scholarly journals Diclofenac-β-cyclodextrin binary systems: Physicochemical characterization and in vitro dissolution and diffusion studies

2005 ◽  
Vol 6 (3) ◽  
pp. E464-E472 ◽  
Author(s):  
Maria Letizia Manca ◽  
Marco Zaru ◽  
Guido Ennas ◽  
Donatella Valenti ◽  
Chiara Sinico ◽  
...  
Keyword(s):  
Binary Systems ◽  
Physicochemical Characterization ◽  
In Vitro Dissolution ◽  
Diffusion Studies ◽  
And Diffusion

Meloxicam β-Cyclodextrin Transdermal Gel: Physicochemical Characterization and In Vitro Dissolution and Diffusion Studies

2011 ◽  
Vol 8 (4) ◽  
pp. 381-391 ◽  
Author(s):  
Bazigha K. Abdul Rasool ◽  
Rebaz H. Gareeb ◽  
Sahar A. Fahmy ◽  
Alaa A. Abdul Rasool
Keyword(s):  
Physicochemical Characterization ◽  
In Vitro Dissolution ◽  
Diffusion Studies ◽  
And Diffusion

scholarly journals Enhanced Dissolution of Sildenafil Citrate Using Solid Dispersion with Hydrophilic Polymers: Physicochemical Characterization and In Vivo Sexual Behavior Studies in Male Rats

Polymers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 3512
Author(s):  
Mohammed F. Aldawsari ◽  
Md. Khalid Anwer ◽  
Mohammed Muqtader Ahmed ◽  
Farhat Fatima ◽  
Gamal A. Soliman ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Hydrophilic Polymers ◽  
Sildenafil Citrate ◽  
Male Rats ◽  
In Vitro Dissolution ◽  
Scanning Calorimetry ◽  
Onset Of Action

Sildenafil citrate (SLC) is a frequently used medication (Viagra®) for the treatment of erectile dysfunction (ED). Due to its poor solubility, SLC suffers from a delayed onset of action and poor bioavailability. Hence, the aim of the proposed work was to prepare and evaluate solid dispersions (SDs) with hydrophilic polymers (Kolliphor® P188, Kollidon® 30, and Kollidon®-VA64), in order to enhance the dissolution and efficacy of SLC. The SLC-SDs were prepared using a solvent evaporation method (at the ratio drug/polymer, 1:1, w/w) and characterized by Differential Scanning Calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscope (SEM), drug content, yield, and in vitro release studies. Based on this evaluation, SDs (SLC-KVA64) were optimized, with a maximum release of drug (99.74%) after 2 h for all the developed formulas. The SDs (SLC-KVA64) were further tested for sexual behavior activity in male rats, and significant enhancements in copulatory efficiency (81.6%) and inter-copulatory efficiency (44.9%) were noted in comparison to the pure SLC drug, when exposed to the optimized SLC-KVA64 formulae. Therefore, SD using Kollidon®-VA64 could be regarded as a potential strategy for improving the solubility, in vitro dissolution, and therapeutic efficacy of SLC.

scholarly journals Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol

2013 ◽  
Vol 21 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Pankajkumar S. Yadav ◽  
Vikas Kumar ◽  
Udaya Pratap Singh ◽  
Hans Raj Bhat ◽  
B. Mazumder
Keyword(s):  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
In Vitro Dissolution ◽  
Dissolution Studies ◽  
Pvp K30

scholarly journals Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes

2007 ◽  
Vol 57 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Vivek Sinha ◽  
R. Anitha ◽  
Soma Ghosh ◽  
Rachana Kumria ◽  
Jayant Bhinge ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Physicochemical Characterization ◽  
Aqueous Solubility ◽  
In Vitro Dissolution ◽  
Cyclodextrin Inclusion Complexes ◽  
Cyclodextrin Inclusion ◽  
Dissolution Behaviour ◽  
Poorly Soluble

Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes In this study, attempts were made to investigate the effects of β-cyclodextrin (β-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.

scholarly journals Preparation, Physicochemical Characterization and In-Vitro Dissolution Studies of Ketoprofen Solid Dispersion with PEG 6000 and HPMC 6 cps

2020 ◽  
Vol 23 (1) ◽  
pp. 44-53
Author(s):  
Sharmin Akhter ◽  
AKM Saif Uddin ◽  
Aninda Kumar Nath ◽  
Md Salahuddin ◽  
Mohammad Fahim Kadir ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Absorption ◽  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Entrapment Efficiency ◽  
In Vitro Dissolution ◽  
Dissolution Behavior ◽  
Fixed Amount ◽  
Peg 6000

Ketoprofen [2-(3-benzoylphenyl)-propionic acid], a non-steroidal anti-inflammatory drug exhibits poor dissolution pattern. Solid dispersion (SD) techniques were used because it is particularly promising to improve the oral absorption and bioavailability of BCS Class II drugs. This investigation entails solid dispersion of ketoprofen which was formulated and characterized for better release profile and immediate action of the drug. Melting method was applied to prepare solid dispersion by using two immediate release (IR) polymer PEG 6000 and HPMC 6 cps at different weight ratios. In the formulation, a fixed amount of lactose was used as adsorbent. The solid dispersions were investigated for drug entrapment efficiency and dissolution behavior. In vitro dissolution study was performed in phosphate buffer (pH 7.4) medium for one hour. Percent cumulative drug release from solid dispersion was found to be minimum 92.19% and maximum 98.95% within one hour, which showed a better dissolution compared to the active drugs. Evaluation of the properties of the solid dispersion was also performed by using Scanning Electron Microscopy (SEM) study and Differential Thermal Analysis (DTA). SEM results indicated that ketoprofen crystallinity in SDs was significantly reduced, and that the majority of ketoprofen was in amorphous form. No interaction was found between drug and polymers from DTA and Fourier-transform infrared (FTIR) spectroscopy analysis. So, solid dispersion technique may be an effective technique to enhance dissolution rate of ketoprofen. Bangladesh Pharmaceutical Journal 23(1): 44-53, 2020

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