scholarly journals Different modalities for treatment of recurrent aphthous stomatitis. A Randomized clinical trial

2016 ◽  
pp. 0-0 ◽  
Author(s):  
SA Nasry ◽  
HM El Shenawy ◽  
D Mostafa ◽  
NM Ammar
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis

scholarly journals Comparison of therapeutic effect of mucoadhesive Nano-triamcinolone gel and conventional triamcinolone gel on recurrent aphthous stomatitis

2019 ◽  
Vol 22 (4) ◽  
pp. 554-560
Author(s):  
Shahla Mirzaee ◽  
Zahra Golestannejad ◽  
Rastin Sadeghian ◽  
Bita Rohani ◽  
Saeid Sadeghian
Keyword(s):  
Clinical Trial ◽  
Statistical Analysis ◽  
Randomized Clinical Trial ◽  
Triamcinolone Acetonide ◽  
Therapeutic Effect ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Chi Square ◽  
Before And After ◽  
Keratinized Mucosa

Objective: Recurrent aphthous stomatitis (RAS) is characterized by recurring ulcers, with well-defined margins. The lesions are confined to the oral mucosa (usually seen in non-keratinized mucosa). The disease manifests in the form of outbreaks, with a chronic and self-limiting course in most cases. Since the cause of the disease is unknown, many drugs have been studied to palliate the symptoms. Treatment used is multifocal and varies according to the predisposing factors. The aim of this study was to investigate the effect of recombinant Nano-based triamcinolone acetonide gel and compare it with conventional triamcinolone gel on RAS. Material and methods: In this triple-blind randomized clinical trial study, sixty patients with minor aphthous lesions were divided into two groups receiving conventional triamcinolone (CT) and Nano-based triamcinolone (NT). The patients were requested to apply drug four times a day for a week. The severity of pain (through VAS) and the size of the lesions (mean of the largest diameter of the lesions) were evaluated on starting day and days 2, 4, 6 after the intervention. Statistical analysis was performed using chi square and independent t-test. Findings were significant with P < 0.05. Findings: Of the 60 patients enrolled in the study, 5 patients did not continue; 21 (38.2%) cases were female and 34 (61.8%) cases were male (P=0.6). The severity of pain in NT group before and after the study was 1.4 ± 5.2 and 1.8 ± 1.3 cm, respectively and in CT group was 48.1 ± 1 and 1.8 ± 1.3 cm. The size of the lesions in NT group before and at the end of the study was 0.96 ± 0.1 and 0.18 ± 0.1   cm, respectively and in CT group was 0.93 ± 0.1 and 0.19 ± 0.1 cm.  Among the mentioned variables, only size of lesions on the 2nd and 4th days had a significant reduction in NT group in comparison with CT group. Conclusion: The size of lesions showed a significant reduction on the 2nd and 4th days in NT group in comparison with CT group, therefore NT has a better impact on RAS in comparison with CT.KEYWORDSNanoparticle; Recurrent aphthous stomatitis; Treatment; Triamcinolone.

scholarly journals Comparison of colchicine versus prednisolone in recurrent aphthous stomatitis: A double-blind randomized clinical trial

2010 ◽  
Vol 33 (3) ◽  
pp. 189 ◽  
Author(s):  
Atessa Pakfetrat ◽  
Arash Mansourian ◽  
Fatemeh Momen-Heravi ◽  
Zahra Delavarian ◽  
Jalil Momen-Beitollahi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Randomized Clinical Trial ◽  
Signs And Symptoms ◽  
Similar Efficacy ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Definitive Treatment ◽  
Therapeutic Effects ◽  
Double Blind

Purpose: Recurrent aphthous stomatitis (RAS) is one of the most common ulcers of the oral cavity with a reported prevalence of 5- 50%. There is still no definitive treatment for RAS; however, immunosuppressive and immunomodulant agents have been proposed. In this study, we compared the therapeutic effects of 5 mg/d prednisolone with 0.5 mg/d colchicine in the treatment of RAS. Methods: In a double-blind randomized clinical trial, 34 patients with RAS were randomly divided into two groups for treatment with prednisolone or colchicine. All patients took the medication for three months and were assessed at two weeks intervals. The groups were compared for size and number of lesions, severity of pain and burning sensation, duration of pain-free episodes and any side effects of the prescribed medicines. Both colchicine and prednisolone treatments significantly reduced RAS (p < 0.001). No significant differences in size and number of lesions, recurrence and severity of pain and duration of pain-free period were seen between the two treatment groups. Colchicine (52.9%) had significantly more side effects than prednisolone (11.8%). Conclusion: Low dose prednisolone and colchicine were both effective in treating RAS. Given that the two therapies had similar efficacy, yet colchicine was associated with more side effects, , 5mg/d of prednisolone seems to be a better alternative in reducing the signs and symptoms of the disease.

scholarly journals Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial

10.19082/6912 ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 6912-6919 ◽  
Author(s):  
Fatemeh Rahmani ◽  
Ali Akbar Moghadamnia ◽  
Sohrab Kazemi ◽  
Atena Shirzad ◽  
Mina Motallebnejad
Keyword(s):  
Clinical Trial ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind
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