scholarly journals Demographic data of patients with β-thalassemia major recorded in the electronic system in the north of Iran, 2016

2018 ◽  
Vol 20 (3) ◽  
Author(s):  
Mehrnoush Kosaryan ◽  
Hossein Karami ◽  
Hadi Darvishi-Khezri ◽  
Rozita Akbarzadeh ◽  
Aily Aliasgharian ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Information Source ◽  
Demographic Data ◽  
Epidemiological Data ◽  
Electronic System ◽  
Thalassemia Major ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Prevention Project ◽  
Clinical Records

Background: Major thalassemia prevention project in Iran began in 1997. Mazandaran Province in northern Iran took effective steps in preventing the birth of patients with thalassemia major in the country. We report on the demographic status of patients with thalassemia major registered in the electronic system of Mazandaran Province in Iran.Methods: The web-based application of the Mazandaran Thalassemia Registry (THRegistry) was designed based on the Net Framework platform in VB.Net and the 2014Sql Server database. The information source included clinical records in 14 thalassemic wards of the Mazandaran province hospitals. Epidemiological data of patients and date of transfusion, blood group, educational status, employment, marital status and having children were recorded.Results: The study population was 1,725 patients including 889 (51.5%) women and 836 (48.5%) men with a mean age of 30±9.6 years. A total of 188 patients born have been identified after the launch of the country's disease prevention plan in 1997. Prenatal diagnosis (PND) services were not used in 99 cases, PND result was mistaken in 6 other cases and in the remaining 5 cases PND was performed. A total of 1,314 patients (76.2%) were blood transfusion dependent thalassemia (TDT). Mean haemoglobin level in male and female patients was 9.4±6.3 and 9.01±5.1/100 g/dl, respectively. The mean age of onset of transfusion was 4±6.3 years. A total of 382 cases (22.1%) of married patients had a child of their own.Conclusions: The system is a good resource to design descriptive and cohort studies, survival studies, therapeutic planning, and observation of the success of the major thalassemia prevention project.

Treatment Status of Patients with Β-Thalassemia Major in Northern Iran: Thalassemia Registry System

2020 ◽  
Author(s):  
Mehrnoush KOSARYAN ◽  
Hossein KARAMI ◽  
Hadi DARVISHI-KHEZRI ◽  
Rosetta AKBARZADEH ◽  
Aily ALIASGHARIAN ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Blood Group ◽  
Chelating Agent ◽  
Thalassemia Major ◽  
Iron Chelators ◽  
Beta Thalassemia ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Packed Red Blood Cells ◽  
Registry System

Background: Electronic registry system of beta-thalassemia patients was run by Thalassemia Research Center (TRC) in 2017. The aim of the current study was presentation of therapeutic status in these patients at Mazandaran Province, Iran. Methods: Therapeutic status variables including: Name of cities and hospitals, age and sex of patients, dependent and non-transfusion-dependent, starting age of the blood transfusion and iron-chelating agents, blood group and Rh, washed blood transfusion, abnormal antibody, transfusion reactions, mean hemoglobin during the last 3 months, type of iron chelators, iron chelators dosage, serum ferritin, and the use of hydroxyurea. Results: Overall, 1831 patients were registered [891 male (48.7%)]. Mean age of patients was 30±9.7 yr. Average of hemoglobin levels for female and male were 9.1±5.1 and 9.4±6.3 gr/dl, respectively. Seventy-six percent of transfusion-dependent patients (1385) have received iso-group PRBC (packed red blood cells), after crossmatch. The most common blood group among patient was type O-positive (35.7%). Monotherapy with desferrioxamine was most type of used iron-chelating agent in these patients (47.2%). Mean of ferritin was 3300±7800 (ng/ml). Twenty-eight percent of patients (484) have received hydroxyurea; proportion of male and female was approximately equal. T2 weighted magnetic resonance imaging (MRIT2*) was measured in 62.2% of patients. Moderate and severe hepatosiderosis was 10.1% and 2.9%, respectively. Patients with moderate and severe cardiac siderosis were 11% and 5%, respectively. Conclusion: Registry findings are valuable for treatment management and ensuring patients medications. It will also provide accessibility to various levels of patients’ information for health care managers and experts to help them make appropriate decisions.

scholarly journals Geospatial analysis and epidemiological aspects of human infections with Blastocystis hominis in Mazandaran Province, northern Iran

