scholarly journals Seroprevalence of hepatitis B and C infection among the HIV-positive population in Abuja, Nigeria

2013 ◽  
Vol 12 (3) ◽  
Author(s):  
A Tremeau-Bravard ◽  
IC Ogbukagu ◽  
CJ Ticao ◽  
JJ Abubakar
Author(s):  
Sonu Suman

Background: Human immunodeficiency virus (HIV) positive population is at higher risk of getting infected with hepatitis B virus (HBV) or hepatitis C virus (HCV) or both. Co-infection with HBV/HCV may possibly complicate the clinical course of HIV in infected patients. Aim and objectives of the study were intended to determine clinical, haematological and biochemical profile of HIV patients co infected with hepatitis B and/or C.Methods: All consecutive patients presented with HIV infection who were coinfected with either Hepatitis B, C or both presenting to immunodeficiency or Gastroenterology OPD Base Hospital Delhi, were included in the study. It was a prospective, observational study.Results: HIV impacts the progression of HCV and increases the likelihood of subsequent liver damage as it is apparent in study by significant raised liver enzymes and hypoalbuminemia in HIV-HCV co infection compare to HIV–HBV.  Conclusions: These coinfections are more common in younger and lesser educated people. Biochemical parameters could serve as pointers for early detection of liver disease as result of hepatitis co infections in HIV patients. Prompt diagnosis of HCV and HBV co-infection in HIV patients has both individual and public health benefits.


2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Oluyinka Oladele Opaleye ◽  
Adeolu Sunday Oluremi ◽  
Adetona Babatunde Atiba ◽  
Moses Olubusuyi Adewumi ◽  
Olatunji Victor Mabayoje ◽  
...  

HIV has been known to interfere with the natural history of hepatitis B virus (HBV) infection. In this study we investigate the prevalence of occult hepatitis B virus infection (OBI) among HIV-infected individuals in Nigeria. Overall, 1200 archived HIV positive samples were screened for detectable HBsAg using rapid technique, in Ikole Ekiti Specialist Hospital. The HBsAg negative samples were tested for HBsAg, anti-HBc, and anti-HCV by ELISA. Polymerase chain reaction was used for HBV DNA amplification and CD4 counts were analyzed by cytometry. Nine hundred and eighty of the HIV samples were HBsAg negative. HBV DNA was detected in 21/188 (11.2%) of patients without detectable HBsAg. CD4 count for the patients ranged from 2 to 2,140 cells/μL of blood (mean = 490 cells/μL of blood). HCV coinfection was detected only in 3/188 (1.6%) of the HIV-infected patients (P>0.05). Twenty-eight (29.2%) of the 96 HIV samples screened were positive for anti-HBc. Averagely the HBV viral load was <50 copies/mL in the OBI samples examined by quantitative PCR. The prevalence of OBI was significantly high among HIV-infected patients. These findings highlight the significance of nucleic acid testing in HBV diagnosis in HIV patients.


2003 ◽  
Vol 17 (9) ◽  
pp. 439-442 ◽  
Author(s):  
Maria Ristig ◽  
Henning Drechsler ◽  
Jeffrey Crippin ◽  
Mauricio Lisker-Melman ◽  
Pablo Tebas

Author(s):  
Zoltan Lukacs ◽  
Alexandra Dietrich ◽  
Rainer Ganschow ◽  
Alfried Kohlschütter ◽  
Rudolf Kruithof

AbstractHIV in particular, as well as hepatitis B and C, present a burden on healthcare systems worldwide. Early detection of these diseases may prevent further infections and improve the outcome for patients. In particular, transmission of HIV from mother to child can be significantly reduced when preventive measures are taken before birth. We have developed and optimized a method for the simultaneous detection of HIV 1 and hepatitis B and C from dried blood specimensusing the Luminex multi-analyte profiling technology (LabMap). Dried blood spots provide a convenient method for mailing, analysis and storage of samples. Specimens from known HIV-positive children (n=46) as well as hepatitis B- (n=8) and hepatitis C-positive patients (n=7) tested positive in our assay. Storage for up to 10years did not interfere with the test in the case of HIV-positive patients. Results for five different antibodies and one antigen were obtained in approximately 80seconds. Furthermore, antibody levels in infants of HIV-positive mothers were monitored over a period of 1year. Antibodies were no longer detectable after 260–360days, which compared well with results independently obtained by ELISA and Western blot analysis. We demonstrated the feasibility of the simultaneous detection of infectious diseases from dried blood. Our novel method also provides a convenient tool for monitoring children from HIV-positive mothers and for possible screening efforts.


2006 ◽  
Vol 20 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Alexander R. Ende ◽  
Vincent Lo Re ◽  
Mark J. DiNubile ◽  
Karam Mounzer

Author(s):  
Tasilo Kamenya ◽  
Damian Jeremia Dami ◽  
James Samwel Ngocho ◽  
Rune Nathanael Philemon ◽  
Michael Johnson Mahande ◽  
...  

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