellbeing. Connecting Communities (C2) is a unique asset-based program aimed at creating the conditions for health and wellness within very low-income communities. At the heart of the program is the belief that health emerges from the patterns of relations within neighborhoods, rather than being a static attribute of individuals. C2 seeks to change the nature of the relations both within communities and with service providers (such as the police, housing, education, and health professionals) to co-create responses to issues that are identified by community members themselves. While many of the issues identified concern local environmental conditions, such as vandalism or safe out-door spaces, many are also contributory determinants of ill health. Listening to people, understanding the social, cultural, and environmental context within which they are located, and supporting new partnerships based on reciprocity and mutual benefit ensures that solutions are grounded in the local context and not externally determined, in turn resulting in sustainable health creating communities.

scholarly journals Further Development of Near-Infrared Mediated Quantum Dots and Paclitaxel Co-loaded Nanostructured Lipid Carrier System for Cancer Theragnostic

2020 ◽  
Vol 19 ◽  
pp. 153303382091430
Author(s):  
Livesey D. Olerile
Keyword(s):  
Quantum Dots ◽  
Cancer Treatment ◽  
Hepg2 Cells ◽  
Near Infrared ◽  
Early Stage ◽  
Treatment Protocol ◽  
Nanostructured Lipid Carriers ◽  
Nanostructured Lipid Carrier ◽  
Wide Range ◽  
Mcf 7

Of colloidal systems, ceteris paribus, nanostructured lipid carriers are second to none in offering a single-unit platform for multifunctional benefits. Quantum dots are known to possess unique properties that make them ideal for imaging purpose and that they may be used for cancer detection. For several decades, paclitaxel has been the most effective drug against a wide range of solid tumours. Theragnostic nanomedicine provides a platform to monitor, evaluate, and individualize treatment in real time. Evaluation of cancer treatment outcome at an early stage therapy is key to increase survival prospects of a patient. Previously, a novel co-loaded nanostructured lipid carriers’ theragnostic system for parenteral administration was developed. The aim of this study was to further investigate the co-loaded nanostructured lipid carriers in order to provide interpretation necessary for preclinical elucidation of the formulation, in part. The co-loaded nanostructured lipid carriers were prepared by oil/water emulsification-solvent evaporation technique. In this study, stability and co-loaded nanostructured lipid carriers’ internalization by MCF 7 and HepG2 cells were investigated. The co-loaded nanostructured lipid carriers was stable at 4°C for 1 month. The formulation was successfully internalized by MCF-7 and HepG2 cells. Nevertheless, the co-loaded nanostructured lipid carrier was more apt for MCF-7 cells. This finding affirms the formulation to be the most appropriate for breast cancer treatment. In addition, if taken correctly by a patient for a month, the formulation would give true reflection of the contents’ amounts, the factor paramount to appropriate changes in treatment protocol. It can therefore safely be concluded that the co-loaded nanostructured lipid carrier formulation may be potentially an effective theragnostic translational system.

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