scholarly journals Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats

2020 ◽  
Vol 35 (4) ◽  
pp. 286-295
Author(s):  
Yoonsoo Park ◽  
Ji Hyeon Ahn ◽  
Tae-Kyeong Lee ◽  
Bora Kim ◽  
Hyun-Jin Tae ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
And Oxidative Stress ◽  
Asphyxial Cardiac Arrest

scholarly journals Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats

2006 ◽  
Vol 1111 (1) ◽  
pp. 166-175 ◽  
Author(s):  
Xiaofeng Jia ◽  
Matthew A. Koenig ◽  
Hyun-Chool Shin ◽  
Gehua Zhen ◽  
Soichiro Yamashita ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Quantitative Eeg ◽  
Neurological Recovery ◽  
Asphyxial Cardiac Arrest

Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress

2019 ◽  
Vol 320 ◽  
pp. 112983 ◽  
Author(s):  
Jeong Hwi Cho ◽  
Hyun-Jin Tae ◽  
In-Shik Kim ◽  
Minah Song ◽  
Hyunjung Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Cardiac Arrest ◽  
Purkinje Cell ◽  
Cerebellar Purkinje Cell ◽  
Purkinje Cell Death ◽  
Asphyxial Cardiac Arrest

scholarly journals Therapeutic hypothermia preserves the brain by reducing nitric oxide synthase after asphyxial cardiac arrest in rats

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P375 ◽  
Author(s):  
D Ndjekembo Shango ◽  
S Hachimi-Idrissi ◽  
G Ebinger ◽  
Y Michotte ◽  
L Huyghens
Keyword(s):  
Nitric Oxide ◽  
Cardiac Arrest ◽  
Nitric Oxide Synthase ◽  
Therapeutic Hypothermia ◽  
Oxide Synthase ◽  
The Brain ◽  
Asphyxial Cardiac Arrest

Protective effects of therapeutic hypothermia on renal injury in an asphyxial cardiac arrest rat model

2020 ◽  
Vol 94 ◽  
pp. 102761
Author(s):  
Anowarul Islam ◽  
So Eun Kim ◽  
Jae Chol Yoon ◽  
Ali Jawad ◽  
Weishun Tian ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Rat Model ◽  
Renal Injury ◽  
Protective Effects ◽  
Asphyxial Cardiac Arrest

scholarly journals Status of Systemic Oxidative Stress during Therapeutic Hypothermia in Patients with Post-Cardiac Arrest Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Kenji Dohi ◽  
Kazuyuki Miyamoto ◽  
Kenichiro Fukuda ◽  
Shunsuke Nakamura ◽  
Munetaka Hayashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Brain Temperature ◽  
Antioxidant Potential ◽  
Reactive Oxygen Metabolites ◽  
Systemic Oxidative Stress ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant ◽  
Post Cardiac Arrest Syndrome

Therapeutic hypothermia (TH) is thought to be due to the downregulation of free radical production, although the details of this process remain unclear. Here, we investigate changes in oxidative stress and endogenous biological antioxidant potential during TH in patients with post-cardiac arrest syndrome (PCAS). Nineteen PCAS patients were enrolled in the study. Brain temperature was decreased to the target temperature of 33°C, and it was maintained for 24 h. Patients were rewarmed slowly (0.1°C/h, <1°C/day). The generation of reactive oxygen metabolites (ROMs) was evaluated in plasma samples by d-ROM test. Plasma antioxidant capacity was measured by the biological antioxidant potential (BAP) test. Levels of d-ROMs and BAP levels during the hypothermic stage (33°C) were suppressed significantly compared with pre-TH induction levels (P<0.05), while both d-ROM and BAP levels increased with rewarming (33–36°C) and were correlated with brain temperature. Clinical monitoring of oxidative stress and antioxidant potential is useful for evaluating the redox state of patients undergoing TH after PCAS. Additional therapy to support the antioxidant potential in the rewarming stage following TH may reduce some of the observed side effects associated with the use of TH.

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