scholarly journals Repetitive Closed-Head Impact Model of Engineered Rotational Acceleration Induces Long-Term Cognitive Impairments with Persistent Astrogliosis and Microgliosis in Mice

2017 ◽  
Vol 34 (14) ◽  
pp. 2291-2302 ◽  
Author(s):  
Huazhen Chen ◽  
Abhishek Desai ◽  
Hee-Yong Kim
Keyword(s):  
Cognitive Impairments ◽  
Head Impact ◽  
Impact Model ◽  
Rotational Acceleration ◽  
Closed Head

scholarly journals Magnitude of Head Impact Exposures in Individual Collegiate Football Players

2012 ◽  
Vol 28 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Joseph J. Crisco ◽  
Bethany J. Wilcox ◽  
Jason T. Machan ◽  
Thomas W. McAllister ◽  
Ann-Christine Duhaime ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Linear Acceleration ◽  
Head Impact ◽  
Football Players ◽  
Rotational Acceleration ◽  
Head Impacts ◽  
Factors Associated ◽  
Impact Location ◽  
Collegiate Football

The purpose of this study was to quantify the severity of head impacts sustained by individual collegiate football players and to investigate differences between impacts sustained during practice and game sessions, as well as by player position and impact location. Head impacts (N = 184,358) were analyzed for 254 collegiate players at three collegiate institutions. In practice, the 50th and 95th percentile values for individual players were 20.0 g and 49.5 g for peak linear acceleration, 1187 rad/s2 and 3147 rad/s2 for peak rotational acceleration, and 13.4 and 29.9 for HITsp, respectively. Only the 95th percentile HITsp increased significantly in games compared with practices (8.4%, p = .0002). Player position and impact location were the largest factors associated with differences in head impacts. Running backs consistently sustained the greatest impact magnitudes. Peak linear accelerations were greatest for impacts to the top of the helmet, whereas rotational accelerations were greatest for impacts to the front and back. The findings of this study provide essential data for future investigations that aim to establish the correlations between head impact exposure, acute brain injury, and long-term cognitive deficits.

scholarly journals COMPARISON OF HEAD IMPACT BIOMECHANICS BETWEEN TACKLE AND FLAG YOUTH FOOTBALL

2019 ◽  
Vol 7 (3_suppl) ◽  
pp. 2325967119S0000
Author(s):  
Landon B. Lempke ◽  
A. Faith Bartello ◽  
Melissa N. Anderson ◽  
Rachel S. Johnson ◽  
Julianne D. Schmidt ◽  
...  
Keyword(s):  
Linear Acceleration ◽  
Head Impact ◽  
Football Players ◽  
Rotational Acceleration ◽  
Head Impacts ◽  
Head Impact Biomechanics ◽  
Impact Rate ◽  
High Magnitude ◽  
Impact Biomechanics

Background: There is growing fear among healthcare professionals and parents regarding youth tackle football, likely due to highly publicized concerns about potential long-term physical and cognitive health of professional football players. Parents and advocacy groups are pushing for state legislation to ban youth tackle football in favor of flag football to avoid repetitive head impacts that are potentially associated with late-life cognitive deficits. Although the head impact burden experienced during flag football is likely lower than tackle, no research has compared head impact exposure between youth tackle and flag football. Therefore, our purpose was to examine head impact exposure and magnitudes between youth tackle and flag football players. Methods: Twenty-seven tackle (age=11.0±1.5y, height=145.8±11.9 cm, mass=45.0±14.9 kg) and 29 flag football players (age=8.6±1.1y, height=133.9±8.4 cm, mass=33.9±9.5 kg) were enrolled in this prospective cohort study. Participants were fitted with head impact sensors (Triax Sim-G) worn throughout the entire 2017 season that recorded impact frequency and magnitude (linear [g] and rotational acceleration [rad/s2]). Athlete exposure was defined as one player participating in one session. Impact rates (IR) were calculated as impacts per one athlete exposure. Game, practice, and combined IR were compared between groups using impact rate ratios (IRR). IRR with 95% confidence intervals (CI) not containing 1.0 were considered statistically significant. Acceleration values were binned into low- and high-magnitude categories (linear split at 40 g, rotational split at 4,600rad/s2). Magnitude category frequencies were compared between groups using Chi-square test of association (p<0.05), and 90th percentile acceleration values are presented. Results: One-thousand nine-hundred and eight tackle (735 game, 1173 practice; 70.66 impacts/player) and 169 flag (101 game, 68 practice; 5.83 impacts/player) football head impacts were recorded. Tackle players experienced a higher impact rate during games versus practices (IRR=1.41; 95%CI:1.29 -1.55) while flag players experienced a lower impact rate (IRR=0.60; 95%CI:0.44-0.81). Practice and game head impacts combined resulted in tackle players (IR=3.06) accruing 4.61 times the impact rate (95%CI:3.94-5.40) of flag players (IR=0.66). Tackle players sustained a significantly greater head impact rate than flag players during games (tackle IR=3.83, flag IR=0.55; IRR=6.90; 95%CI:5.60-8.49) and practices (tackle IR=2.72, flag IR=0.93; IRR=2.91; 95%CI:2.28-3.72). Tackle 90th percentile linear acceleration was 53.32 g (median=32.50 g) and flag was 53.32 g (median=32.65 g). Tackle 90th percentile rotational acceleration was 7,000 rad/s2 (median=3,200rad/s2) while flag was 8,300 rad/s2 (median=4,100rad/s2). Tackle experienced a significantly higher frequency of low-magnitude rotational acceleration impacts (71.6% vs. 57.4%) and lower frequency of high-magnitude impacts than flag (28.4% vs 42.6%;?2=15.15, p<0.001). There were no significant associations for linear acceleration (p=0.75). Conclusions/Significance: Our results indicate youth flag football head impact rates are 82%-88% lower compared to tackle. Contrary to general belief, youth flag football players experienced numerous head impacts with a greater tendency for high-magnitude rotational acceleration head impacts. Although fewer head impacts occur during youth flag football, parents and coaches should be aware that head impacts do occur during practices and games. Whether high-magnitude or high-frequency head impacts influence long-term health remains unknown. Our findings provide novel evidence into the head impact exposure occurring during youth tackle and flag football. Longitudinal studies examining head impact biomechanics and advanced neuroimaging in youth tackle and flag football players nationwide is warranted to ensure long term cognitive health.

