scholarly journals Effect of Chlorella on blood pressure, cerebral stroke lesions, hypertensive vascular changes and life-span in spontaneously hypertensive rats.

1987 ◽  
Vol 40 (5) ◽  
pp. 351-359 ◽  
Author(s):  
Tetsuo MURAKAMI ◽  
Kozo OKAMOTO ◽  
Masahiro OGAKI ◽  
Yoshitomi IIZUKA
Keyword(s):  
Blood Pressure ◽  
Life Span ◽  
Spontaneously Hypertensive Rats ◽  
Cerebral Stroke ◽  
Vascular Changes ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats

2019 ◽  
Vol 42 (5) ◽  
pp. 610-617 ◽  
Author(s):  
Zinat Mahal ◽  
Koichi Fujikawa ◽  
Hiroyuki Matsuo ◽  
Hasan M. Zahid ◽  
Masamichi Koike ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Life Span ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Influence of chronic nadolol treatment on blood pressure and vascular changes in spontaneously hypertensive rats

1992 ◽  
Vol 70 (9) ◽  
pp. 1261-1270 ◽  
Author(s):  
Robert M. K. W. Lee ◽  
Jim Tsoporis ◽  
Roger R. J. Wang
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Spontaneously Hypertensive Rats ◽  
Muscle Cells ◽  
Mesenteric Arteries ◽  
Control Group ◽  
Vascular Changes ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Chronic treatment of spontaneously hypertensive rats (SHR) and Kyoto–Wistar normotensive rats (WKY) with nadolol was carried out from gestation until 28 weeks of age. Nadolol treatment caused some lowering of blood pressure but did not prevent the development of hypertension or cardiac hypertrophy in the SHR, in spite of significant β-blockade. The lumen of large mesenteric arteries from control SHR was smaller than from WKY, and nadolol treatment increased the lumen size in the SHR. An increased number of smooth muscle cell layers present in the control SHR as compared with WKY was reduced slightly by nadolol treatment. However, the changes produced by nadolol did not reach the levels of control and treated WKY. In the aorta, the incidence of polyploid smooth muscle cells was higher in the SHR than the WKY in the control group. Nadolol treatment reduced the percentage of polyploid cells in both SHR and WKY, so that the difference between these two groups of animals was eliminated in the treated groups. The tissue level of norepinephrine in the plasma, heart, mesenteric arteries, and adrenal glands in the SHR and WKY was not affected by the treatment. We suggest that the ineffectiveness of nadolol in preventing hypertension development may be due to its lack of effect in preventing primary changes in the resistance arteries, and that the development of polyploidy of smooth muscle cells may be mediated by β-receptors.Key words: nadolol, vascular changes, hypertension, spontaneously hypertensive rats, β-receptor, catecholamines.

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