scholarly journals Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats

2006 ◽  
Vol 1111 (1) ◽  
pp. 166-175 ◽  
Author(s):  
Xiaofeng Jia ◽  
Matthew A. Koenig ◽  
Hyun-Chool Shin ◽  
Gehua Zhen ◽  
Soichiro Yamashita ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Quantitative Eeg ◽  
Neurological Recovery ◽  
Asphyxial Cardiac Arrest

scholarly journals Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats

2020 ◽  
Vol 35 (4) ◽  
pp. 286-295
Author(s):  
Yoonsoo Park ◽  
Ji Hyeon Ahn ◽  
Tae-Kyeong Lee ◽  
Bora Kim ◽  
Hyun-Jin Tae ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
And Oxidative Stress ◽  
Asphyxial Cardiac Arrest

scholarly journals Our experiences with therapeutic hypothermia

2007 ◽  
Vol 60 (9-10) ◽  
pp. 431-435 ◽  
Author(s):  
Milovan Petrovic ◽  
Ilija Srdanovic ◽  
Gordana Panic ◽  
Tibor Canji ◽  
Tihomir Miljevic
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Neurological Outcome ◽  
Mild Hypothermia ◽  
Acute Myocarditis ◽  
Neuroprotective Effect ◽  
Sudden Cardiac Arrest ◽  
Neurological Recovery ◽  
Global Cerebral Ischemia ◽  
Resuscitation Guidelines

Introduction. The single most important clinically relevant cause of global cerebral ischemia is cardiac arrest. The estimated rate of sudden cardiac arrest is between 40 and 130 cases per 100.000 people per year. Almost 80% of patients initially resuscitated from cardiac arrest remain comatose for more than one hour. One year after cardiac arrest only 10-30% of these patients survive with good neurological outcome. The ability to survive anoxic no-flow states is dramatically increased with protective and preservative hypothermia. The results of clinical studies show a marked neuroprotective effect of mild hypothermia in resuscitation. Material and Methods. In our clinic, 12 patients were treated with therapeutic hypothermia. A combination of intravascular and external method of cooling was used according to the ILCOR (International Liaison Committee on Resuscitation) guidelines. The target temperature was 33oC, while the duration of cooling was 24 hours. After that, passive rewarming was allowed. All patients also received other necessary therapy. Results. Six patients (50%) had a complete neurological recovery. Two patients (16.6%) had partial neurological recovery. Four patients (33.3%) remained comatose. Five patients (41.66%) survived, while 7 (58.33%) patients died. The main cause of cardiac arrest was acute myocardial infarction (91.6%). One patient had acute myocarditis. Conclusion. Mild resuscitative hypothermia after cardiac arrest improves neurological outcome and reduces mortality in comatose survivors. .

Targeted temperature management: beneficial or not?

2020 ◽  
Vol 12 (6) ◽  
pp. 235-241 ◽  
Author(s):  
Kelley Ricketts ◽  
Bridie Jones
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Survival Rates ◽  
Treatment Strategies ◽  
Targeted Temperature Management ◽  
Prehospital Setting ◽  
Neurological Recovery ◽  
Temperature Management ◽  
Potential Treatment ◽  
Potential Benefits

Targeted temperature management (TTM), formerly known as therapeutic hypothermia, has been shown to improve survival and neurological recovery in patients following cardiac arrest. Following successes with its in-hospital implementation, many guidelines now advocate its use in the prehospital domain for all out-of-hospital cardiac arrests (OHCAs). It has been suggested that patients presenting with shockable rhythms who receive early initiation of TTM have better survival rates. TTM can be initiated in the prehospital setting with minimal equipment. This article discusses and explores the potential benefits and pitfalls of targeted temperature management when initiated in the prehospital environment. Particular focus is given to potential treatment strategies that can be used by paramedics to adequately manage OHCA. It is proposed that prehospital TTM is advantageous to all patients in cardiac arrest and can be efficacious in a variety of prehospital environments, with its implementation requiring only minimal equipment.

scholarly journals Therapeutic hypothermia preserves the brain by reducing nitric oxide synthase after asphyxial cardiac arrest in rats

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P375 ◽  
Author(s):  
D Ndjekembo Shango ◽  
S Hachimi-Idrissi ◽  
G Ebinger ◽  
Y Michotte ◽  
L Huyghens
Keyword(s):  
Nitric Oxide ◽  
Cardiac Arrest ◽  
Nitric Oxide Synthase ◽  
Therapeutic Hypothermia ◽  
Oxide Synthase ◽  
The Brain ◽  
Asphyxial Cardiac Arrest

Protective effects of therapeutic hypothermia on renal injury in an asphyxial cardiac arrest rat model

2020 ◽  
Vol 94 ◽  
pp. 102761
Author(s):  
Anowarul Islam ◽  
So Eun Kim ◽  
Jae Chol Yoon ◽  
Ali Jawad ◽  
Weishun Tian ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Therapeutic Hypothermia ◽  
Rat Model ◽  
Renal Injury ◽  
Protective Effects ◽  
Asphyxial Cardiac Arrest
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