scholarly journals Application of Diffusion Tensor Imaging (DTI) Tractography as a Targeting Modality for Deep Brain Stimulation (DBS) of the Subthalamic Nucleus (STN)

2015 ◽  
Vol 74 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Mitsuru Watanabe ◽  
Koichiro Sumi ◽  
Toshiki Obuchi ◽  
Katsunori Shijo ◽  
Toshikazu Kano ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Diffusion Tensor ◽  
Dti Tractography ◽  
Diffusion Tensor Imaging Dti ◽  
Deep Brain

MEDIAL FOREBRAIN BUNDLE STIMULATION AS A PATHOPHYSIOLOGICAL MECHANISM FOR HYPOMANIA IN SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION FOR PARKINSON'S DISEASE

Neurosurgery ◽  
2009 ◽  
Vol 64 (6) ◽  
pp. 1106-1115 ◽  
Author(s):  
Volker A. Coenen ◽  
Christopher R. Honey ◽  
Trevor Hurwitz ◽  
Ahmed A. Rahman ◽  
Jacqueline McMaster ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Diffusion Tensor Imaging ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Medial Forebrain Bundle ◽  
Diffusion Tensor ◽  
Stn Dbs ◽  
Deep Brain

Abstract OBJECTIVE Hypomania accounts for approximately 4% to 13% of psychotropic adverse events during subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson's disease. Diffusion of current into the inferior and medial “limbic” STN is often reported to be the cause. We suggest a different explanation, in which the coactivation of the medial forebrain bundle (MFB), outside the STN, leads to hypomania during STN DBS. METHODS Six patients with advanced Parkinson's disease (age, 54 ± 11 years) underwent bilateral STN DBS surgery. Preoperative diffusion tensor imaging scans for fiber tracking of the MFB were conducted on a 3T magnetic resonance imaging scanner. After implantation, the electrode positions were determined with computed tomography and integrated in a diffusion tensor imaging software environment. RESULTS The medial STN was shown to send tributaries to the MFB using it as a pathway to connect to the reward circuitry. One patient, who had a transient, stimulation-induced acute hypomanic episode, showed a direct contact between 1 active electrode contact and these putative limbic STN tributaries to the MFB unilaterally on the left. In 5 asymptomatic patients, the active contacts were between 2.9 and 7.5 mm distant from the MFB or its limbic STN tributaries. CONCLUSION We hypothesize that STN DBS-induced reversible acute hypomania might be elicited by inadvertent and unilateral coactivation of putative limbic STN tributaries to the MFB. These findings may provide insight into the neural pathways of hypomania and may facilitate future investigations of the pathophysiology of mood disorders.

Post-Traumatic Tremor and Thalamic Deep Brain Stimulation: Evidence for Use of Diffusion Tensor Imaging

2016 ◽  
Vol 96 ◽  
pp. 607.e7-607.e11 ◽  
Author(s):  
Sandra G.J. Boccard ◽  
Pedro Rebelo ◽  
Binith Cheeran ◽  
Alexander Green ◽  
James J. FitzGerald ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Diffusion Tensor ◽  
Post Traumatic ◽  
Deep Brain
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