scholarly journals I-3-1 Operative results and problematic considerations of aorto-coronary bypass surgery for ischemic heart disease

1981 ◽  
Vol 11 (1) ◽  
pp. 84-86
Author(s):  
M. Osawa
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Bypass Surgery ◽  
Coronary Bypass ◽  
Ischemic Heart ◽  
Coronary Bypass Surgery ◽  
Operative Results

scholarly journals Dynamics of parameters of oxidative stress in blood of ischemic heart disease patients before and after coronary bypass surgery

2012 ◽  
Vol 11 (4) ◽  
pp. 13-17
Author(s):  
N. L. Vorontsova ◽  
M. V. Bogdanov ◽  
А. S. Golovkin ◽  
R. A. Mukhamadiyarov ◽  
Ye. V. Grigoriyev ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Bypass Surgery ◽  
Coronary Bypass ◽  
Ischemic Heart ◽  
Coronary Bypass Surgery ◽  
Before And After

The dynamics of indicators of inflammation, antioxidant defense and myocardium ischemia under coronary bypass surgery using artificial blood circulation and on functioning heart

2016 ◽  
Vol 22 (3) ◽  
pp. 116-120
Author(s):  
Olesya A. Rubanenko ◽  
O. V Fatenkov ◽  
S. M Khokhlunov ◽  
L. V Limareva
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Blood Circulation ◽  
Bypass Surgery ◽  
Antioxidant Defense ◽  
Coronary Bypass ◽  
Ischemic Heart ◽  
Coronary Bypass Surgery ◽  
Artificial Blood ◽  
Artificial Blood Circulation

The article considers evaluation of indicators of inflammation, antioxidant defense and myocardium ischemia in patients with ischemic heart disease exposed to coronary bypass surgery using artificial blood circulation or on functioning heart. The sampling included 96 patients distributed to two groups. The first group included 84 patients (81% of males, average age 62,2±7,7 years) exposed to coronary bypass surgery in conditions of artificial blood circulation. The second group included 12 patients (91,7% of males, average age 59,8±8,0 years) exposed to coronary bypass surgery on functioning heart without artificial blood circulation. The study demonstrated significant increasing of level of interleukin-6 in patients with ischemic heart disease after application of coronary bypass surgery with extra-corporal blood circulation that confirms high activity of inflammation factors at the given disease. The reconstructing operations on hearts in conditions of artificial blood circulation are accompanied by decreasing of concentration of superoxiddismutase. At that, the level of analyzed bio-marker remains as compared with operation on functioning heart. This occurrence testifies activation of oxidative process and intensified consumption of as factor of antioxidant defense in the course of direct re-vascularization of myocardium. The concentration of troponin increases in post-operational period of reconstructing operation but differences are unreliable when analyzed groups are compared.

scholarly journals The Pathways to Increase the Efficacy of Drug Therapy in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting

Kardiologiia ◽  
2019 ◽  
Vol 59 (6) ◽  
pp. 12-17
Author(s):  
O. L. Barbarash ◽  
V. V. Kashtalap ◽  
M. V. Zykov ◽  
O. N. Hryachkova ◽  
I. A. Shibanova
Keyword(s):  
Heart Disease ◽  
Drug Therapy ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Coronary Artery Bypass ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Coronary Bypass ◽  
Ischemic Heart

Purpose: to assess drug therapy and achievement of target parameters of treatment in patients with ischemic heart disease (IHD) during 3–5 years of follow-up aſter coronary bypass surgery.Materials and methods. From the initial sample of the coronary bypass surgery registry (n=680) we selected for this study 111 men (mean age 61 [55; 65] years) hospitalized in 2011 with clinical picture of IHD for coronary artery bypass graſting (CABG).Results. Mean duration of follow-up was 4.2 years. Mortality was 11.7 % (n=13), 11 deaths were cardiovascular, 2 – from unknown causes. End points defined as repeat hospitalizations and IHD progression were registered in 18 of 98 patients (18.4 %). Only in 25 % of patients during 3–5 years of observation aſter CABG there were no clinical signs of angina. Five patients (5.1 %) developed new type 2 diabetes. Drug therapy: 80 patients (81.6 %) received acetylsalicylic acid, 60 (61.2 %) – angiotensin converting enzyme inhibitors, 80 (81.6 %) – β-adrenoblockers. Eighty-one men (82.6 %) received statins, but only 20 of 98 re-examined patients (20.4 %) took high doses. Target levels of low density lipoprotein cholesterolConclusion. Data of clinical practice illustrate insufficient quality of basic and antianginal therapy in patients with IHD aſter CABG. Indicators of control of angina, heart rate, achievement of target levels of parameters of lipid metabolism remain unsatisfactory.

