scholarly journals Predictors for tuberculosis co-infection in people living with HIV/AIDS

2021 ◽  
Vol 21 (3) ◽  
pp. 995-1002
Author(s):  
Esra Zerdali ◽  
İnci Yılmaz Nakir ◽  
Serkan Sürme ◽  
Uğurcan Sayılı ◽  
Mustafa Yıldırım
Keyword(s):  
Viral Load ◽  
Lymphocyte Count ◽  
People Living With Hiv ◽  
Characteristic Analysis ◽  
Cell Counts ◽  
Tertiary Teaching ◽  
Cd4 Lymphocyte Count ◽  
Cd4 Lymphocyte ◽  
Living With Hiv ◽  
Hiv Aids

Background/aim: Tuberculosis (TB) is one of the most common chronic infectious conditions causing mortality and se- vere outcomes, particularly in people living with HIV/AIDS (PLWHA). In this study, we aimed to determine the prevalence and predictors of TB among PLWHA. Materials and methods: We conducted a retrospective and single-center study of adults (≥18 years) PLWHA registered at our tertiary teaching and research hospital between 2000 and 2016. Results: A total of 711 PLWHA were included. Of whom, 633 (89.0%) were male. Mean age was 36.53 ±11.55 years (range, 17-79). Thirty-eight (5.3%) patients were diagnosed with active TB. TB development was associated with low CD4+ lymphocyte count (p<0.001), high viral load (p=0.040) and alcohol consumption (p=0.004) but no association with age (p=0.392), gender (p=0.928) and duration since anti-retroviral therapy initiation (p=0.788) was found. Also, a receiver operating characteristic analysis showed that the area under the curves of CD4+ lymphocyte count as a predictor for TB development in PLWHA was 0.717 (p<0.001). Conclusion: There are still clinical challenges to predict TB diagnosis. However, CD4+ lymphocyte count and viral load may be considered as valuable predictors for TB development. Also, community strategies to reduce harmful effect of alco- hol use should be developed. Keywords: Tuberculosis; HIV viral load; CD4 cell counts.

scholarly journals Evaluation of laboratory markers of progression of HIV disease to death

2011 ◽  
Vol 44 (6) ◽  
pp. 657-660 ◽  
Author(s):  
Graça Maria de Castro Viana ◽  
Maria do Desterro Soares Brandão Nascimento ◽  
Aila de Menezes Ferreira ◽  
Érica Milena Fernandes Rabelo ◽  
João Arnaud Diniz Neto ◽  
...  
Keyword(s):  
Viral Load ◽  
Hiv Disease ◽  
Significant Relation ◽  
Chi Square ◽  
Laboratory Markers ◽  
Cd4 Lymphocyte Count ◽  
Chi Square Test ◽  
Cd4 Lymphocyte ◽  
Hiv Aids

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

Outcomes by sex following treatment initiation with darunavir/cobicistat in a large Spanish cohort of the CODAR study (GeSIDA 9316)

2019 ◽  
Vol 74 (10) ◽  
pp. 3044-3048
Author(s):  
M J Pérez Elías ◽  
B Alejos ◽  
M J Vivancos ◽  
E Ribera ◽  
M J Galindo ◽  
...  
Keyword(s):  
Viral Load ◽  
Lymphocyte Count ◽  
Ethics Committees ◽  
Hiv Viral Load ◽  
Women Living With Hiv ◽  
Load Response ◽  
Cd4 Lymphocyte Count ◽  
Previous Regimen ◽  
Cd4 Lymphocyte ◽  
Viral Load Response

Abstract Background Few women have been included in darunavir/cobicistat clinical development studies, and hardly any of them were antiretroviral experienced or treated with anything other than triple-based therapies. Objectives Our aim was to increase our knowledge about women living with HIV undergoing darunavir/cobicistat-based regimens. Methods A multicentre (21 hospitals), retrospective study including a centrally selected random sample of HIV-1 patients starting a darunavir/cobicistat-based regimen from June 2014 to March 2017 was planned. Baseline characteristics, 24 and 48 week viral load response (<50 copies/mL), CD4+ lymphocyte count increase, time to change darunavir/cobicistat and adverse event occurrence were all compared by sex. The study was approved by each of the 21 ethics committees, and patients signed informed consent. Results Out of 761 participants, 193 were women. Similar characteristics were found for both sexes, except that the women had a longer duration of HIV infection (P = 0.001), and were less frequently pre-treated with darunavir/cobicistat in their previous regimen (P = 0.02). The main reason for using a darunavir/cobicistat-based regimen was simplification, without differences by sex, while monotherapy seems to be more frequently prescribed in women than in men (P = 0.067). The main outcomes, HIV viral load response, CD4+ lymphocyte count increase at 24 or 48 weeks, occurrence of adverse events, main reasons for changing and time to the modify darunavir/cobicistat regimen, did not show differences between the sexes. Conclusions No sex disparities were found in the main study outcomes. These results support the use of a darunavir/cobicistat-based regimen in long-term pre-treated women. Clinical Trial.gov No. NCT03042390.

