scholarly journals Protective effect of gallic acid derivatives from the freshwater green alga Spirogyra sp. against ultraviolet B-induced apoptosis through reactive oxygen species clearance in human keratinocytes and zebrafish

ALGAE ◽  
2017 ◽  
Vol 32 (4) ◽  
pp. 379-388 ◽  
Author(s):  
Lei Wang ◽  
BoMi Ryu ◽  
Won-Suk Kim ◽  
Gwang Hoon Kim ◽  
You-Jin Jeon
Keyword(s):  
Reactive Oxygen Species ◽  
Protective Effect ◽  
Gallic Acid ◽  
Green Alga ◽  
Reactive Oxygen ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Oxygen Species ◽  
Induced Apoptosis

UVB-induced apoptosis and DNA damaging potential of chrysene via reactive oxygen species in human keratinocytes

2011 ◽  
Vol 204 (2-3) ◽  
pp. 199-207 ◽  
Author(s):  
Daoud Ali ◽  
A. Verma ◽  
F. Mujtaba ◽  
A. Dwivedi ◽  
R.K. Hans ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Human Keratinocytes ◽  
Oxygen Species ◽  
Induced Apoptosis

Elevated basal reactive oxygen species and phospho-Akt in murine keratinocytes resistant to ultraviolet B-induced apoptosis

2003 ◽  
Vol 37 (3) ◽  
pp. 149-157 ◽  
Author(s):  
Brent D. Butts ◽  
Kevin A. Kwei ◽  
G. Tim Bowden ◽  
Margaret M. Briehl
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Ultraviolet B ◽  
Oxygen Species ◽  
Induced Apoptosis

scholarly journals Role of Reactive Oxygen Species in Gallic Acid-Induced Apoptosis.

2000 ◽  
Vol 23 (10) ◽  
pp. 1153-1157 ◽  
Author(s):  
Makoto INOUE ◽  
Nahoko SAKAGUCHI ◽  
Kazuto ISUZUGAWA ◽  
Hiroyuki TANI ◽  
Yukio OGIHARA
Keyword(s):  
Reactive Oxygen Species ◽  
Gallic Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Induced Apoptosis

Bergenin Exhibits Hepatoprotective Activity Against Ethanol-Induced Oxidative Stress in ICR Mice

2019 ◽  
Vol 18 (4) ◽  
pp. 297-302
Author(s):  
Sriset Yollada ◽  
Chatuphonprasert Waranya ◽  
Jarukamjorn Kanokwan
Keyword(s):  
Reactive Oxygen Species ◽  
Gallic Acid ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Hepatic Injury ◽  
Reduced Glutathione ◽  
Reactive Oxygen ◽  
Hepatoprotective Activity ◽  
Oxygen Species ◽  
Hepatic Glutathione

Bergenin is a C-glucoside derivative of gallic acid but its antioxidant and hepatoprotective effects have not previously been compared with gallic acid. Male ICR mice were administered bergenin (10, 50, and 250 mg/kg/day) or gallic acid (100 mg/kg/day) for 7 consecutive days before a single administration of ethanol (5 g/kg). Liver sections were histopathologically examined. Aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde levels were determined in plasma. Total glutathione, reduced glutathione, and oxidized glutathione levels were determined in liver homogenates. Ethanol induced hepatic injury with prominent histopathological markers including nuclear pyknosis and necrotic areas and this accorded with increases in the plasma levels of aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde. Moreover, ethanol disturbed hepatic glutathione homeostasis by reducing glutathione stores. Hepatic injury in the ethanol-induced mice was prevented with bergenin and gallic acid by significant decreases in plasma aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde levels and restoration of the hepatic glutathione profile through an increase in the reduced glutathione/oxidized glutathione ratio. Bergenin at 10 mg/kg/day showed comparable hepatoprotective activity to gallic acid in an ethanol-induced mouse model of oxidative stress. Therefore, bergenin might be a promising candidate for further development as a novel hepatoprotective product.

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