scholarly journals Analysis of time trends in preemptive kidney transplantation and effect of pre-transplant dialysis duration on graft survival: a nationwide cohort study

2020 ◽  
Vol 34 (1) ◽  
pp. S42-S42
Author(s):  
Jeong-Hoon Lim ◽  
Sang-Ho Lee ◽  
Yu Ho Lee ◽  
Jung Pyo Lee ◽  
Jaeseok Yang ◽  
...  
Author(s):  
Clarisse Grèze ◽  
Bruno Pereira ◽  
Yves Boirie ◽  
Laurent Guy ◽  
Clémentine Millet ◽  
...  

Abstract Background The access of obese patients to kidney transplantation is limited despite several studies showing that obese transplant recipients had a better survival rate than those undergoing dialysis. The aim of this study was to compare patient and graft survival rates and post-renal transplant complications in obese patients and non-obese patients and to assess the effect of pre-transplant weight loss in obese patients on transplant outcomes. Methods We carried out a prospective cohort study using two French registries REIN and CRISTAL on 7 270 kidney transplant patients between 2008 and 2014 in France. We compared obese patients with non-obese patients and obese patients who lost more than 10% of weight before the transplant (Obese WL and Obese nWL). Results The mean BMI in our obese patients was 32 kg/m2. Graft survival was lower in obese patients than in non-obese patients (HR = 1.40, IC 95% [1.09; 1.78], P = 0.007) whereas patient survival was similar (HR = 0.94, IC 95% [0.73; 1.23], P = 0.66). Graft survival was significantly lower in Obese WL than in Obese nWL (HR = 2.17, CI 95% [1.02; 4.63], P = 0.045) whereas patient survival was similar in the two groups (HR = 0.79, IC 95% [0.35; 1.77], P = 0.56). Conclusion Grade I obesity does not seem to be a risk factor for excess mortality after kidney transplantation and should not be an obstacle to having access to a graft. Weight loss before a kidney transplant in this patients should not be essential for registration on waiting list.


2017 ◽  
Vol 31 (4) ◽  
pp. 408-423 ◽  
Author(s):  
Sophie Girerd ◽  
Nicolas Girerd ◽  
Kevin Duarte ◽  
Magali Giral ◽  
Christophe Legendre ◽  
...  

2016 ◽  
Vol 21 (6) ◽  
pp. 1105-1112 ◽  
Author(s):  
Masayoshi Okumi ◽  
◽  
Yasuyuki Sato ◽  
Kohei Unagami ◽  
Toshihito Hirai ◽  
...  

2020 ◽  
Vol 104 (S3) ◽  
pp. S469-S469
Author(s):  
Woo Yeong Park ◽  
Ohyun Kwon ◽  
Yaerim Kim ◽  
Jin Hyuk Paek ◽  
Kyubok Jin ◽  
...  

2015 ◽  
Vol 65 (1) ◽  
pp. 172-173 ◽  
Author(s):  
Rebecca A. Spicer ◽  
Philip A. Clayton ◽  
Steven J. McTaggart ◽  
Geoff Y. Zhang ◽  
Stephen I. Alexander

2015 ◽  
Vol 15 (9) ◽  
pp. 2378-2386 ◽  
Author(s):  
N. Krishnan ◽  
R. Higgins ◽  
A. Short ◽  
D. Zehnder ◽  
D. Pitcher ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3002
Author(s):  
Chieh-Li Yen ◽  
Pei-Chun Fan ◽  
George Kuo ◽  
Chao-Yu Chen ◽  
Ya-Lien Cheng ◽  
...  

Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Retrospective nationwide cohort study, from Taiwan’s National Health Insurance Research Database. Patients having undergone a first preemptive kidney transplantation between 2001 and 2017 were identified and divided into two groups according to the presence of sLPD treatment or not. The primary outcome was the time between the diagnosis of advanced CKD and transplantation. Secondary outcomes were post-transplantation adverse events. Results: A total of 245 patients who received their first preemptive kidney transplantation were identified from the nationwide database; 63 of them had been on an sLPD prior to transplantation (sLPD group). The duration between the day of advanced CKD diagnosis and the day of transplantation was significantly longer in the sLPD group compared with the non-sLPD group (median duration: 345 vs. 220 days, p = 0.001). The risk of post-transplantation adverse events did not differ between the two groups. Conclusions: Within the limits of its observational, retrospective design, this is the first study to suggest that nutritional management with sLPDs can safely delay the timing of preemptive kidney transplantation.


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