scholarly journals Knowledge of PEP and PrEP among people living with HIV/aids in Brazil

2021 ◽  
Author(s):  
Laelson Rochelle Milanês Sousa ◽  
Henrique Ciabotti Elias ◽  
Nilo Martinez Fernandes ◽  
Elucir Gir ◽  
Renata Karina Reis
Keyword(s):  
Viral Load ◽  
Secondary Prevention ◽  
Educational Interventions ◽  
Sexual Partners ◽  
Post Exposure Prophylaxis ◽  
People Living With Hiv ◽  
Factors Associated ◽  
Exposure Prophylaxis ◽  
Living With Hiv ◽  
Hiv Aids

Abstract Background: Pre-Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP) are key to preventing sexual transmission of HIV, whose sexual partners are at high risk of acquiring HIV. We aimed to determine the factors associated with PrEP and PEP's knowledge as secondary prevention among people living with HIV/AIDS.Method: Cross-sectional analytical study carried out among people living with HIV/AIDS treated at five specialized services in the city of Ribeirão Preto, São Paulo, Brazil. Data were collected from July 2016 to July 2017. Individual interviews were conducted. We used multivariable logistic regression to determine factors associated with knowing PrEP and PEP. Results: Of the 397 participants, 140 (35.26%) were heterosexual women aged 40 to 49 years (36.2%).Participants with less than 11 years of study (adjusted odds: 0.29; 95% CI: 0.13-0.60); who did not have a low viral load or did not know their viral load (adjusted odds: 0.29; 95% CI: 0.09-0.83) and those with casual partners (adjusted odds: 0.29; 95% CI: 0.09- 0.83) were less likely to know about the PrEP. MSM (adjusted odds: 2.88; 95% CI: 1.59-5.3) and those who used alcohol during sexual intercourse (adjusted odds: 1.7; 95% CI: 1.0-2.8) were more likely to know about the PEP.Conclusions: The knowledge about PEP and PrEP is low in Brazil. This may undermine secondary prevention efforts. Educational interventions to raise awareness of these prevention methods are needed among people living with HIV and who have HIV-negative sexual partners.

scholarly journals Burden of Talaromyces marneffei infection in people living with HIV/AIDS in Asia during ART era: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Yuanyuan Qin ◽  
Xiaojie Huang ◽  
Hui Chen ◽  
Xinchao Liu ◽  
Yao Li ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Lower Latitude ◽  
People Living With Hiv ◽  
Dimorphic Fungus ◽  
Talaromyces Marneffei ◽  
Cell Counts ◽  
Pooled Prevalence ◽  
Increased Risk ◽  
Living With Hiv ◽  
Hiv Aids

Abstract Background： Talaromyces marneffei (TM) is a dimorphic fungus mainly prevalent in Southeast Asian countries, which often causes disseminated life-threatening infection. TM infection often occurs in HIV/AIDS patients even in the antiretroviral therapy (ART) era. However, there has as yet, not been a systematic analysis of the prevalence of TM infection in HIV-infected populations in AsiaMethods：In this study, we searched Pubmed, Embase, Web of Science, CNKI, and WanFang from inception to 21 November 2018 for studies reporting TM infection in people living with HIV/AIDS (PLWHA). Our meta-analysis included studies investigating the prevalence of TM infection in PLWHA. Reviews, duplicate studies, and animal studies were excluded. A random effects model was used to estimate pooled prevalence, and meta-regression analysis was conducted to explore potential factors for heterogeneity.Results： 159,064 patients with HIV infection in 33 eligible studies were included in our meta-analysis. The pooled prevalence of TM infection in PLWHA was 3.6%. Vietnam had the highest prevalence (6.4%), followed by Thailand (3.9%), China (3.3%), India (3.2%) and Malaysia (2.1%). In China, TM infection was most prevalent in South China (15.0%), while the burden in Southwest China was not very heavy (0.3%). CD4+ T-cell counts below 200cells/mm3 contributed to the increased risk of TM infection in PLWHA (OR 12.68, 95%CI: 9.58-16.77). However, access to ART did not significantly decrease the risk of TM infection in PLWHA.Conclusions： The burden of TM infection in Asia is heavy, and varies from region to region. PLWHA in lower latitude areas are more likely to suffer from TM infection. Optimization of diagnostic tools and universal screening for TM in vulnerable people to ensure early case detection and prompt antifungal treatment should be considered.

