scholarly journals Drug induced aseptic meningitis: A diagnostic challenge

2014 ◽  
Vol 41 (2) ◽  
pp. 138 ◽  
Author(s):  
AI Frank-Briggs ◽  
OJ Oluwatade
Keyword(s):  
Aseptic Meningitis ◽  
Diagnostic Challenge ◽  
Drug Induced

scholarly journals Aseptic meningitis, hepatitis and cholestasis induced by trimethoprim/sulfamethoxazole: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
J. A. A. van Asperdt ◽  
R. A. De Moor
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Liver Injury ◽  
Aseptic Meningitis ◽  
Cholestatic Hepatitis ◽  
Diagnostic Challenge ◽  
Drug Induced ◽  
Case Presentation ◽  
Drug Induced Liver Injury ◽  
Inflammatory Drugs

Abstract Background Drug-induced aseptic meningitis is a rare, but challenging diagnosis, most commonly reported with nonsteoroidal anti-inflammatory drugs (NSAIDs) and antibiotics. Trimethoprim/sulfamethoxazole (TMP/SMX) is a sulfonamide that is widely used in clinical practice for the treatment and prophylaxis of various infections. The most common side effects associated with TMP/SMX are generally mild and self-limited, but serious side effects have been reported, including liver injury and aseptic meningitis. Case presentation We report a 2,5 year old Dutch girl with both drug-induced aseptic meningitis and drug-induced liver injury while using TMP/SMX prophylaxis. Ursodeoxycholic acid was started because of cholestatic injury. After cessation of TMP/SMX, full convalescence was reached within weeks. Conclusions This is the first report of a young patient with both aseptic meningitis and drug-induced liver injury caused by TMP/SMX. Drug-induced aseptic meningitis and cholestatic hepatitis constitute a considerable diagnostic challenge to clinicians. In addition to a thorough evaluation for infectious causes, clinicians should be aware of drug-induced aseptic meningitis and cholestatic hepatitis.

scholarly journals Ibuprofen-Induced Aseptic Meningitis in a Male Adolescent with Intracranial Hypertension and Visual Impairment: A Case Report

2021 ◽  
Vol 13 (1) ◽  
pp. 233-238
Author(s):  
Seyed Mohammad Mousavi Mirzaei ◽  
Zahra Ahmadi
Keyword(s):  
Visual Impairment ◽  
Intracranial Hypertension ◽  
Aseptic Meningitis ◽  
Rare Complication ◽  
Clinical Signs ◽  
Male Adolescent ◽  
Drug Induced ◽  
Blurred Vision ◽  
Inflammatory Drugs

Drug-induced aseptic meningitis (DIAM) is a rare complication of certain drugs, most commonly reported with ibuprofen use. The present study reports on a male adolescent with intracranial hypertension and visual impairment accompanied by DIAM. We present a 16-year-old male patient who after ibuprofen consumption displayed headache, fever, photophobia, and blurred vision following heavy exercises. Examination of cerebrospinal fluid showed a mononuclear pleocytosis and an increase in protein concentration. Other examinations had normal results. The development of common clinical signs following ibuprofen use reflected DIAM. The patient’s vision was found to improve with supportive care and stopping of the drug during follow-up. Given the widespread use of nonsteroidal anti-inflammatory drugs and the fact that these drugs are the most common cause of DIAM, the probability of occurrence of this event should be always kept in mind, and screening for autoimmune diseases in these patients is of great importance.

scholarly journals Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Salem Agabawi
Keyword(s):  
Supportive Care ◽  
Aseptic Meningitis ◽  
Antimicrobial Agents ◽  
Medical Condition ◽  
Care Facility ◽  
Health Care Facility ◽  
Early Recovery ◽  
Drug Induced ◽  
Rare Presentation ◽  
One Year

Drug-induced aseptic meningitis is a rare medical condition with trimethoprim-sulfamethoxazole being one of the most common antimicrobial agents associated with it. Here, I report a case of a 56-year-old male who presented to a health care facility with shock and meningitis-like syndrome in two occasions, one year apart following an exposure to trimethoprim-sulfamethoxazole for treatment of skin/soft tissue infection. Investigations did not reveal an infectious etiology in the two presentations. The patient improved with supportive care and withdrawal of the offending agent. In the two admissions, the patient improved following stopping the offending drug in addition to supportive care. The diagnosis of trimethoprim-sulfamethoxazole-induced aseptic meningitis was the most likely explanation for this case. Trimethoprim-sulfamethoxazole-induced aseptic meningitis is rare although it is a life-threatening side effect of TMP/SMX; therefore, the clinicians should keep the diagnosis of drug-induced aseptic meningitis in the differential diagnosis of aseptic meningitis in the appropriate clinical setting as early withdrawal of the culprit drug and supportive measurements will lead to early recovery.

A Rare Case of Levetiracetam and Drug‐Induced Idiopathic Aseptic Meningitis in a Pediatric Patient

2018 ◽  
Vol 39 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Danielle McDonald ◽  
Richard Sultan ◽  
Anusha Viswanathan ◽  
Anita Siu
Keyword(s):  
Pediatric Patient ◽  
Aseptic Meningitis ◽  
Rare Case ◽  
Drug Induced

Drug-induced aseptic meningitis: A possible T-cell–mediated hypersensitivity

2018 ◽  
Vol 6 (4) ◽  
pp. 1409-1411 ◽  
Author(s):  
Julie Castagna ◽  
Audrey Nosbaum ◽  
Thierry Vial ◽  
Aurore Rozieres ◽  
Florence Hacard ◽  
...  
Keyword(s):  
T Cell ◽  
Aseptic Meningitis ◽  
Drug Induced

Drug-induced aseptic meningitis

2000 ◽  
Vol 205 ◽  
pp. 783-786 ◽  
Author(s):  
W. A. C. Sewell ◽  
S. Jolles
Keyword(s):  
Aseptic Meningitis ◽  
Drug Induced

Apport des tests in vitro dans deux cas de drug-induced aseptic meningitis (DIAM) par hypersensibilité retardée allergique à l’amoxicilline

2017 ◽  
Vol 57 (3) ◽  
pp. 251-252
Author(s):  
J. Castagna ◽  
A. Nosbaum ◽  
F. Hacard ◽  
C. Moch ◽  
A. Rozières ◽  
...  
Keyword(s):  
Aseptic Meningitis ◽  
Drug Induced

scholarly journals The Challenge of Drug-Induced Aseptic Meningitis Revisited

2014 ◽  
Vol 174 (9) ◽  
pp. 1511 ◽  
Author(s):  
German Morís ◽  
Juan Carlos Garcia-Monco
Keyword(s):  
Aseptic Meningitis ◽  
Drug Induced
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