2019 ◽  
Vol 41 ◽  
pp. e2019009 ◽  
Author(s):  
Shabnam Asfaram ◽  
Ahmad Daryani ◽  
Shahabeddin Sarvi ◽  
Abdol Sattar Pagheh ◽  
Seyed Abdollah Hosseini ◽  
...  
Keyword(s):  
High Risk ◽  
Infection Rate ◽  
Demographic Data ◽  
Spatial Association ◽  
Age Groups ◽  
Blastocystis Hominis ◽  
Mazandaran Province ◽  
Intestinal Protozoan ◽  
Northern Iran ◽  
The North

OBJECTIVES: Blastocystis hominis is a very common large intestinal protozoan with global prevalence in humans and non-human hosts. No precise statistics exist regarding the geographical distribution of Blastocystis that would enable the identification of high-risk communities. Therefore, the current research aimed to characterize the spatial patterns and demographic factors associated with B. hominis occurrence in northern Iran.METHODS: The current study was performed among 4,788 individuals referred to health centers in Mazandaran Province, from whom stool samples were obtained. Socio-demographic data were gathered using a questionnaire. Samples were examined by a direct wet mount, the formalin-ethyl acetate concentration technique, and trichrome staining. Moran local indicators of spatial association and a geographically weighted regression model were utilized to analyze the results.RESULTS: Generally, the infection rate of Blastocystis parasites was 5.2%, and was considerably higher in the age group of 10-14 years (10.6%) than in other age groups (p=0.005). Our data showed important associations between the occurrence of B. hominis and age, residence, job, contact with domestic animals, anti-parasitic drug consumption, and elevation above sea level (p<0.001).CONCLUSIONS: The current study characterized for the first time the infection rate and risk of B. hominis in the north of Iran, and produced a prediction map. It is expected that this map will help policymakers to plan and implement preventive measures in high-risk areas and to manage already-infected patients.

scholarly journals Seroprevalence of Hydatidosis in People Referring to Refer-ence Laboratory of Gorgan, Golestan Province, Northern Iran 2017

2019 ◽  
Author(s):  
Saman FATHI ◽  
Reza GHASEMIKHAH ◽  
Rasool MOHAMMADI ◽  
Farideh TOHIDI ◽  
Mitra SHARBATKHORI
Keyword(s):  
Demographic Data ◽  
Cross Sectional Study ◽  
Reference Laboratory ◽  
Medical Sciences ◽  
Igg Antibody ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Cross Sectional ◽  
Blood Samples ◽  
Golestan Province

Background: Hydatidosis is a neglected global zoonotic disease, caused by larval stage of the cestode Echinococcus granulosus in human and animal. Because of high economic and medical importance of the disease, this study was performed to find the seroprevalence of human hydatidosis in Gorgan City, Golestan Province, northern Iran. Methods: In this cross-sectional study, blood samples were collected from people referring to Reference laboratory of Golestan University of Medical sciences in 2017. A relevant questionnaire was completed for demographic data for each person. Echinococcus IgG antibody was investigated by ELISA using native antigen B. The data were analyzed using SPSS software applying logistic regression. Results: Overall, 612 blood samples were collected. Cut-off value was considered 0.29. Sixteen cases (2.6%) were seropositive for hydatidosis. The seroprevalence of hydatidosis was 2.3% and 4.7% among males and females, respectively. There was no statistically significant correlation between the hydatidosis and investigated variables such as sex, age, tribes, residence, education, etc. Conclusion: The prevalence of human hydatidosis shows approximately the same range as other regions of Iran. Although due to the neighboring the Mazandaran Province reported as the highest seroprevalence of hydatidosis, we expected more rate of seropositivity.

scholarly journals 273 The Consequences of a Failed Screening Programme

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
M Sharrock ◽  
C Whelton ◽  
R Paton
Keyword(s):  
Screening Programme ◽  
Demographic Data ◽  
Late Presentation ◽  
Developmental Dysplasia ◽  
Late Diagnosis ◽  
Operation Rate ◽  
Increasing Trend ◽  
The Uk ◽  
Clinical Records ◽  
Surgical Treatments

Abstract Introduction Controversy exists surrounding the efficacy of the UK screening programme for developmental dysplasia of the hip (DDH). Method Clinical records were reviewed in children who were treated surgically for DDH. Demographic data, age and mode of presentation, and surgical treatments were analysed, as well as outcomes, re-operation rate and AVN incidence. Late diagnosis was defined as greater than 4 months. Results 106 children (16 male, 90 female) underwent surgery from 1997 to 2018. 95 hips were operated for dislocation and 22 were operated for dysplasia. 13 patients had bilateral dislocations. Of the dislocated hips, the median age at diagnosis was 9 months (IQR 2-19). 56% were diagnosed late. In the late diagnosis group the median age for diagnosis was 19 months (IQR 15-21). We have identified an increasing trend in late presentation in recent years. This has been matched with an increasing trend in operation rates for dislocation per 1000 births. Conclusions This study demonstrates that DDH is being diagnosed increasingly late, which correlates with an increased need for surgical management. This suggests that the current UK screening programme is failing to identify children with DDH in a timely fashion, which necessitates more aggressive surgical treatment and less favourable outcomes.