scholarly journals Factors associated with the isolation of Candida Spp. from the oral microbiota of people living with HIV

2020 ◽  
Vol 8 (3) ◽  
pp. 22
Author(s):  
Antônio Uelton Araújo Da Silva ◽  
Gabriela Cruz Da Silva ◽  
Érika Helena Salles De Brito ◽  
Thiago Moura De Araújo ◽  
Maria Aparecida Alves De Oliveira Serra ◽  
...  
Keyword(s):  
Viral Load ◽  
Oral Cavity ◽  
Virulence Factors ◽  
Saliva Sample ◽  
Smoking Habits ◽  
Oral Microbiota ◽  
People Living With Hiv ◽  
Oral Candida ◽  
Living With Hiv ◽  
Hiv Aids

This study aimed to analyze the association between the isolation of Candida species in the oral cavity and the clinical and virulence factors of people living with Human immunodeficiency virus (HIV). This cross-sectional study, comprising 106 people living with HIV who were evaluated in an HIV-AIDS outpatient clinic in Fortaleza, Northeast of Brazil, data collection were conducted during August and November 2018. A saliva sample was also collected to isolate Candida. The virulence factors of extracellular and hemolytic phospholipase activities in isolated Candida strains were analyzed. The prevalence of oral Candida was 40.6%, and the presence of oral Candida was associated with smoking habits (p = .005), daily smoking (p = .026), low weight (p = .030), history of hospitalization (p = .014), TCD4 lymphocyte count < 200 cells/mm3 (p = .018), and detectable viral load (p = .005). The multivariate analysis revealed that the variables smoking habits (p = .008), viral load (p = .011), and body mass index (p = .011) were associated with the presence of oral Candida. Strong hemolytic and phospholipase activities were, respectively, identified in 74.4% and 72% of the isolated strains, mainly Candida albicans. As a main conclusion, the isolation of Candida from the oral cavity in people living with HIV/AIDS, has a strong association with the use of tobacco, even under anappropriate treatment.

scholarly journals Viral load as a risk factor of reverse transcriptase inhibitor drug resistance mutation in antiretroviral-treated people living with HIV/AIDS

2021 ◽  
Vol 40 (3) ◽  
pp. 243-253
Author(s):  
Hotma Martogi Lorensi Hutapea ◽  
Tri Nury Kridaningsih ◽  
Khoirul Huda Prasetyo ◽  
Milton Boaheng Antwi
Keyword(s):  
Drug Resistance ◽  
Logistic Regression ◽  
Viral Load ◽  
Reverse Transcriptase ◽  
Cd4 Count ◽  
People Living With Hiv ◽  
Multiple Logistic Regression ◽  
Living With Hiv ◽  
Hiv 1 ◽  
Hiv Aids

Background The human immunodeficiency virus type 1 (HIV-1) is a major contagion faced by the population of Indonesia. The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). The aim of this study was to determine the association between CD4 count, CD4 count changes, viral load, adherence to therapy, and therapy history in the presence of DRM in people living with HIV/AIDS (PLWHA). MethodsThis was a cross-sectional study involving 269 adults who underwent antiretroviral (ARV) therapy for at least 6 months. The frequencies of DRM and polymorphisms were measured by partial amplification of the reverse transcriptase (RT) gene using RT-nested PCR on samples with viral loads of >1000 copies/mL. Sequencing was performed using the Sanger method, and edited by BioEdit. The edited sequences were submitted to http://hivdb.stanford.edu for DRM determination. Respondents’ medical data, CD4 count, viral load, and DRM were analyzed by simple and multiple logistic regression. ResultsThe multiple logistic regression analysis showed a significant association of CD4 count (aOR=12.47; 95% CI: 1.45 -107.39; p=0.023) and viral load at the time of study (aOR=29.56; 95% CI: 3.47-251.52; p=0.002) with the presence of DRM in respondents. ARV substitution history was not associated with the presence of DRM. There were 17 respondents (6.3%) carrying HIV-1 DRM, with M184V/I (11 sequences) as the most frequent pattern of NRTI resistance, and K103 (9 sequences) as that of NNRTI resistance. ConclusionThis study demonstrated that viral load at the time of the study was the most influential determinant factor for the presence of DRM in PLWHA.

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