scholarly journals Effect of 0.5% Chitosan mouthwash on recurrent aphthous stomatitis: a randomized double-blind crossover clinical trial

10.19082/6912 ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 6912-6919 ◽  
Author(s):  
Fatemeh Rahmani ◽  
Ali Akbar Moghadamnia ◽  
Sohrab Kazemi ◽  
Atena Shirzad ◽  
Mina Motallebnejad
Keyword(s):  
Clinical Trial ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind

scholarly journals Evaluation of the Effectiveness of the Iralvex Gel on the Recurrent Aphthous Stomatitis Management

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Heidar Khademi ◽  
Pedram Iranmanesh ◽  
Ali Moeini ◽  
Atefeh Tavangar
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Complete Healing ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
The Other ◽  
Definitive Treatment ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Pain Duration

Introduction. As there is no definitive treatment for the recurrent aphthous stomatitis (RAS), most of the available therapies aim at decreasing pain and discomfort. The aim of this study was to investigate the effectiveness of the Iralvex gel on the RAS management. Material and Methods. In this double-blind and placebo-controlled clinical trial study, twenty patients were treated with the Iralvex gel and the other twenty patients were treated with placebo. In every participant complete healing of lesions, pain duration, and intensity were evaluated. Data were analyzed by independent t-test and analysis of variance. Results. Pain was relieved after 6.10 ± 0.29 days in the Iralvex group in comparison to 8.00 ± 0.33 days in the placebo group (P value ≤0.001). Complete remission in the Iralvex group was after 6.80 ± 0.27 days and 10.20 ± 0.42 days in the placebo group (P value ≤ 0.001). Furthermore, significant differences in the pain intensity between Iralvex and placebo group measured on days 1, 3, and 5 were obtained (P value ≤ 0.01). Conclusion. The results of this study show that Iralvex gel is effective and cheap remedy for treatment of RAS without side effects. This trial is registered with IRCT201207253251N3.

scholarly journals Comparison of colchicine versus prednisolone in recurrent aphthous stomatitis: A double-blind randomized clinical trial

2010 ◽  
Vol 33 (3) ◽  
pp. 189 ◽  
Author(s):  
Atessa Pakfetrat ◽  
Arash Mansourian ◽  
Fatemeh Momen-Heravi ◽  
Zahra Delavarian ◽  
Jalil Momen-Beitollahi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Randomized Clinical Trial ◽  
Signs And Symptoms ◽  
Similar Efficacy ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Definitive Treatment ◽  
Therapeutic Effects ◽  
Double Blind

Purpose: Recurrent aphthous stomatitis (RAS) is one of the most common ulcers of the oral cavity with a reported prevalence of 5- 50%. There is still no definitive treatment for RAS; however, immunosuppressive and immunomodulant agents have been proposed. In this study, we compared the therapeutic effects of 5 mg/d prednisolone with 0.5 mg/d colchicine in the treatment of RAS. Methods: In a double-blind randomized clinical trial, 34 patients with RAS were randomly divided into two groups for treatment with prednisolone or colchicine. All patients took the medication for three months and were assessed at two weeks intervals. The groups were compared for size and number of lesions, severity of pain and burning sensation, duration of pain-free episodes and any side effects of the prescribed medicines. Both colchicine and prednisolone treatments significantly reduced RAS (p < 0.001). No significant differences in size and number of lesions, recurrence and severity of pain and duration of pain-free period were seen between the two treatment groups. Colchicine (52.9%) had significantly more side effects than prednisolone (11.8%). Conclusion: Low dose prednisolone and colchicine were both effective in treating RAS. Given that the two therapies had similar efficacy, yet colchicine was associated with more side effects, , 5mg/d of prednisolone seems to be a better alternative in reducing the signs and symptoms of the disease.

Results of Double-Blind Placebo-Controlled Challenge with Nickel Salts in Patients Affected by Recurrent Aphthous Stomatitis

2003 ◽  
Vol 131 (4) ◽  
pp. 296-300 ◽  
Author(s):  
M.L. Pacor ◽  
G. Di Lorenzo ◽  
N. Martinelli ◽  
G. Lombardo ◽  
A. Di Gregoli ◽  
...  
Keyword(s):  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Double Blind ◽  
Double Blind Placebo
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