scholarly journals Occult Hepatitis B Virus Infection among HIV Positive Patients in Nigeria

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Oluyinka Oladele Opaleye ◽  
Adeolu Sunday Oluremi ◽  
Adetona Babatunde Atiba ◽  
Moses Olubusuyi Adewumi ◽  
Olatunji Victor Mabayoje ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hbv Dna ◽  
Hiv Positive ◽  
Hepatitis B Virus Infection ◽  
Occult Hepatitis ◽  
B Virus ◽  
Occult Hepatitis B ◽  
Detectable Hbsag

HIV has been known to interfere with the natural history of hepatitis B virus (HBV) infection. In this study we investigate the prevalence of occult hepatitis B virus infection (OBI) among HIV-infected individuals in Nigeria. Overall, 1200 archived HIV positive samples were screened for detectable HBsAg using rapid technique, in Ikole Ekiti Specialist Hospital. The HBsAg negative samples were tested for HBsAg, anti-HBc, and anti-HCV by ELISA. Polymerase chain reaction was used for HBV DNA amplification and CD4 counts were analyzed by cytometry. Nine hundred and eighty of the HIV samples were HBsAg negative. HBV DNA was detected in 21/188 (11.2%) of patients without detectable HBsAg. CD4 count for the patients ranged from 2 to 2,140 cells/μL of blood (mean = 490 cells/μL of blood). HCV coinfection was detected only in 3/188 (1.6%) of the HIV-infected patients (P>0.05). Twenty-eight (29.2%) of the 96 HIV samples screened were positive for anti-HBc. Averagely the HBV viral load was <50 copies/mL in the OBI samples examined by quantitative PCR. The prevalence of OBI was significantly high among HIV-infected patients. These findings highlight the significance of nucleic acid testing in HBV diagnosis in HIV patients.

HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg

2016 ◽  
Vol 89 (2) ◽  
pp. 246-256 ◽  
Author(s):  
Ahmadreza Sadeghi ◽  
Elham Shirvani-Dastgerdi ◽  
Frank Tacke ◽  
Eray Yagmur ◽  
Vahdat Poortahmasebi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Conformational Changes ◽  
Hiv Positive ◽  
Hepatitis B Virus Infection ◽  
Occult Hepatitis ◽  
B Virus ◽  
Occult Hepatitis B

scholarly journals Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179035 ◽  
Author(s):  
Debraj Saha ◽  
Ananya Pal ◽  
Neelakshi Sarkar ◽  
Dipanwita Das ◽  
Jason T. Blackard ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hiv Positive ◽  
Hepatitis B Virus Infection ◽  
Eastern India ◽  
Occult Hepatitis ◽  
B Virus ◽  
Occult Hepatitis B ◽  
Tertiary Healthcare

scholarly journals Characterization of occult hepatitis B virus infection among HIV positive patients in Cameroon

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
George Gachara ◽  
Tshifhiwa Magoro ◽  
Lufuno Mavhandu ◽  
Emmaculate Lum ◽  
Helen K. Kimbi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hiv Positive ◽  
Hepatitis B Virus Infection ◽  
Occult Hepatitis ◽  
B Virus ◽  
Occult Hepatitis B

scholarly journals Identification of mutations in the S gene of hepatitis B virus in HIV positive Mexican patients with occult hepatitis B virus infection

2020 ◽  
Vol 19 (5) ◽  
pp. 507-515
Author(s):  
Karina Enriquez-Navarro ◽  
Angelica Maldonado-Rodriguez ◽  
Othon Rojas-Montes ◽  
Rocio Torres-Ibarra ◽  
Leticia Bucio-Ortiz ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hiv Positive ◽  
Hepatitis B Virus Infection ◽  
Occult Hepatitis ◽  
S Gene ◽  
B Virus ◽  
Occult Hepatitis B ◽  
Mexican Patients

scholarly journals Occult hepatitis B virus infection in hemodialysis patients in Recife, State of Pernambuco, Brazil

2012 ◽  
Vol 45 (5) ◽  
pp. 558-562 ◽  
Author(s):  
Ana Cecília Cavalcanti de Albuquerque ◽  
Maria Rosângela Cunha Duarte Coelho ◽  
Marcílio Figueiredo Lemos ◽  
Regina Célia Moreira
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hemodialysis Patients ◽  
Hbv Dna ◽  
Hepatitis B Virus Infection ◽  
Occult Infection ◽  
Occult Hepatitis ◽  
B Virus ◽  
Occult Hepatitis B

INTRODUCTION: Persistence of the hepatitis B virus (HBV) genome in individuals negative for the HBV surface antigen (HBsAg) reflects occult infection. The aim of this study was to identify occult HBV infection among hemodialysis patients at 5 clinics in Recife, State of Pernambuco, Brazil, between August 2006 and August 2007. METHODS: Serum samples underwent enzyme-linked immunosorbent assay to investigate total antibodies against HBcAg (anti-HBc), HBsAg, and antibodies against HBsAg (anti-HBs). Samples that were HBsAg-negative were tested for total anti-HBc, and those that were positive for total anti-HBc were tested for anti-HBs. HBV DNA was investigated with an in-house PCR technique to identify samples positive for total anti-HBc. Subsequently, the samples positive for HBV DNA were sequenced to identify the genotype and mutations. RESULTS: The study population (n = 752) had a mean age of 50 15.1 years and included both sexes. All samples analyzed were negative for HBsAg. The seroprevalence of total anti-HBc was 26.7% (201/752), while that of anti-HBs was 67.2% (135/201). Total anti-HBc alone was detected in 5.7% of the patients. Occult infection was found in 1.5%, comprising genotypes A (33.3%, 1/3) and D (66.7%, 2/3). No mutations were found. CONCLUSIONS: The study detected occult hepatitis B virus infection in hemodialysis patients. Molecular studies on HBV are of fundamental importance because they identify patients that had been considered virus-negative but who, in reality, host the virus and have the ability to transmit it to other patients and staff.

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