An Experimental Model for Closed Head Impact Injury

1976 ◽  
Author(s):  
Alan M. Nahum ◽  
Randall W. Smith
Keyword(s):  
Experimental Model ◽  
Head Impact ◽  
Closed Head ◽  
Impact Injury

P2-055: Early Chronic Traumatic Encephalopathy in Young Athletes After Concussive Closed-Head Impact Injury and Mouse Model of Impact Concussion

2016 ◽  
Vol 12 ◽  
pp. P628-P629
Author(s):  
Lee E. Goldstein ◽  
Chad A. Tagge ◽  
Andrew M. Fisher ◽  
Olga Minaeva ◽  
Amanda Gaudreau ◽  
...  
Keyword(s):  
Mouse Model ◽  
Chronic Traumatic Encephalopathy ◽  
Head Impact ◽  
Young Athletes ◽  
Closed Head ◽  
Impact Injury

A coupled physical-computational methodology for the investigation of short fall related infant head impact injury

2019 ◽  
Vol 300 ◽  
pp. 170-186 ◽  
Author(s):  
Ghaidaa A. Khalid ◽  
Raj K. Prabhu ◽  
Owen Arthurs ◽  
Michael D. Jones
Keyword(s):  
Head Impact ◽  
Computational Methodology ◽  
Impact Injury

Internal Jugular Vein Compression Collar Mitigates Histopathological Alterations after Closed Head Rotational Head Impact in Swine: A Pilot Study

Neuroscience ◽  
2020 ◽  
Vol 437 ◽  
pp. 132-144
Author(s):  
Rebekah Mannix ◽  
Nicholas J. Morriss ◽  
Grace M. Conley ◽  
William P. Meehan ◽  
Arthur Nedder ◽  
...  
Keyword(s):  
Pilot Study ◽  
Internal Jugular Vein ◽  
Jugular Vein ◽  
Head Impact ◽  
Histopathological Alterations ◽  
Closed Head

scholarly journals Simulation of the development of frontal head impact injury

2000 ◽  
Vol 26 (3) ◽  
pp. 229-235 ◽  
Author(s):  
M. D. Gilchrist ◽  
D. O'Donoghue
Keyword(s):  
Head Impact ◽  
Impact Injury

Temporal changes in intracranial pressure in a modified experimental model of closed head injury

1998 ◽  
Vol 89 (5) ◽  
pp. 796-806 ◽  
Author(s):  
Koen Engelborghs ◽  
Jan Verlooy ◽  
Jos Van Reempts ◽  
Bruno Van Deuren ◽  
Mies Van de Ven ◽  
...  
Keyword(s):  
Head Injury ◽  
Intracranial Pressure ◽  
Experimental Model ◽  
Closed Head Injury ◽  
Content Type ◽  
Closed Head ◽  
Impact Acceleration ◽  
The Moment ◽  
The Impact ◽  
Fine Print

Object. The authors describe an experimental model of closed head injury in rodents that was modified from one developed by Marmarou and colleagues. This modification allows dual control of the dynamic process of impact compared with impulse loading that occurs at the moment of primary brain injury. The principal element in this weight-drop model is an adjustable table that supports the rat at the moment of impact from weights positioned at different heights (accelerations). The aim was to obtain reproducible pathological intracranial pressure (ICPs) while maximally reducing the incidence of mortality and skull fractures. Methods. Intracranial pressure was investigated in different experimental settings, including two different rat strains and various impact-acceleration conditions and posttrauma survival times. Identical impact-acceleration injuries produced a considerably higher mortality rate in Wistar rats than in Sprague—Dawley rats (50% and 0%, respectively). Gradually increasing severity of impact-acceleration conditions resulted in findings of a significant correlation between the degree of traumatic challenge and increased ICP at 4 hours (p < 0.001, R2 = 0.73). When the impact-acceleration ratio was changed to result in a more severe head injury, the ICP at 4, 24, and 72 hours was significantly elevated in comparison with that seen in sham-injured rats (4 hours: 19.7 ± 2.8 mm Hg, p = 0.004; 24 hours: 21.8 ± 1.1 mm Hg, p = 0.002; 72 hours: 11.9 ± 2.5 mm Hg, p = 0.009). Comparison of the rise in ICP between moderate and severe impact-acceleration injury at 4 and 24 hours revealed a significantly higher value after severe injury (4 hours: p = 0.008; 24 hours: p = 0.004). Continuous recordings showed that ICP mounted very rapidly to peak values, which declined gradually toward a pathological level dependent on the severity of the primary insult. Histological examination after severe trauma revealed evidence of irreversible neuronal necrosis, diffuse axonal injury, petechial bleeding, glial swelling, and perivascular edema. Conclusions. This modified closed head injury model mimics several clinical features of traumatic injury and produces reliable, predictable, and reproducible ICP elevations with concomitant morphological alterations.

Computational Studies of Strain Exposures in Neonate and Mature Rat Brains during Closed Head Impact

2006 ◽  
Vol 23 (10) ◽  
pp. 1570-1580 ◽  
Author(s):  
Anna Levchakov ◽  
Eran Linder-Ganz ◽  
Ramesh Raghupathi ◽  
Susan S. Margulies ◽  
Amit Gefen
Keyword(s):  
Head Impact ◽  
Computational Studies ◽  
Closed Head

Optimal Protection in Direct Closed Head Impact

1976 ◽  
Vol BME-23 (1) ◽  
pp. 29-35
Author(s):  
Y. King Liu ◽  
Enayatollah P. Nikravesh ◽  
Charles H. Beck
Keyword(s):  
Head Impact ◽  
Closed Head ◽  
Optimal Protection
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