Concussion, neuroethics, and sport: Policies of the past do not suffice for the future

2017 ◽  
Author(s):  
Brad Partridge ◽  
Wayne Hall
Keyword(s):  
Mental Health ◽  
Head Trauma ◽  
Mental Health Problems ◽  
Ethical Issues ◽  
Cognitive Impairments ◽  
Concussion Management ◽  
Design And Implementation ◽  
The Past ◽  
Management Policies

Concussion management policies have become a major priority worldwide for sports that involve frequent collisions between participants because repeated head trauma has been associated with long-term cognitive impairments, mental health problems, and some forms of neurological degeneration. A number of concussion management policies have been developed by professional bodies and subsequently adopted by various sporting leagues. These have offered little guidance on how to navigate ethical issues in identifying and managing concussion. This chapter discusses ethical issues that arise in the diagnosis of concussion, debates about the longer-term consequences of repeated concussion injuries, and the design and implementation of policies that aim to prevent and manage concussion injuries in sporting matches.

Head Impact Biomechanics in Youth Flag Football: A Prospective Cohort Study

2021 ◽  
pp. 036354652110266
Author(s):  
Landon B. Lempke ◽  
Rachel S. Johnson ◽  
Rachel K. Le ◽  
Melissa N. Anderson ◽  
Julianne D. Schmidt ◽  
...  
Keyword(s):  
Mixed Model ◽  
Linear Acceleration ◽  
Cross Sectional Study ◽  
Head Impact ◽  
Rotational Acceleration ◽  
Event Type ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Head Impact Biomechanics ◽  
Impact Biomechanics

Background: Youth flag football participation has rapidly grown and is a potentially safer alternative to tackle football. However, limited research has quantitatively assessed youth flag football head impact biomechanics. Purpose: To describe head impact biomechanics outcomes in youth flag football and explore factors associated with head impact magnitudes. Study Design: Cross-sectional study; Level of evidence, 3. Methods: We monitored 52 player-seasons among 48 male flag football players (mean ± SD; age, 9.4 ± 1.1 years; height, 138.6 ± 9.5 cm; mass, 34.7 ± 9.2 kg) across 3 seasons using head impact sensors during practices and games. Sensors recorded head impact frequencies, peak linear ( g) and rotational (rad/s2) acceleration, and estimated impact location. Impact rates (IRs) were calculated as 1 impact per 10 player-exposures; IR ratios (IRRs) were used to compare season, event type, and age group IRs; and 95% CIs were calculated for IRs and IRRs. Weekly and seasonal cumulative head impact frequencies and magnitudes were calculated. Mixed-model regression models examined the association between player characteristics, event type, and seasons and peak linear and rotational accelerations. Results: A total of 429 head impacts from 604 exposures occurred across the study period (IR, 7.10; 95% CI, 4.81-10.50). Weekly and seasonal cumulative median head impact frequencies were 1.00 (range, 0-2.63) and 7.50 (range, 0-21.00), respectively. The most frequent estimated head impact locations were the skull base (n = 96; 22.4%), top of the head (n = 74; 17.2%), and back of the head (n = 66; 15.4%). The combined event type IRs differed among the 3 seasons (IRR range, 1.45-2.68). Games produced greater IRs (IRR, 1.24; 95% CI, 1.01-1.53) and peak linear acceleration (mean difference, 5.69 g; P = .008) than did practices. Older players demonstrated greater combined event–type IRs (IRR, 1.46; 95% CI, 1.12-1.90) and increased head impact magnitudes than did younger players, with every 1-year age increase associated with a 3.78 g and 602.81-rad/s2 increase in peak linear and rotational acceleration magnitude, respectively ( P≤ .005). Conclusion: Head IRs and magnitudes varied across seasons, thus highlighting multiple season and cohort data are valuable when providing estimates. Head IRs were relatively low across seasons, while linear and rotational acceleration magnitudes were relatively high.

