Systemic Administration of γ-Hydroxybutyric Acid in Adolescent Rat Impairs Contextual Fear Conditioning, But Not Cued Conditioning

2014 ◽  
Vol 3 ◽  
pp. 1-8 ◽  
Author(s):  
Ratna Sircar ◽  
Keita Ishiwari
Keyword(s):  
Fear Conditioning ◽  
Systemic Administration ◽  
Contextual Fear Conditioning ◽  
Hydroxybutyric Acid ◽  
Contextual Fear

scholarly journals The role of carbonic anhydrases in extinction of contextual fear memory

2020 ◽  
Vol 117 (27) ◽  
pp. 16000-16008 ◽  
Author(s):  
Scheila Daiane Schmidt ◽  
Alessia Costa ◽  
Barbara Rani ◽  
Eduarda Godfried Nachtigall ◽  
Maria Beatrice Passani ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Fear Conditioning ◽  
Fear Extinction ◽  
Systemic Administration ◽  
Contextual Fear Conditioning ◽  
Ventromedial Prefrontal Cortex ◽  
Carbonic Anhydrases ◽  
Contextual Fear ◽  
Extinction Memory ◽  
The Brain

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in mammals with 16 isoforms that differ in terms of catalytic activity as well as cellular and tissue distribution. CAs catalyze the conversion of CO2to bicarbonate and protons and are involved in various physiological processes, including learning and memory. Here we report that the integrity of CA activity in the brain is necessary for the consolidation of fear extinction memory. We found that systemic administration of acetazolamide, a CA inhibitor, immediately after the extinction session dose-dependently impaired the consolidation of fear extinction memory of rats trained in contextual fear conditioning.d-phenylalanine, a CA activator, displayed an opposite action, whereas C18, a membrane-impermeable CA inhibitor that is unable to reach the brain tissue, had no effect. Simultaneous administration of acetazolamide fully prevented the procognitive effects ofd-phenylalanine. Whereasd-phenylalanine potentiated extinction, acetazolamide impaired extinction also when infused locally into the ventromedial prefrontal cortex, basolateral amygdala, or hippocampal CA1 region. No effects were observed when acetazolamide ord-phenylalanine was infused locally into the substantia nigra pars compacta. Moreover, systemic administration of acetazolamide immediately after the extinction training session modulated c-Fos expression on a retention test in the ventromedial prefrontal cortex of rats trained in contextual fear conditioning. These findings reveal that the engagement of CAs in some brain regions is essential for providing the brain with the resilience necessary to ensure the consolidation of extinction of emotionally salient events.

Role of dorsal and ventral hippocampal muscarinic receptor activity in acquisition and retention of contextual fear conditioning.

2020 ◽  
Vol 134 (5) ◽  
pp. 460-470
Author(s):  
Claudia C. Pinizzotto ◽  
Nicholas A. Heroux ◽  
Colin J. Horgan ◽  
Mark E. Stanton
Keyword(s):  
Fear Conditioning ◽  
Muscarinic Receptor ◽  
Contextual Fear Conditioning ◽  
Receptor Activity ◽  
Contextual Fear

scholarly journals Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 24 (2) ◽  
pp. 204-213 ◽  
Author(s):  
W. Bailey Glen ◽  
Bryant Horowitz ◽  
Gregory C. Carlson ◽  
Tyrone D. Cannon ◽  
Konrad Talbot ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear

Hippocampal NMDA receptor blockade impairs CREB phosphorylation in amygdala after contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 23 (7) ◽  
pp. 545-551 ◽  
Author(s):  
Cesar Augusto de Oliveira Coelho ◽  
Tatiana Lima Ferreira ◽  
Juliana Carlota Kramer Soares ◽  
Maria Gabriela Menezes Oliveira
Keyword(s):  
Nmda Receptor ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Receptor Blockade ◽  
Creb Phosphorylation ◽  
Contextual Fear ◽  
Nmda Receptor Blockade

scholarly journals Hippocampal but not amygdalar volume affects contextual fear conditioning in humans

2011 ◽  
Vol 33 (2) ◽  
pp. 478-488 ◽  
Author(s):  
Sebastian T. Pohlack ◽  
Frauke Nees ◽  
Claudia Liebscher ◽  
Raffaele Cacciaglia ◽  
Slawomira J. Diener ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Amygdalar Volume
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