scholarly journals Predoperatsionnaya terapiya statinamiu patsientov s ishemicheskoy bolezn'yu serdtsa

2011 ◽  
Vol 2 (1) ◽  
pp. 51-54
Author(s):  
Ol'ga Leonidovna Barbarash ◽  
Yuliya Vyacheslavovna Bayrakova ◽  
Evgeniya Mikhaylovna Kurguzova
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Statin Therapy ◽  
Bypass Surgery ◽  
Heart Diseases ◽  
Coronary Bypass ◽  
Ischemic Heart ◽  
Coronary Bypass Surgery ◽  
Ischemic Heart Diseases

Summary. The need for statins in patients with acute and chronic forms of coronary heart disease is now beyond doubt. However, there is still a view that from the perspective of safety it is necessary to cancel statins before a surgery and reinstitute them after a surgery. This review examines the feasibility and safety of preoperative statin therapy in patients with ischemic heart diseases before planned coronary bypass surgery.

P4416Influence of rosuvastatin on the secretion of leptin and its receptor by adipocytes isolated from different adipose depots in patients with ischemic heart disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y A Dyleva ◽  
O Gruzdeva ◽  
E Uchasova ◽  
D Borodkina ◽  
E Belik ◽  
...  
Keyword(s):  
Cell Culture ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Leptin Receptor ◽  
Artery Bypass ◽  
Coronary Bypass ◽  
Economic Problem ◽  
Ischemic Heart ◽  
Leptin Resistance

Abstract Obesity is still a major health, social and economic problem throughout the world. Recently, it is important to study the role of adipokines of adipose tissue of various localization in the development of cardiovascular diseases, as well as methods for their pharmacological correction. Purpose The study was to evaluate the effect of rosuvastatin on the secretion of leptin and its receptor by adipocytes of different localization, as well as on the expression of their genes in patients with ischemic heart disease. Methods 29 patients with coronary heart disease which will be held coronary bypass surgery. Adipocytes were isolated from the samples of SAT, EAT and PVAT obtained during coronary artery bypass grafting, which were cultured for 24 hours with rosuvastatin 1 μmol/l and 5 μmol/l. A day later, the concentration of leptin and the leptin receptor in cell culture was determined. All study was carried out in compliance with the Helsinki Declaration, and its protocol was approved by the Ethical Committee of Research Institute. Statistical analysis was performed using Statistica 10.0. All patients gave written informed consent to participate in the study. Results 1 μmol/l of rosuvastatin increased the level of leptin 1.6 and 2.9 times higher in adipocytes SAT compared with EAT and PVAT, respectively, and 1.8 times higher in EAT than in PVAT, which is consistent with the results of expression leptin gene. The concentration of rosuvastatin 5 μmol/l had an effect only on adipocytes SAT, increasing the level of leptin 1.6 and 2.2 times in comparison with adipocytes EAT and PVAT. Rosuvastatin had no significant effect on leptin receptor soluble levels. The free leptin index was higher in adipocytes SAT in the presence of 1 μmol/l of rosuvastatin 1.6 and 2.8 times in comparison with adipocytes of EAT and PVAT. Conclusion The concentration of rosuvastatin 1 μmol/l had a more pronounced effect on adipocytes compared to a concentration of 5 μmol/l and increased the level of leptin and its expression in cell culture. At the same time, a high content of leptin under conditions of low expression of a soluble receptor to leptin in the presence of rosuvastatin 1 μmol/l can lead to leptin resistance, more pronounced in SAT adipocytes.

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