scholarly journals Dysbindin-1 loss compromises NMDAR-dependent synaptic plasticity and contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 24 (2) ◽  
pp. 204-213 ◽  
Author(s):  
W. Bailey Glen ◽  
Bryant Horowitz ◽  
Gregory C. Carlson ◽  
Tyrone D. Cannon ◽  
Konrad Talbot ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear

scholarly journals Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal  -Amyloid Fragment

2014 ◽  
Vol 34 (43) ◽  
pp. 14210-14218 ◽  
Author(s):  
J. L. M. Lawrence ◽  
M. Tong ◽  
N. Alfulaij ◽  
T. Sherrin ◽  
M. Contarino ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Contextual Fear

c-Jun N-terminal kinases in memory and synaptic plasticity

2011 ◽  
Vol 22 (4) ◽  
Author(s):  
Tessi Sherrin ◽  
Thomas Blank ◽  
Cedomir Todorovic
Keyword(s):  
Synaptic Plasticity ◽  
Fear Conditioning ◽  
Long Term Potentiation ◽  
Contextual Fear Conditioning ◽  
Contextual Fear ◽  
Term Potentiation ◽  
Stress Signal ◽  
Mitogen Activated Protein ◽  
Jnk Isoforms ◽  
Future Work

AbstractThe c-Jun N-terminal kinases (JNK) belong to the subfamily of mitogen-activated protein kinases (MAPK). JNK is an important signaling enzyme that is involved in many facets of cellular regulation including gene expression, cell proliferation and programmed cell death. Activation of JNK isoforms (JNK1, 2, and 3) is regarded as a molecular switch in stress signal transduction. The activation of JNK pathways is also critical for pathological death associated with neurodegenerative diseases. Considering that a variety of stressors activate JNK, it is surprising that the role of hippocampal JNK in memory and synaptic plasticity has not yet been systematically investigated. Here we summarize the emerging evidence for the functions of hippocampal JNK in memory and synaptic plasticity, including our recent demon­stration that JNK isoforms play critical roles in regulation of contextual fear conditioning under stressful and baseline conditions. We postulate that sustained activation of the hippocampal JNK2 and JNK3 pathways is involved in the initial stress response that ultimately leads to deficits in memory and long-term potentiation, whereas transient JNK1 activation regulates baseline contextual fear conditioning. Results obtained within the framework of our recent findings will be used for future work, which will differentiate mechanisms underlying beneficial short-term JNK action from prolonged JNK activation that may lead to memory deficits and neurodegeneration.

Role of dorsal and ventral hippocampal muscarinic receptor activity in acquisition and retention of contextual fear conditioning.

2020 ◽  
Vol 134 (5) ◽  
pp. 460-470
Author(s):  
Claudia C. Pinizzotto ◽  
Nicholas A. Heroux ◽  
Colin J. Horgan ◽  
Mark E. Stanton
Keyword(s):  
Fear Conditioning ◽  
Muscarinic Receptor ◽  
Contextual Fear Conditioning ◽  
Receptor Activity ◽  
Contextual Fear

Hippocampal NMDA receptor blockade impairs CREB phosphorylation in amygdala after contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 23 (7) ◽  
pp. 545-551 ◽  
Author(s):  
Cesar Augusto de Oliveira Coelho ◽  
Tatiana Lima Ferreira ◽  
Juliana Carlota Kramer Soares ◽  
Maria Gabriela Menezes Oliveira
Keyword(s):  
Nmda Receptor ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Receptor Blockade ◽  
Creb Phosphorylation ◽  
Contextual Fear ◽  
Nmda Receptor Blockade
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