scholarly journals Rat model of heterotopic heart transplantation to investigate relevant donor heart harvesting method

2020 ◽  
Vol 34 (1) ◽  
pp. S177-S177
Author(s):  
Mukhammad Kayumov ◽  
Hwa-Jin Cho ◽  
Do-Wan Kim ◽  
Kyo-Seon Lee ◽  
In-Seok Jeong
Keyword(s):  
Heart Transplantation ◽  
Rat Model ◽  
Donor Heart ◽  
Heterotopic Heart Transplantation ◽  
Harvesting Method

Heterotopic heart transplantation: catheterization, endomyocardial biopsy, and coronary angiography of the donor heart

1994 ◽  
Vol 32 (1) ◽  
pp. 18-26
Author(s):  
Richard W. Lowry ◽  
Jamil N. Bitar ◽  
W. Carter Grinstead ◽  
James B. Young ◽  
George P. Noon ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Heart Transplantation ◽  
Endomyocardial Biopsy ◽  
Donor Heart ◽  
Heterotopic Heart Transplantation

scholarly journals Graft vasculopathy in a Wistar rat model of heterotopic heart transplantation depending on gender matching between donors and recipients

2018 ◽  
Vol 15 (3) ◽  
pp. 157-161
Author(s):  
Joanna E. Śliwka ◽  
Roman Przybylski ◽  
Anna Dołaszyńska-Żółkiewska ◽  
Adam Sokal ◽  
Mirosław Tyrpień ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Rat Model ◽  
Wistar Rat ◽  
Heterotopic Heart Transplantation ◽  
Graft Vasculopathy ◽  
Gender Matching

scholarly journals Evaluation of a Peritoneal-Generated Cardiac Patch in a Rat Model of Heterotopic Heart Transplantation

2009 ◽  
Vol 18 (3) ◽  
pp. 275-282 ◽  
Author(s):  
Gabriel Amir ◽  
Liron Miller ◽  
Michal Shachar ◽  
Micha S. Feinberg ◽  
Radka Holbova ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Rat Model ◽  
Heterotopic Heart Transplantation ◽  
Cardiac Patch

scholarly journals Comparison of hemodynamic and infarct-limiting effects of preservation solution based on Krebs–Henseleit buffer and HTK solution in the rat model of heterotopic heart transplantation

2019 ◽  
Vol 25 (1) ◽  
pp. 84-89 ◽  
Author(s):  
M. M. Galagudza ◽  
S. M. Minasian ◽  
Yu. V. Dmitriev ◽  
Ya. I. Poleshenko ◽  
P. Yu. Shubina ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Myocardial Damage ◽  
Left Ventricular ◽  
Ventricular Contractility ◽  
Donor Heart ◽  
Cardioplegic Solution ◽  
Preservation Solution ◽  
Heterotopic Heart Transplantation ◽  
Htk Solution ◽  
Krebs Henseleit Buffer

Objective. To compare the cardioprotective effcacy of a preservation solution based on Krebs–Henseleit buffer and HTK solution in the model of heterotopic heart transplantation in rat.Design and methods. A study was conducted on 12 Wistar rats. The animals were divided into groups depending on the preservation solution used: 1) Krebs–Henseleit buffer-based solution (n = 7), 2) HTK (n = 5). Each experiment consisted of collecting donor heart, preserving it with an appropriate cardioplegic solution, heterotopic transplantation into a recipient rat followed by explantation and evaluation of left ventricular contractility using the Langendorff model and histochemical assessment of the irreversible myocardial damage. Coronary blood flow in the donor heart was assessed in vivo using ultrasound doppler flowmetry. After 3 hours, the donor heart was explanted and connected to the Langendorff apparatus to assess left ventricular contractility, and the myocardium was subjected to histochemical staining with 1 % triphenyltetrazolium chloride for the assessment of the irreversible myocardial damage.Results. In the group of Krebs–Henseleit buffer-based cardioplegic solution, 7 experiments were performed. Myocardial infarct size was 3,5 ± 1,2%, the coronary flow rate was 4,5 ± 1,3 ml/min, and the developed left ventricular pressure of the donor heart was 70 ± 6,3 mmHg at diastolic left ventricular pressure of 10 mmHg. In the HTK solution group (n = 5), in all of the experiments after the start of blood flow, the transplanted heart did not begin to contract, and all 5 hearts remained in an asystole state. Therefore, after the end of the 3-hour reperfusion period, the assessment of the contractility of the left ventricle using the Langendorff apparatus was not carried out. Coronary flow rate was only 0,4 ± 0,1 ml/min, probably resulting from inadequate cardioprotection with HTK solution. Due to the lack of adequate reperfusion, the accurate assessment of the irreversible myocardial damage was impossible in the HTK solution group.Conclusions. The technique of heterotopic heart transplantation in rats is adequate and informative for the study of ischemia-reperfusion myocardial damage as well as for the study of the effectiveness of cardioplegic and cardiac preservation solutions. Cardioplegic solution based on Krebs– Henseleit buffer demonstrated greater cardioprotective effectiveness in our model compared to HTK solution.

Long term outcome after heterotopic heart transplantation

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
J Sindermann ◽  
I Alejnik ◽  
J Hoffmann ◽  
S Klotz ◽  
A Löher ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Heterotopic Heart Transplantation

scholarly journals Two hearts, one soul: heterotopic heart transplantation follow-up with cardiac computed tomography

2016 ◽  
Vol 37 (44) ◽  
pp. 3356-3356 ◽  
Author(s):  
Charles Roux ◽  
Shaida Varnous ◽  
Pascal Leprince ◽  
Philippe Cluzel
Keyword(s):  
Computed Tomography ◽  
Heart Transplantation ◽  
Cardiac Computed Tomography ◽  
Heterotopic Heart Transplantation
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