scholarly journals Vitamin C as well as β-carotene attenuates experimental liver fibrosis after intoxication with carbon tetrachloride in rats

2012 ◽  
Vol 6 (2) ◽  
Author(s):  
S Wamutu ◽  
S Francque ◽  
S Chatterjee ◽  
E Musisi ◽  
GW Muyombya ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Vitamin C ◽  
Experimental Liver ◽  
Β Carotene

β-carotene inhibits NF-κB and restrains diethylnitrosamine-induced hepatic inflammation in Wistar rats

2020 ◽  
pp. 1-10
Author(s):  
Uzma Latief ◽  
Riaz Ahmad
Keyword(s):  
Liver Fibrosis ◽  
Wistar Rats ◽  
Hepatic Inflammation ◽  
Tissue Sections ◽  
Plausible Mechanism ◽  
Biochemical Mechanisms ◽  
Experimental Liver ◽  
Picrosirius Red ◽  
Β Carotene

Abstract. β-Carotene exhibits antioxidant and hepatoprotective activities via a multitude of biochemical mechanisms. However, the action mechanism involved in antioxidant and anti-inflammatory effects of this carotene in chronic liver diseases is not fully understood. In the present investigation, we have attempted to outline a plausible mechanism of β-carotene action against liver fibrosis in albino Wistar rats. To induce hepatic fibrosis, diethylnitrosamine (DEN) was administered in experimental rats for two weeks. DEN treated rats were divided into four groups, wherein each group comprised of five rats. β-Carotene supplement attenuated DEN-induced elevation in LFT markers (P < 0.05); averted depletion of glycogen (24%, P < 0.05) and, increased nitrite (P < 0.05), hydroxyproline (~67%, P < 0.05) and collagen levels (~65%, P < 0.05). Confocal microscopy of tissue sections stained with picrosirius red revealed accrued collagen in DEN-administered group, which was found to be reduced by β-carotene supplementation. Furthermore, β-carotene decreased the expression of iNOS/NOS-2 and NF-κB, as revealed by immunohistochemistry and Western immunoblotting. Collectively, these results demonstrate that β-carotene mitigates experimental liver fibrosis via inhibition of iNOS and NF-κB in-vivo. Thus, β-carotene may be suggested as a possible nutraceutical to curb experimental liver fibrosis.

scholarly journals Clinical Relevance of Vitamins and Carotenoids With Liver Steatosis and Fibrosis Detected by Transient Elastography in Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaohui Liu ◽  
Hong Shen ◽  
Mingfeng Chen ◽  
Jun Shao
Keyword(s):  
Liver Fibrosis ◽  
Linear Regression ◽  
Vitamin C ◽  
Vitamin B12 ◽  
Clinical Relevance ◽  
Transient Elastography ◽  
Liver Steatosis ◽  
Serum Vitamin ◽  
Non Linear ◽  
Β Carotene

Background: Vitamins and carotenoids may be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Previously related publications mainly focused on vitamin D and vitamin E, and studies on other vitamins and carotenoids and NAFLD are scarce.Methods: This study aimed to explore the clinical relevance of vitamin A, B vitamins (vitamin B1, vitamin B2, niacin, vitamin B6, folate, vitamin B12, and choline), vitamin C and carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein + zeaxanthin) with liver steatosis and fibrosis in the 2017–2018 NHANES (N = 4,352). Liver steatosis and fibrosis were detected by transient elastography. Logistic regression, linear regression and restricted cubic splines were adopted to explore the non-linear dose-response relationships.Results: Higher intakes of vitamin C [0.68 (0.50–0.93)] and β-carotene [0.71 (0.54–0.93)] were inversely associated with liver steatosis. Higher levels of serum vitamin C [0.45 (0.32–0.62)] were inversely associated with liver fibrosis, while higher intakes of choline [1.43 (1.04–1.98)] and α-carotene [1.67 (1.01–2.74)] were positively associated with liver fibrosis. In addition, marginally inverse association between lutein + zeaxanthin and liver steatosis and positive association between vitamin B12 and liver fibrosis were found. In linear regression, the above-mentioned associations between vitamin C, β-carotene, and lutein + zeaxanthin and liver steatosis, and serum vitamin C, choline, α-carotene, and vitamin B12 and liver fibrosis were also found. The above-mentioned associations were mainly linear, while the relationship between β-carotene and liver steatosis might be non-linear.Conclusion: Vitamin C, α-carotene, β-carotene, lutein + zeaxanthin, choline and vitamin B12 may be associated with liver steatosis and fibrosis.

TNF-α and leptin in experimental liver fibrosis models induced by carbon tetrachloride and by common bile duct ligation

2004 ◽  
Vol 22 (6) ◽  
pp. 359-363 ◽  
Author(s):  
İbrahim Halil Bahçecıoğlu ◽  
Mehmet Yalniz ◽  
Hüseyin Ataseven ◽  
Nurullah Bülbüller ◽  
Muzaffer Keçecı ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Liver Fibrosis ◽  
Common Bile Duct ◽  
Bile Duct Ligation ◽  
Common Bile Duct Ligation ◽  
Duct Ligation ◽  
Tnf Α ◽  
Experimental Liver

Protective effect of mixture of Aloe and Silybum on carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
YJ Moon ◽  
WC Lee ◽  
SJ Kim ◽  
ST Oh ◽  
EJ Shin ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Protective Effect
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