scholarly journals Management of ongoing direct anticoagulant treatment in patients with hip fracture

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carlo Rostagno ◽  
Alessandro Cartei ◽  
Gianluca Polidori ◽  
Roberto Civinini ◽  
Alice Ceccofiglio ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Demographic Data ◽  
Drug Intake ◽  
Control Group ◽  
Complication Rates ◽  
Adherence To Guidelines ◽  
Time To Surgery ◽  
Clinical Records ◽  
Current Guidelines ◽  
Type Of Fracture

AbstractAim of the present study was to investigate the effects of ongoing treatment with DOACs on time from trauma to surgery and on in-hospital clinical outcomes (blood losses, need for transfusion, mortality) in patients with hip fracture. Moreover we evaluated the adherence to current guidelines regarding the time from last drug intake and surgery. In this observational retrospective study clinical records of patients admitted for hip fracture from January 2016 to January 2019 were reviewed. 74 patients were in treatment with DOACs at hospital admission. Demographic data, comorbidities and functional status before trauma were retrieved. As control group we evaluated 206 patients not on anticoagulants matched for age, gender, type of fracture and ASA score. Time to surgery was significantly longer in patients treated with DOACs (3.6 + 2.7 vs. 2.15 ± 1.07 days, p < 0.0001) and treatment within 48 h was 47% vs. 80% in control group (p < 0.0001). The adherence to guidelines’ suggested time from last drug intake to surgery was 46%. Neither anticipation nor delay in surgery did result in increased mortality, length of stay or complication rates with the exception of larger perioperative blood loss (Hb levels < 8 g/dl) in DOACs patients (34% vs 9% p < 0.0001). Present results suggest that time to surgery is significantly longer in DOAC patients in comparison to controls and adherence to guidelines still limited.

scholarly journals Epidemiological aspects of retrovirus (HTLV) infection among Indian populations in the Amazon Region of Brazil

2003 ◽  
Vol 19 (4) ◽  
pp. 901-914 ◽  
Author(s):  
Ricardo Ishak ◽  
Antonio Carlos Rosário Vallinoto ◽  
Vânia Nakauth Azevedo ◽  
Marluísa de Oliveira Guimarães Ishak
Keyword(s):  
Molecular Subtype ◽  
Demographic Data ◽  
Epidemiological Data ◽  
Indigenous Communities ◽  
Laboratory Diagnosis ◽  
Amazon Region ◽  
Human Migration ◽  
Migration Routes ◽  
Modes Of Transmission ◽  
Clear Cut

HTLV was initially described in association with a form of leukemia in Japan and a neurological disease in the Caribbean. It was soon shown that HTLV-II was endemic among Amerindians and particularly among Brazilian Indians. The Amazon Region of Brazil is presently the largest endemic area for this virus and has allowed several studies concerning virus biology, the search for overt disease, epidemiological data including detailed demographic data on infected individuals, clear-cut geographic distribution, definition of modes of transmission and maintenance within small, epidemiologically-closed groups, and advances in laboratory diagnosis of the infection. A new molecular subtype named HTLV-IIc was further described on the basis of genome sequencing and phylogenetic analysis. This subtype is present in other areas of Brazil, indicating that the virus is additionally both a valuable marker for tracing past human migration routes in the Americas and a probable marker for social habits of the present human population. HIV, the other human retrovirus, is still not prevalent among indigenous communities in the Brazilian Amazon, but these groups are also easy targets for the virus.

First new species of the family Stigmocheylidae (Acari: Prostigmata: Paratydeoidea) from Asia

2018 ◽  
Vol 23 (11) ◽  
pp. 2159
Author(s):  
Mohammad Reza Damavandian ◽  
Saeid Paktinat-Saeij
Keyword(s):  
New Species ◽  
Identification Key ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Adult Females ◽  
The Family ◽  
A New Species

A new species, Stigmocheylus persicus sp. nov. (Trombidiformes: Prostigmata: Stigmocheylidae) is described based on adult females from Noor, Mazandaran province, northern Iran. The new species can be distinguished from other species by the following features: non-segmented peritremes; absence of setae c3; presence of setae g2; coxa II with four setae; genu I with nine setae; tarsi I–IV with 24(+2ω)–11(+1ω)-11-10 setae. This finding presents the first new species of the family Stigmocheylidae Berlese, 1910 from Asia. Additionally, an identification key to known species of Stigmocheylus is updated.

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