scholarly journals Physicochemical Characterization and In Vitro Dissolution Test of Quercetin-Succinic Acid Co-crystals Prepared Using Solvent Evaporation

2017 ◽  
pp. 280-284 ◽  
Author(s):  
Dwi SETYAWAN ◽  
Indah Pudji OKTAVIA ◽  
Rizka FARIZKA ◽  
Retno SARI
Keyword(s):  
Succinic Acid ◽  
Physicochemical Characterization ◽  
Solvent Evaporation ◽  
In Vitro Dissolution ◽  
Dissolution Test

scholarly journals Development and Validation of an Eco-friendly HPLC-UV-DAD Method for the Determination of Allopurinol in Pharmaceuticals with Application to In vitro Dissolution Studies

2021 ◽  
Vol 11 (5) ◽  
pp. 13089-13101
Keyword(s):  
Factorial Design ◽  
Matrix Effects ◽  
Dissolution Kinetics ◽  
In Vitro Dissolution ◽  
Dissolution Test ◽  
Dissolution Studies ◽  
Dissolution Tests ◽  
Development And Validation

In this study, a sustainable HPLC-UV-DAD method was developed and validated for the determination of allopurinol in tablets and optimization of the dissolution test using factorial design. The separation of the analyte from the sample matrix was achieved in 3.01 minutes in a C8 column (4.6 mm X 150 mm X 5 μm), using mobile phase 0.1 mol L-1 HCl (25%) + ethanol (50%) + ultrapure water (25%) by UV detection at 249 nm. The method presented satisfactory analytical parameters of validation (specificity, selectivity, linearity, stability, precision, accuracy, and robustness), showing no matrix effects. The dissolution test was optimized by complete factorial design 23 and, the optimal conditions were: HCl 0.001 mol L-1, apparatus II (paddle) and 75 rpm. The analytical procedures and dissolution tests were applied to allopurinol tablets marketed in Bahia, Brazil, to evaluate the dissolution studies. The pharmaceuticals had similar dissolution profiles and first-order dissolution kinetics. This new and sustainable HPLC-UV-DAD method is friendly to the environment and can be used for the routine pharmaceutical analysis of allopurinol in fixed dosage forms.

scholarly journals Diclofenac-β-cyclodextrin binary systems: Physicochemical characterization and in vitro dissolution and diffusion studies

2005 ◽  
Vol 6 (3) ◽  
pp. E464-E472 ◽  
Author(s):  
Maria Letizia Manca ◽  
Marco Zaru ◽  
Guido Ennas ◽  
Donatella Valenti ◽  
Chiara Sinico ◽  
...  
Keyword(s):  
Binary Systems ◽  
Physicochemical Characterization ◽  
In Vitro Dissolution ◽  
Diffusion Studies ◽  
And Diffusion
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