scholarly journals Football concussion case series using biomechanical and video analysis

Neurology ◽  
2018 ◽  
Vol 91 (23 Supplement 1) ◽  
pp. S2.2-S2
Author(s):  
Mirellie Kelley ◽  
Jillian Urban ◽  
Derek Jones ◽  
Alexander Powers ◽  
Christopher T. Whitlow ◽  
...  
Keyword(s):  
Video Analysis ◽  
Case Series ◽  
Linear Acceleration ◽  
The United States ◽  
Head Impact ◽  
Rotational Acceleration ◽  
Impact Location ◽  
Injury Mechanisms ◽  
The Mean ◽  
Impact Data

Approximately 1.1–1.9 million sport-related concussions among athletes ≤18 years of age occur annually in the United States, but there is limited understanding of the biomechanics and injury mechanisms associated with concussions among lower level football athletes. Therefore, the objective of this study was to combine biomechanical head impact data with video analysis to characterize youth and HS football concussion injury mechanisms. Head impact data were collected from athletes participating on 22 youth and 6 HS football teams between 2012 and 2017. Video was recorded, and head impact data were collected during all practices and games by instrumenting players with the Head Impact Telemetry (HIT) System. For each clinically diagnosed concussion, a video abstraction form was completed, which included questions concerning the context in which the injury occurred. Linear acceleration, rotational acceleration, and impact location were used to characterize the concussive event and each injured athlete's head impact exposure on the day of the concussion. A total of 9 (5 HS and 4 youth) concussions with biomechanics and video of the event were included in this study. The mean [range] linear and rotational acceleration of the concussive impacts were 62.9 [29.3–118.4] g and 3,056.7 [1,046.8–6,954.6] rad/s2, respectively. Concussive impacts were the highest magnitude impacts for 6 players and in the top quartile of impacts for 3 players on the day of injury. Concussions occurred in both practices (N = 4) and games (N = 5). The most common injury contact surface was helmet-to-helmet (N = 5), followed by helmet-to-ground (N = 3) and helmet-to-body (N = 1). All injuries occurred during player-to-player contact scenarios, including tackling (N = 4), blocking (N = 4), and collision with other players (N = 1). The biomechanics and injury mechanisms of concussions varied among athletes in our study; however, concussive impacts were among the highest severity for each player and all concussions occurred as a result of player-to-player contact.

scholarly journals Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

2018 ◽  
Vol 10 (471) ◽  
pp. eaan0237 ◽  
Author(s):  
Diego F. Niño ◽  
Qinjie Zhou ◽  
Yukihiro Yamaguchi ◽  
Laura Y. Martin ◽  
Sanxia Wang ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Microglial Activation ◽  
Gastrointestinal Disease ◽  
Cognitive Impairments ◽  
High Mobility ◽  
Neurological Dysfunction ◽  
Mucosal Inflammation ◽  
Signaling Axis ◽  
The Brain

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant. One of the most important long-term complications observed in children who survive NEC early in life is the development of profound neurological impairments. However, the pathways leading to NEC-associated neurological impairments remain unknown, thus limiting the development of prevention strategies. We have recently shown that NEC development is dependent on the expression of the lipopolysaccharide receptor Toll-like receptor 4 (TLR4) on the intestinal epithelium, whose activation by bacteria in the newborn gut leads to mucosal inflammation. Here, we hypothesized that damage-induced production of TLR4 endogenous ligands in the intestine might lead to activation of microglial cells in the brain and promote cognitive impairments. We identified a gut-brain signaling axis in an NEC mouse model in which activation of intestinal TLR4 signaling led to release of high-mobility group box 1 in the intestine that, in turn, promoted microglial activation in the brain and neurological dysfunction. We further demonstrated that an orally administered dendrimer-based nanotherapeutic approach to targeting activated microglia could prevent NEC-associated neurological dysfunction in neonatal mice. These findings shed light on the molecular pathways leading to the development of NEC-associated brain injury, provide a rationale for early removal of diseased intestine in NEC, and indicate the potential of targeted therapies that protect the developing brain in the treatment of NEC in early childhood.

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